Integrin modulating factor-1: A lipid that alters the function of leukocyte integrins

Anne Hermanowski-Vosatka*, Jos A.G. Van Strijp, William J. Swiggard, Samuel D. Wright

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

126 Citations (Scopus)


The avidity of integrin CR3 (also known as αMβ2, Mac-1, Mo-1, and CD11b CD18) may be reversibly altered without changes in the number of cell surface receptors. Here we describe a molecule termed integrin modulating factor (IMF-1), which controls CR3 avidity. Addition of IMF-1 to polymorphonuclear leukocytes (PMNs) or to purified CR3 causes enhanced binding of ligand. IMF-1 is not present in resting PMNs, but stimulation of cells results in a transient rise in IMF-1 content that parallels a transient rise in CR3 activity. We suggest that PMNs control adhesivity by controlling synthesis of IMF-1, which then acts as an allosteric activator of leukocyte integrins. IMF-1 is an acidic, amphiphilic molecule of Mr340 ± 16 that does not contain ester, phosphate, amide, sialic acid, or glycosidic or vicinal hydroxyl functionalities, but does contain a carbon-carbon double bond. These results suggest that IMF-1 is an unsaturated fatty acid or an isoprenoid acid.

Original languageEnglish
Pages (from-to)341-352
Number of pages12
Issue number2
Publication statusPublished - 24 Jan 1992


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