Interictal PET and Its Value in the Localization of the Seizure-Onset Zone

Nelleke Tolboom; Alfred Meurs; Donatienne Van Weehaeghe

doi:10.1007/978-3-032-04182-1_8

Interictal PET and Its Value in the Localization of the Seizure-Onset Zone

Nelleke Tolboom
, Alfred Meurs
, Donatienne Van Weehaeghe^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Abstract

PET imaging enables, among others, noninvasive visualization of glucose metabolism using [¹⁸F]FDG. In focal epilepsy patients, the whole irritative zone is hypometabolic and called the functional deficit zone (FDZ). This is in contrast with the high physiological uptake in the surrounding healthy cortex. Interictal [¹⁸F]FDG PET can help to identify the seizure-onset zone both in temporal and extratemporal epilepsy. It plays a unique and important role in the presurgical workup for patients with drug-resistant epilepsy (DRE), more specifically in MRI-negative patients, when the MRI shows multiple lesions or when the MRI is discordant with other information such as the EEG or semiology. Moreover, it can provide prognostic information as surgical outcome is related to the extent of the hypometabolic zone beyond the seizure-onset zone.

Original language	English
Title of host publication	Controversies in Epilepsy Surgery
Subtitle of host publication	Minimally Invasive Techniques and Recent Developments
Editors	Dirk Van Roost, Olaf E. M. G. Schijns
Publisher	Springer
Pages	81-87
Number of pages	7
ISBN (Electronic)	9783032041821
ISBN (Print)	9783032041814
DOIs	https://doi.org/10.1007/978-3-032-04182-1_8
Publication status	Published - 1 Apr 2026

Keywords

DPA714
FDG PET
Flumazenil
Functional deficit zone
Glucose metabolism
Hypometabolism
Seizure-onset zone detection
Surgery workup
Tracer
Translocator protein

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10.1007/978-3-032-04182-1_8

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abstract = "PET imaging enables, among others, noninvasive visualization of glucose metabolism using [18F]FDG. In focal epilepsy patients, the whole irritative zone is hypometabolic and called the functional deficit zone (FDZ). This is in contrast with the high physiological uptake in the surrounding healthy cortex. Interictal [18F]FDG PET can help to identify the seizure-onset zone both in temporal and extratemporal epilepsy. It plays a unique and important role in the presurgical workup for patients with drug-resistant epilepsy (DRE), more specifically in MRI-negative patients, when the MRI shows multiple lesions or when the MRI is discordant with other information such as the EEG or semiology. Moreover, it can provide prognostic information as surgical outcome is related to the extent of the hypometabolic zone beyond the seizure-onset zone.",

keywords = "DPA714, FDG PET, Flumazenil, Functional deficit zone, Glucose metabolism, Hypometabolism, Seizure-onset zone detection, Surgery workup, Tracer, Translocator protein",

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Interictal PET and Its Value in the Localization of the Seizure-Onset Zone. / Tolboom, Nelleke; Meurs, Alfred; Van Weehaeghe, Donatienne.
Controversies in Epilepsy Surgery: Minimally Invasive Techniques and Recent Developments. ed. / Dirk Van Roost; Olaf E. M. G. Schijns. Springer, 2026. p. 81-87.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

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T1 - Interictal PET and Its Value in the Localization of the Seizure-Onset Zone

AU - Tolboom, Nelleke

AU - Meurs, Alfred

AU - Van Weehaeghe, Donatienne

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PY - 2026/4/1

Y1 - 2026/4/1

N2 - PET imaging enables, among others, noninvasive visualization of glucose metabolism using [18F]FDG. In focal epilepsy patients, the whole irritative zone is hypometabolic and called the functional deficit zone (FDZ). This is in contrast with the high physiological uptake in the surrounding healthy cortex. Interictal [18F]FDG PET can help to identify the seizure-onset zone both in temporal and extratemporal epilepsy. It plays a unique and important role in the presurgical workup for patients with drug-resistant epilepsy (DRE), more specifically in MRI-negative patients, when the MRI shows multiple lesions or when the MRI is discordant with other information such as the EEG or semiology. Moreover, it can provide prognostic information as surgical outcome is related to the extent of the hypometabolic zone beyond the seizure-onset zone.

AB - PET imaging enables, among others, noninvasive visualization of glucose metabolism using [18F]FDG. In focal epilepsy patients, the whole irritative zone is hypometabolic and called the functional deficit zone (FDZ). This is in contrast with the high physiological uptake in the surrounding healthy cortex. Interictal [18F]FDG PET can help to identify the seizure-onset zone both in temporal and extratemporal epilepsy. It plays a unique and important role in the presurgical workup for patients with drug-resistant epilepsy (DRE), more specifically in MRI-negative patients, when the MRI shows multiple lesions or when the MRI is discordant with other information such as the EEG or semiology. Moreover, it can provide prognostic information as surgical outcome is related to the extent of the hypometabolic zone beyond the seizure-onset zone.

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KW - Glucose metabolism

KW - Hypometabolism

KW - Seizure-onset zone detection

KW - Surgery workup

KW - Tracer

KW - Translocator protein

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PB - Springer

ER -

Interictal PET and Its Value in the Localization of the Seizure-Onset Zone

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