Influenza-geassocieerde acute necrotiserende encefalitis

Roel L N Huijsmans; Annemarije Braber; Christiaan Fokke; Jerome R Lo Ten Foe; Marnix Kuindersma

Influenza-geassocieerde acute necrotiserende encefalitis

Translated title of the contribution: Influenza-associated acute necrotizing encephalitis: unknown makes undertreated?

Roel L N Huijsmans
, Annemarije Braber
, Christiaan Fokke
, Jerome R Lo Ten Foe
, Marnix Kuindersma

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Influenza-associated acute necrotizing encephalitis (ANE) is a very rare, but severe complication from influenza infection.

CASE DESCRIPTION: We present a 48 year old male who presented with fever, malaise, confusion and altered mental status (E4M5V2) and influenza A infection. He quickly develops convulsions after which he is intubated and admitted to the Intensive Care Unit following which he remains comatose (E1M1V1). The diagnosis of influenza associated acute necrotizing encephalitis is made based on his neurological symptoms, generalized slowing on electro-encephalogram, classic bilateral findings on MRI in the thalamus and basal ganglia and proven influenza infection in the cerebrospinal fluid.

CONCLUSION: Acute necrotising encephalitis is a severe complication from a common infection. It is advised to consider early MRI imaging in patients with influenza and fitting neurological symptoms and to consider treatment with corticosteroids.

Translated title of the contribution	Influenza-associated acute necrotizing encephalitis: unknown makes undertreated?
Original language	Dutch
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	167
Publication status	Published - 23 Nov 2023
Externally published	Yes

Keywords

Male
Humans
Middle Aged
Influenza, Human/complications
Leukoencephalitis, Acute Hemorrhagic
Coma
Confusion
Fever

Cite this

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title = "Influenza-geassocieerde acute necrotiserende encefalitis",

abstract = "BACKGROUND: Influenza-associated acute necrotizing encephalitis (ANE) is a very rare, but severe complication from influenza infection.CASE DESCRIPTION: We present a 48 year old male who presented with fever, malaise, confusion and altered mental status (E4M5V2) and influenza A infection. He quickly develops convulsions after which he is intubated and admitted to the Intensive Care Unit following which he remains comatose (E1M1V1). The diagnosis of influenza associated acute necrotizing encephalitis is made based on his neurological symptoms, generalized slowing on electro-encephalogram, classic bilateral findings on MRI in the thalamus and basal ganglia and proven influenza infection in the cerebrospinal fluid.CONCLUSION: Acute necrotising encephalitis is a severe complication from a common infection. It is advised to consider early MRI imaging in patients with influenza and fitting neurological symptoms and to consider treatment with corticosteroids.",

keywords = "Male, Humans, Middle Aged, Influenza, Human/complications, Leukoencephalitis, Acute Hemorrhagic, Coma, Confusion, Fever",

author = "Huijsmans, \{Roel L N\} and Annemarije Braber and Christiaan Fokke and \{Lo Ten Foe\}, \{Jerome R\} and Marnix Kuindersma",

year = "2023",

month = nov,

day = "23",

language = "Dutch",

volume = "167",

journal = "Nederlands Tijdschrift voor Geneeskunde",

issn = "0028-2162",

publisher = "Vereniging Nederlands Tijdschrift voor Geneeskunde",

}

TY - JOUR

T1 - Influenza-geassocieerde acute necrotiserende encefalitis

AU - Huijsmans, Roel L N

AU - Braber, Annemarije

AU - Fokke, Christiaan

AU - Lo Ten Foe, Jerome R

AU - Kuindersma, Marnix

PY - 2023/11/23

Y1 - 2023/11/23

N2 - BACKGROUND: Influenza-associated acute necrotizing encephalitis (ANE) is a very rare, but severe complication from influenza infection.CASE DESCRIPTION: We present a 48 year old male who presented with fever, malaise, confusion and altered mental status (E4M5V2) and influenza A infection. He quickly develops convulsions after which he is intubated and admitted to the Intensive Care Unit following which he remains comatose (E1M1V1). The diagnosis of influenza associated acute necrotizing encephalitis is made based on his neurological symptoms, generalized slowing on electro-encephalogram, classic bilateral findings on MRI in the thalamus and basal ganglia and proven influenza infection in the cerebrospinal fluid.CONCLUSION: Acute necrotising encephalitis is a severe complication from a common infection. It is advised to consider early MRI imaging in patients with influenza and fitting neurological symptoms and to consider treatment with corticosteroids.

AB - BACKGROUND: Influenza-associated acute necrotizing encephalitis (ANE) is a very rare, but severe complication from influenza infection.CASE DESCRIPTION: We present a 48 year old male who presented with fever, malaise, confusion and altered mental status (E4M5V2) and influenza A infection. He quickly develops convulsions after which he is intubated and admitted to the Intensive Care Unit following which he remains comatose (E1M1V1). The diagnosis of influenza associated acute necrotizing encephalitis is made based on his neurological symptoms, generalized slowing on electro-encephalogram, classic bilateral findings on MRI in the thalamus and basal ganglia and proven influenza infection in the cerebrospinal fluid.CONCLUSION: Acute necrotising encephalitis is a severe complication from a common infection. It is advised to consider early MRI imaging in patients with influenza and fitting neurological symptoms and to consider treatment with corticosteroids.

KW - Male

KW - Humans

KW - Middle Aged

KW - Influenza, Human/complications

KW - Leukoencephalitis, Acute Hemorrhagic

KW - Coma

KW - Confusion

KW - Fever

M3 - Article

C2 - 38175574

SN - 0028-2162

VL - 167

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

ER -

Influenza-geassocieerde acute necrotiserende encefalitis

Abstract

Keywords

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