Abstract
OBJECTIVE: It has recently been observed that non-inherited maternal DR4 antigens (NIMAs) of DR4 negative rheumatoid arthritis (RA) patients were increased compared with non-inherited paternal DR4 antigens (NIPAs). The aim of this study was to determine the prevalence of non-inherited DR4 antigens and DRB1 alleles in parents of RA patients.
METHODS: HLA-DR serology and DRB1 typing was performed in 97 RA patients and their parents. NIMA and NIPA frequencies were compared, stratified according to the presence of DR4 and/or the shared epitope (SE).
RESULTS: In DR4 negative patients, NIMA DR4 was increased compared with NIPA DR4 (OR 3.10, 95% CI 0.76, 12.70). When combined with results from a previous study this increase was significant (OR 3.65, 95% CI 1.29, 10.31). The NIMA effect of SE positive DR4 subtypes in this study (OR 4.73, 95% CI 0.94, 23.8) was stronger than the NIMA effect of combined SE positive DRB1 alleles (OR 2.19 95% CI 0.36, 13.22).
CONCLUSIONS: The association between non-inherited maternal HLA-DR4 alleles and the susceptibility to RA was observed in two independent populations.
| Original language | English |
|---|---|
| Pages (from-to) | 672-5 |
| Number of pages | 4 |
| Journal | Annals of the Rheumatic Diseases |
| Volume | 57 |
| Issue number | 11 |
| Publication status | Published - Nov 1998 |
Keywords
- Adolescent
- Adult
- Alleles
- Arthritis, Rheumatoid
- Case-Control Studies
- Fathers
- Female
- Genetic Predisposition to Disease
- HLA-DR Antigens
- HLA-DR4 Antigen
- HLA-DRB1 Chains
- Histocompatibility Testing
- Humans
- Male
- Middle Aged
- Mothers
- Journal Article