Intelligence and brain efficiency: Investigating the association between working memory performance, glutamate, and GABA

Anouk Marsman*, René C.W. Mandl, Dennis W.J. Klomp, Wiepke Cahn, René S. Kahn, Peter R. Luijten, Hilleke E. Hulshoff Pol

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Intelligence is a measure of general cognitive functioning capturing a wide variety of different cognitive functions. It has been hypothesized that the brain works to minimize the resources allocated toward higher cognitive functioning. Thus, for the intelligent brain, it may be that not simply more is better, but rather, more efficient is better. Energy metabolism supports both inhibitory and excitatory neurotransmission processes. Indeed, in glutamatergic and GABAergic neurons, the primary energetic costs are associated with neurotransmission. We tested the hypothesis that minimizing resources through the excitation-inhibition balance encompassing gamma-aminobutyric acid (GABA) and glutamate may be beneficial to general cognitive functioning using 7 T 1H-MRS in 23 healthy individuals (male/female = 16/7, 27.7 ± 5.3 years). We find that a higher working memory index is significantly correlated with a lower GABA to glutamate ratio in the frontal cortex and with a lower glutamate level in the occipital cortex. Thus, it seems that working memory performance is associated with the excitation-inhibition balance in the brain.

Original languageEnglish
Article number154
Pages (from-to)1-9
Number of pages9
JournalFrontiers in Psychiatry [E]
Volume8
DOIs
Publication statusPublished - 15 Sept 2017

Keywords

  • 7 T
  • H-MRS
  • Gamma-aminobutyric acid
  • Glutamate
  • Intelligence

Fingerprint

Dive into the research topics of 'Intelligence and brain efficiency: Investigating the association between working memory performance, glutamate, and GABA'. Together they form a unique fingerprint.

Cite this