Integron Class 1 reservoir among highly resistant gram-negative microorganisms recovered at a dutch teaching hospital

Marlies J. Mooij; Ina Willemsen; Marilie Lobbrecht; Christina Vandenbroucke-Grauls; Jan Kluytmans; Paul H.M. Savelkoul

doi:10.1086/606039

Integron Class 1 reservoir among highly resistant gram-negative microorganisms recovered at a dutch teaching hospital

Marlies J. Mooij, Ina Willemsen, Marilie Lobbrecht, Christina Vandenbroucke-Grauls, Jan Kluytmans, Paul H.M. Savelkoul

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9 Citations (Scopus)

Abstract

Integrons play an important role in the dissemination of resistance genes among bacteria. Nearly 70% of highly resistant gram-negative bacteria isolated at a tertiary care hospital harbored an integron. Epidemiologic analysis suggests that horizontal gene transfer is an important mechanism of resistance spread and has a greater contribution than cross-transmission to levels of resistance in settings where highly resistant gram-negative bacteria are endemic.

Original language	English
Pages (from-to)	1015-1018
Number of pages	4
Journal	Infection control and hospital epidemiology
Volume	30
Issue number	10
DOIs	https://doi.org/10.1086/606039
Publication status	Published - Oct 2009
Externally published	Yes

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10.1086/606039

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abstract = "Integrons play an important role in the dissemination of resistance genes among bacteria. Nearly 70% of highly resistant gram-negative bacteria isolated at a tertiary care hospital harbored an integron. Epidemiologic analysis suggests that horizontal gene transfer is an important mechanism of resistance spread and has a greater contribution than cross-transmission to levels of resistance in settings where highly resistant gram-negative bacteria are endemic.",

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AU - Mooij, Marlies J.

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AU - Lobbrecht, Marilie

AU - Vandenbroucke-Grauls, Christina

AU - Kluytmans, Jan

AU - Savelkoul, Paul H.M.

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AB - Integrons play an important role in the dissemination of resistance genes among bacteria. Nearly 70% of highly resistant gram-negative bacteria isolated at a tertiary care hospital harbored an integron. Epidemiologic analysis suggests that horizontal gene transfer is an important mechanism of resistance spread and has a greater contribution than cross-transmission to levels of resistance in settings where highly resistant gram-negative bacteria are endemic.

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Integron Class 1 reservoir among highly resistant gram-negative microorganisms recovered at a dutch teaching hospital

Abstract

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