Interaction of quantitative 18F-FDG-PET-CT imaging parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma

Charlotte S. Schouten, Sara Hakim, R. Boellaard, Elisabeth Bloemena, Patricia A. Doornaert, Birgit I. Witte, Boudewijn J M Braakhuis, Ruud H. Brakenhoff, C. René Leemans, Otto S. Hoekstra, Remco De Bree*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) have a better survival than with HPV-negative oropharyngeal SCC. An 18F-fluorodeoxyglucose positron emission tomography-CT (18F-FDG-PET-CT) may also provide prognostic information. We evaluated glycolytic characteristics in HPV-negative and HPV-positive oropharyngeal SCC. Methods Forty-four patients underwent pretreatment 18F-FDG-PET-CT. Standardized uptake values (SUVs) and metabolic active tumor volumes (MATVs) were determined for primary tumors. HPV status was determined with p16 immunostaining, followed by high-risk HPV DNA detection on the positive cases. Results Twenty-seven patients were HPV-positive (61.4%). Median MATV was 2.8 mL (range = 1.6-5.1 mL) for HPV-positive and 6.0 mL (range = 4.4-18.7 mL) for HPV-negative tumors (p 18F-FDG-PET-CT parameters are lower in HPV-positive than in HPV-negative patients. Low pretreatment SUV values in HPV-positive oropharyngeal SCC may be at least partly explained by HPV-induced tumor changes.

Original languageEnglish
Pages (from-to)529-535
Number of pages7
JournalHead and Neck
Volume38
Issue number4
DOIs
Publication statusPublished - 1 Apr 2016
Externally publishedYes

Keywords

  • F-fluorodeoxyglucose positron emission tomography-CT (F-FDG PET-CT)
  • human papillomavirus
  • metabolic active tumor volume
  • oropharyngeal squamous cell carcinoma
  • standardized uptake value
  • tumor heterogeneity

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