Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease

Yuneivy Cepero-Donates; Grégory Lacraz; Farnaz Ghobadi; Volatiana Rakotoarivelo; Sakina Orkhis; Marian Mayhue; Yi Guang Chen; Marek Rola-Pleszczynski; Alfredo Menendez; Subburaj Ilangumaran; Sheela Ramanathan

doi:10.1016/j.cyto.2016.01.020

Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease

Yuneivy Cepero-Donates, Grégory Lacraz, Farnaz Ghobadi, Volatiana Rakotoarivelo, Sakina Orkhis, Marian Mayhue, Yi Guang Chen, Marek Rola-Pleszczynski, Alfredo Menendez, Subburaj Ilangumaran, Sheela Ramanathan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

Interleukin-15 (IL-15) is essential for the homeostasis of lymphoid cells particularly memory CD8⁺ T cells and NK cells. These cells are abundant in the liver, and are implicated in obesity-associated pathogenic processes. Here we characterized obesity-associated metabolic and cellular changes in the liver of mice lacking IL-15 or IL-15Rα. High fat diet-induced accumulation of lipids was diminished in the livers of mice deficient for IL-15 or IL-15Rα. Expression of enzymes involved in the transport of lipids in the liver showed modest differences. More strikingly, the liver tissues of IL15-KO and IL15Rα-KO mice showed decreased expression of chemokines CCl2, CCL5 and CXCL10 and reduced infiltration of mononuclear cells. In vitro, IL-15 stimulation induced chemokine gene expression in wildtype hepatocytes, but not in IL15Rα-deficient hepatocytes. Our results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease.

Original language	English
Pages (from-to)	102-111
Number of pages	10
Journal	Cytokine
Volume	82
DOIs	https://doi.org/10.1016/j.cyto.2016.01.020
Publication status	Published - 1 Jun 2016

Keywords

Inflammation
Interleukin-15
Liver
Mice
NAFLD

Access to Document

10.1016/j.cyto.2016.01.020

Cite this

@article{7719f2696c724100bd27a1216b318293,

title = "Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease",

abstract = "Interleukin-15 (IL-15) is essential for the homeostasis of lymphoid cells particularly memory CD8+ T cells and NK cells. These cells are abundant in the liver, and are implicated in obesity-associated pathogenic processes. Here we characterized obesity-associated metabolic and cellular changes in the liver of mice lacking IL-15 or IL-15Rα. High fat diet-induced accumulation of lipids was diminished in the livers of mice deficient for IL-15 or IL-15Rα. Expression of enzymes involved in the transport of lipids in the liver showed modest differences. More strikingly, the liver tissues of IL15-KO and IL15Rα-KO mice showed decreased expression of chemokines CCl2, CCL5 and CXCL10 and reduced infiltration of mononuclear cells. In vitro, IL-15 stimulation induced chemokine gene expression in wildtype hepatocytes, but not in IL15Rα-deficient hepatocytes. Our results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease.",

keywords = "Inflammation, Interleukin-15, Liver, Mice, NAFLD",

author = "Yuneivy Cepero-Donates and Gr{\'e}gory Lacraz and Farnaz Ghobadi and Volatiana Rakotoarivelo and Sakina Orkhis and Marian Mayhue and Chen, {Yi Guang} and Marek Rola-Pleszczynski and Alfredo Menendez and Subburaj Ilangumaran and Sheela Ramanathan",

year = "2016",

month = jun,

day = "1",

doi = "10.1016/j.cyto.2016.01.020",

language = "English",

volume = "82",

pages = "102--111",

journal = "Cytokine",

issn = "1043-4666",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease

AU - Cepero-Donates, Yuneivy

AU - Lacraz, Grégory

AU - Ghobadi, Farnaz

AU - Rakotoarivelo, Volatiana

AU - Orkhis, Sakina

AU - Mayhue, Marian

AU - Chen, Yi Guang

AU - Rola-Pleszczynski, Marek

AU - Menendez, Alfredo

AU - Ilangumaran, Subburaj

AU - Ramanathan, Sheela

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Interleukin-15 (IL-15) is essential for the homeostasis of lymphoid cells particularly memory CD8+ T cells and NK cells. These cells are abundant in the liver, and are implicated in obesity-associated pathogenic processes. Here we characterized obesity-associated metabolic and cellular changes in the liver of mice lacking IL-15 or IL-15Rα. High fat diet-induced accumulation of lipids was diminished in the livers of mice deficient for IL-15 or IL-15Rα. Expression of enzymes involved in the transport of lipids in the liver showed modest differences. More strikingly, the liver tissues of IL15-KO and IL15Rα-KO mice showed decreased expression of chemokines CCl2, CCL5 and CXCL10 and reduced infiltration of mononuclear cells. In vitro, IL-15 stimulation induced chemokine gene expression in wildtype hepatocytes, but not in IL15Rα-deficient hepatocytes. Our results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease.

AB - Interleukin-15 (IL-15) is essential for the homeostasis of lymphoid cells particularly memory CD8+ T cells and NK cells. These cells are abundant in the liver, and are implicated in obesity-associated pathogenic processes. Here we characterized obesity-associated metabolic and cellular changes in the liver of mice lacking IL-15 or IL-15Rα. High fat diet-induced accumulation of lipids was diminished in the livers of mice deficient for IL-15 or IL-15Rα. Expression of enzymes involved in the transport of lipids in the liver showed modest differences. More strikingly, the liver tissues of IL15-KO and IL15Rα-KO mice showed decreased expression of chemokines CCl2, CCL5 and CXCL10 and reduced infiltration of mononuclear cells. In vitro, IL-15 stimulation induced chemokine gene expression in wildtype hepatocytes, but not in IL15Rα-deficient hepatocytes. Our results show that IL-15 is implicated in the high fat diet-induced lipid accumulation and inflammation in the liver, leading to fatty liver disease.

KW - Inflammation

KW - Interleukin-15

KW - Liver

KW - Mice

KW - NAFLD

UR - http://www.scopus.com/inward/record.url?scp=84956921610&partnerID=8YFLogxK

U2 - 10.1016/j.cyto.2016.01.020

DO - 10.1016/j.cyto.2016.01.020

M3 - Article

C2 - 26868085

AN - SCOPUS:84956921610

SN - 1043-4666

VL - 82

SP - 102

EP - 111

JO - Cytokine

JF - Cytokine

ER -

Interleukin-15-mediated inflammation promotes non-alcoholic fatty liver disease

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this