Innovations in craniofacial bone and periodontal tissue engineering–from electrospinning to converged biofabrication

Zeynep Aytac; Nileshkumar Dubey; Arwa Daghrery; Jessica A. Ferreira; Isaac J. de Souza Araújo; Miguel Castilho; Jos Malda; Marco C. Bottino

doi:10.1080/09506608.2021.1946236

Innovations in craniofacial bone and periodontal tissue engineering–from electrospinning to converged biofabrication

Zeynep Aytac
, Nileshkumar Dubey
, Arwa Daghrery
, Jessica A. Ferreira
, Isaac J. de Souza Araújo
, Miguel Castilho
, Jos Malda
, Marco C. Bottino^*

^*Corresponding author for this work

Regenerative Medicine and Stem Cells

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

From a materials perspective, the pillars for the development of clinically translatable scaffold-based strategies for craniomaxillofacial (CMF) bone and periodontal regeneration have included electrospinning and 3D printing (biofabrication) technologies. Here, we offer a detailed analysis of the latest innovations in 3D (bio)printing strategies for CMF bone and periodontal regeneration and provide future directions envisioning the development of advanced 3D architectures for successful clinical translation. First, the principles of electrospinning applied to the generation of biodegradable scaffolds are discussed. Next, we present on extrusion-based 3D printing technologies with a focus on creating scaffolds with improved regenerative capacity. In addition, we offer a critical appraisal on 3D (bio)printing and multitechnology convergence to enable the reconstruction of CMF bones and periodontal tissues. As a future outlook, we highlight future directions associated with the utilization of complementary biomaterials and (bio)fabrication technologies for effective translation of personalized and functional scaffolds into the clinics.

Original language	English
Pages (from-to)	347-384
Number of pages	38
Journal	International Materials Reviews
Volume	67
Issue number	4
Early online date	3 Jul 2021
DOIs	https://doi.org/10.1080/09506608.2021.1946236
Publication status	Published - 19 May 2022

Keywords

3D printing
additive manufacturing
biofabrication
bioprinting
bone regeneration
craniomaxillofacial regeneration
Electrospinning
extrusion printing
periodontal regeneration

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10.1080/09506608.2021.1946236

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@article{d4ac53ea485f46baba9ddccf5f7189af,

title = "Innovations in craniofacial bone and periodontal tissue engineering–from electrospinning to converged biofabrication",

abstract = "From a materials perspective, the pillars for the development of clinically translatable scaffold-based strategies for craniomaxillofacial (CMF) bone and periodontal regeneration have included electrospinning and 3D printing (biofabrication) technologies. Here, we offer a detailed analysis of the latest innovations in 3D (bio)printing strategies for CMF bone and periodontal regeneration and provide future directions envisioning the development of advanced 3D architectures for successful clinical translation. First, the principles of electrospinning applied to the generation of biodegradable scaffolds are discussed. Next, we present on extrusion-based 3D printing technologies with a focus on creating scaffolds with improved regenerative capacity. In addition, we offer a critical appraisal on 3D (bio)printing and multitechnology convergence to enable the reconstruction of CMF bones and periodontal tissues. As a future outlook, we highlight future directions associated with the utilization of complementary biomaterials and (bio)fabrication technologies for effective translation of personalized and functional scaffolds into the clinics.",

keywords = "3D printing, additive manufacturing, biofabrication, bioprinting, bone regeneration, craniomaxillofacial regeneration, Electrospinning, extrusion printing, periodontal regeneration",

author = "Zeynep Aytac and Nileshkumar Dubey and Arwa Daghrery and Ferreira, \{Jessica A.\} and \{de Souza Ara{\'u}jo\}, \{Isaac J.\} and Miguel Castilho and Jos Malda and Bottino, \{Marco C.\}",

note = "Funding Information: This project was supported by funding from the National Institutes of Health (NIH), National Institute of Dental and Craniofacial Research [grant numbers K08DE023552 and R01DE026578 to MCB], the Osteology Foundation [Advanced Researcher Award], Osteo Science Foundation US [Peter Geistlich Research Award], the International Association for Dental Research [IADR-GSK Innovation in Oral Care Award and IADR-AO Implant Sciences Award], the American Academy of Implant Dentistry Foundation, the European Union H2020 program BRAVE [grant number 874827] and the Gravitation Program ?Materials Driven Regeneration? by the Netherlands Organization for Scientific Research [grant number 024.003.013]. The authors are grateful for the images and cartoons designed by Kenneth Rieger (Multimedia Designer, Department, School of Dentistry, University of Michigan, Ann Arbor, MI, USA). Publisher Copyright: {\textcopyright} 2021 Institute of Materials, Minerals and Mining and ASM International Published by Taylor \& Francis on behalf of the Institute and ASM International.",

year = "2022",

month = may,

day = "19",

doi = "10.1080/09506608.2021.1946236",

language = "English",

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journal = "International Materials Reviews",

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AU - Aytac, Zeynep

AU - Dubey, Nileshkumar

AU - Daghrery, Arwa

AU - Ferreira, Jessica A.

AU - de Souza Araújo, Isaac J.

AU - Castilho, Miguel

AU - Malda, Jos

AU - Bottino, Marco C.

N1 - Funding Information: This project was supported by funding from the National Institutes of Health (NIH), National Institute of Dental and Craniofacial Research [grant numbers K08DE023552 and R01DE026578 to MCB], the Osteology Foundation [Advanced Researcher Award], Osteo Science Foundation US [Peter Geistlich Research Award], the International Association for Dental Research [IADR-GSK Innovation in Oral Care Award and IADR-AO Implant Sciences Award], the American Academy of Implant Dentistry Foundation, the European Union H2020 program BRAVE [grant number 874827] and the Gravitation Program ?Materials Driven Regeneration? by the Netherlands Organization for Scientific Research [grant number 024.003.013]. The authors are grateful for the images and cartoons designed by Kenneth Rieger (Multimedia Designer, Department, School of Dentistry, University of Michigan, Ann Arbor, MI, USA). Publisher Copyright: © 2021 Institute of Materials, Minerals and Mining and ASM International Published by Taylor & Francis on behalf of the Institute and ASM International.

PY - 2022/5/19

Y1 - 2022/5/19

N2 - From a materials perspective, the pillars for the development of clinically translatable scaffold-based strategies for craniomaxillofacial (CMF) bone and periodontal regeneration have included electrospinning and 3D printing (biofabrication) technologies. Here, we offer a detailed analysis of the latest innovations in 3D (bio)printing strategies for CMF bone and periodontal regeneration and provide future directions envisioning the development of advanced 3D architectures for successful clinical translation. First, the principles of electrospinning applied to the generation of biodegradable scaffolds are discussed. Next, we present on extrusion-based 3D printing technologies with a focus on creating scaffolds with improved regenerative capacity. In addition, we offer a critical appraisal on 3D (bio)printing and multitechnology convergence to enable the reconstruction of CMF bones and periodontal tissues. As a future outlook, we highlight future directions associated with the utilization of complementary biomaterials and (bio)fabrication technologies for effective translation of personalized and functional scaffolds into the clinics.

AB - From a materials perspective, the pillars for the development of clinically translatable scaffold-based strategies for craniomaxillofacial (CMF) bone and periodontal regeneration have included electrospinning and 3D printing (biofabrication) technologies. Here, we offer a detailed analysis of the latest innovations in 3D (bio)printing strategies for CMF bone and periodontal regeneration and provide future directions envisioning the development of advanced 3D architectures for successful clinical translation. First, the principles of electrospinning applied to the generation of biodegradable scaffolds are discussed. Next, we present on extrusion-based 3D printing technologies with a focus on creating scaffolds with improved regenerative capacity. In addition, we offer a critical appraisal on 3D (bio)printing and multitechnology convergence to enable the reconstruction of CMF bones and periodontal tissues. As a future outlook, we highlight future directions associated with the utilization of complementary biomaterials and (bio)fabrication technologies for effective translation of personalized and functional scaffolds into the clinics.

KW - 3D printing

KW - additive manufacturing

KW - biofabrication

KW - bioprinting

KW - bone regeneration

KW - craniomaxillofacial regeneration

KW - Electrospinning

KW - extrusion printing

KW - periodontal regeneration

UR - https://www.scopus.com/pages/publications/85109980673

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DO - 10.1080/09506608.2021.1946236

M3 - Article

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SP - 347

EP - 384

JO - International Materials Reviews

JF - International Materials Reviews

IS - 4

ER -

Innovations in craniofacial bone and periodontal tissue engineering–from electrospinning to converged biofabrication

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