Abstract
Background Patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) have a better survival than with HPV-negative oropharyngeal SCC. An 18F-fluorodeoxyglucose positron emission tomography-CT (18F-FDG-PET-CT) may also provide prognostic information. We evaluated glycolytic characteristics in HPV-negative and HPV-positive oropharyngeal SCC. Methods Forty-four patients underwent pretreatment 18F-FDG-PET-CT. Standardized uptake values (SUVs) and metabolic active tumor volumes (MATVs) were determined for primary tumors. HPV status was determined with p16 immunostaining, followed by high-risk HPV DNA detection on the positive cases. Results Twenty-seven patients were HPV-positive (61.4%). Median MATV was 2.8 mL (range = 1.6-5.1 mL) for HPV-positive and 6.0 mL (range = 4.4-18.7 mL) for HPV-negative tumors (p 18F-FDG-PET-CT parameters are lower in HPV-positive than in HPV-negative patients. Low pretreatment SUV values in HPV-positive oropharyngeal SCC may be at least partly explained by HPV-induced tumor changes.
Original language | English |
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Pages (from-to) | 529-535 |
Number of pages | 7 |
Journal | Head and Neck |
Volume | 38 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2016 |
Externally published | Yes |
Keywords
- F-fluorodeoxyglucose positron emission tomography-CT (F-FDG PET-CT)
- human papillomavirus
- metabolic active tumor volume
- oropharyngeal squamous cell carcinoma
- standardized uptake value
- tumor heterogeneity