Inflammatory mediators in childhood chronic diseases: A three-tiered approach

G.C.E. Keustermans

Inflammatory mediators in childhood chronic diseases: A three-tiered approach

G.C.E. Keustermans

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Abstract

Acute inflammation is the bodies short term primary response to detrimental stimuli. If left unresolved however, acute inflammation may enter a longer term and chronic phase: chronic inflammation. This thesis has endeavoured to understand and dissect the role of various key players in the context of chronic paediatric inflammation by using a three-tiered approach: cytokines, extracellular vesicles (EVs) and immune cells. By discerning the role and postulating the relevance of each tier, this body of work attempts to clarify old and provide new insights into understanding and manipulating the chronic inflammatory state.

Original language	English
Awarding Institution	University Medical Center (UMC) Utrecht
Supervisors/Advisors	Prakken, Berent, Primary supervisor Pasterkamp, Gerard, Supervisor de Jager, W., Co-supervisor Schipper, H.S., Co-supervisor
Award date	26 Jun 2018
Publisher	Utrecht University
Print ISBNs	978-94-6295-961-3
Publication status	Published - 26 Jun 2018

Keywords

Chronic inflammation
Cytokines
Adipokine receptors
Extracellular vesicles
Monocytes  
Gene expression
Obesity
Cardiovascular disease
Juvenile Idiopathic arthritis
Immune cell metabolism

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title = "Inflammatory mediators in childhood chronic diseases: A three-tiered approach",

abstract = "Acute inflammation is the bodies short term primary response to detrimental stimuli. If left unresolved however, acute inflammation may enter a longer term and chronic phase: chronic inflammation. This thesis has endeavoured to understand and dissect the role of various key players in the context of chronic paediatric inflammation by using a three-tiered approach: cytokines, extracellular vesicles (EVs) and immune cells. By discerning the role and postulating the relevance of each tier, this body of work attempts to clarify old and provide new insights into understanding and manipulating the chronic inflammatory state.",

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year = "2018",

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day = "26",

language = "English",

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type = "Doctoral thesis 1 (Research UU / Graduation UU)",

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T1 - Inflammatory mediators in childhood chronic diseases

T2 - A three-tiered approach

AU - Keustermans, G.C.E.

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Y1 - 2018/6/26

N2 - Acute inflammation is the bodies short term primary response to detrimental stimuli. If left unresolved however, acute inflammation may enter a longer term and chronic phase: chronic inflammation. This thesis has endeavoured to understand and dissect the role of various key players in the context of chronic paediatric inflammation by using a three-tiered approach: cytokines, extracellular vesicles (EVs) and immune cells. By discerning the role and postulating the relevance of each tier, this body of work attempts to clarify old and provide new insights into understanding and manipulating the chronic inflammatory state.

AB - Acute inflammation is the bodies short term primary response to detrimental stimuli. If left unresolved however, acute inflammation may enter a longer term and chronic phase: chronic inflammation. This thesis has endeavoured to understand and dissect the role of various key players in the context of chronic paediatric inflammation by using a three-tiered approach: cytokines, extracellular vesicles (EVs) and immune cells. By discerning the role and postulating the relevance of each tier, this body of work attempts to clarify old and provide new insights into understanding and manipulating the chronic inflammatory state.

KW - Chronic inflammation

KW - Cytokines

KW - Adipokine receptors

KW - Extracellular vesicles

KW - Monocytes  

KW - Gene expression

KW - Obesity

KW - Cardiovascular disease

KW - Juvenile Idiopathic arthritis

KW - Immune cell metabolism

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-94-6295-961-3

PB - Utrecht University

ER -

Inflammatory mediators in childhood chronic diseases: A three-tiered approach

Abstract

Keywords

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