Insights into Androgen Receptor Action in Lung Cancer

Darko Durovski; Milica Jankovic; Stefan Prekovic

doi:10.3390/endocrines4020022

Insights into Androgen Receptor Action in Lung Cancer

Darko Durovski, Milica Jankovic, Stefan Prekovic^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Sex hormones and their receptors play a crucial role in human sexual dimorphism and have been traditionally associated with hormone-dependent cancers like breast, prostate, and endometrial cancer. However, recent research has broadened our understanding by revealing connections with other types of cancers, such as lung cancer, where the androgen receptor has been found to be particularly significant. This review aims to explore the molecular mechanisms of androgen action in lung cancer pathogenesis and progression, highlighting the potential of inhibiting the androgen receptor signaling pathway as a therapeutic strategy for lung cancer treatment.

Original language	English
Pages (from-to)	269-280
Number of pages	12
Journal	Endocrines
Volume	4
Issue number	2
DOIs	https://doi.org/10.3390/endocrines4020022
Publication status	Published - Jun 2023

Keywords

androgens
lung cancer
nuclear receptors

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10.3390/endocrines4020022Licence: CC BY

endocrines-04-00022Final published version, 1.52 MBLicence: CC BY

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title = "Insights into Androgen Receptor Action in Lung Cancer",

abstract = "Sex hormones and their receptors play a crucial role in human sexual dimorphism and have been traditionally associated with hormone-dependent cancers like breast, prostate, and endometrial cancer. However, recent research has broadened our understanding by revealing connections with other types of cancers, such as lung cancer, where the androgen receptor has been found to be particularly significant. This review aims to explore the molecular mechanisms of androgen action in lung cancer pathogenesis and progression, highlighting the potential of inhibiting the androgen receptor signaling pathway as a therapeutic strategy for lung cancer treatment.",

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author = "Darko Durovski and Milica Jankovic and Stefan Prekovic",

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AU - Durovski, Darko

AU - Jankovic, Milica

AU - Prekovic, Stefan

PY - 2023/6

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N2 - Sex hormones and their receptors play a crucial role in human sexual dimorphism and have been traditionally associated with hormone-dependent cancers like breast, prostate, and endometrial cancer. However, recent research has broadened our understanding by revealing connections with other types of cancers, such as lung cancer, where the androgen receptor has been found to be particularly significant. This review aims to explore the molecular mechanisms of androgen action in lung cancer pathogenesis and progression, highlighting the potential of inhibiting the androgen receptor signaling pathway as a therapeutic strategy for lung cancer treatment.

AB - Sex hormones and their receptors play a crucial role in human sexual dimorphism and have been traditionally associated with hormone-dependent cancers like breast, prostate, and endometrial cancer. However, recent research has broadened our understanding by revealing connections with other types of cancers, such as lung cancer, where the androgen receptor has been found to be particularly significant. This review aims to explore the molecular mechanisms of androgen action in lung cancer pathogenesis and progression, highlighting the potential of inhibiting the androgen receptor signaling pathway as a therapeutic strategy for lung cancer treatment.

KW - androgens

KW - lung cancer

KW - nuclear receptors

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U2 - 10.3390/endocrines4020022

DO - 10.3390/endocrines4020022

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JO - Endocrines

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Insights into Androgen Receptor Action in Lung Cancer

Abstract

Keywords

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