Inflammatory Markers and Risk of Epithelial Ovarian Cancer by Tumor Subtypes: The EPIC Cohort

Jennifer Ose; Helena Schock; Anne Tjonneland; Louise Hansen; Kim Overvad; Laure Dossus; Francoise Clavel-Chapelon; Laura Baglietto; Heiner Boeing; Antonia Trichopolou; Vassiliki Benetou; Pagona Lagiou; Giovanna Masala; Giovanna Tagliabue; Rosario Tumino; Carlotta Sacerdote; Amalia Mattiello; H. B(As) Bueno-de-Mesquita; Petra H. M. Peeters; N. Charlotte Onland-Moret; Elisabete Weiderpass; Inger T. Gram; Soledad Sanchez; Mireia Obon-Santacana; Maria-Jose Sanchez-Perez; Nerea Larranaga; Jose Mara Huerta Castano; Eva Ardanaz; Jenny Brandstedt; Eva Lundin; Annika Idahl; Ruth C. Travis; Kay-Tee Khaw; Sabina Rinaldi; Isabelle Romieu; Melissa A. Merritt; Marc J. Gunter; Elio Riboli; Rudolf Kaaks; Renee T. Fortner

doi:10.1158/1055-9965.EPI-14-1279-T

Inflammatory Markers and Risk of Epithelial Ovarian Cancer by Tumor Subtypes: The EPIC Cohort

Jennifer Ose, Helena Schock, Anne Tjonneland, Louise Hansen, Kim Overvad, Laure Dossus, Francoise Clavel-Chapelon, Laura Baglietto, Heiner Boeing, Antonia Trichopolou, Vassiliki Benetou, Pagona Lagiou, Giovanna Masala, Giovanna Tagliabue, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, H. B(As) Bueno-de-Mesquita, Petra H. M. Peeters, N. Charlotte Onland-MoretElisabete Weiderpass, Inger T. Gram, Soledad Sanchez, Mireia Obon-Santacana, Maria-Jose Sanchez-Perez, Nerea Larranaga, Jose Mara Huerta Castano, Eva Ardanaz, Jenny Brandstedt, Eva Lundin, Annika Idahl, Ruth C. Travis, Kay-Tee Khaw, Sabina Rinaldi, Isabelle Romieu, Melissa A. Merritt, Marc J. Gunter, Elio Riboli, Rudolf Kaaks, Renee T. Fortner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Evidence suggests an etiologic role for inflammation in ovarian carcinogenesis and heterogeneity between tumor subtypes and anthropometric indices. Prospective studies on circulating inflammatory markers and epithelial invasive ovarian cancer (EOC) have predominantly investigated overall risk; data characterizing risk by tumor characteristics (histology, grade, stage, dualistic model of ovarian carcinogenesis) and anthropometric indices are sparse.

Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate C-reactive protein (CRP), IL6, and EOC risk by tumor characteristics. A total of 754 eligible EOC cases were identified; two controls (n = 1,497) were matched per case. We used multivariable conditional logistic regression to assess associations.

Results: CRP and IL6 were not associated with overall EOC risk. However, consistent with prior research, CRP >10 versus CRP 88: ORlog2, 1.78 (1.28-2.48), P-heterogeneity

Conclusions: Our data suggest that high CRP is associated with increased risk of overall EOC, and that IL6 and CRP may be associated with EOC risk among women with higher adiposity.

Original language	English
Pages (from-to)	951-961
Number of pages	11
Journal	Cancer Epidemiology Biomarkers & Prevention
Volume	24
Issue number	6
DOIs	https://doi.org/10.1158/1055-9965.EPI-14-1279-T
Publication status	Published - Jun 2015

Keywords

C-REACTIVE PROTEIN
BREAST-CANCER
ANTHROPOMETRIC MEASURES
MOLECULAR PATHOGENESIS
PHYSICAL-ACTIVITY
CENTRAL ADIPOSITY
BODY-SIZE
WOMEN
OBESITY
SERUM

Access to Document

10.1158/1055-9965.EPI-14-1279-T

Cite this

Ose, J., Schock, H., Tjonneland, A., Hansen, L., Overvad, K., Dossus, L., Clavel-Chapelon, F., Baglietto, L., Boeing, H., Trichopolou, A., Benetou, V., Lagiou, P., Masala, G., Tagliabue, G., Tumino, R., Sacerdote, C., Mattiello, A., Bueno-de-Mesquita, H. BA., Peeters, P. H. M., ... Fortner, R. T. (2015). Inflammatory Markers and Risk of Epithelial Ovarian Cancer by Tumor Subtypes: The EPIC Cohort. Cancer Epidemiology Biomarkers & Prevention, 24(6), 951-961. https://doi.org/10.1158/1055-9965.EPI-14-1279-T

@article{e6fce51e991c4910a4a4d37a053f5981,

title = "Inflammatory Markers and Risk of Epithelial Ovarian Cancer by Tumor Subtypes: The EPIC Cohort",

abstract = "Background: Evidence suggests an etiologic role for inflammation in ovarian carcinogenesis and heterogeneity between tumor subtypes and anthropometric indices. Prospective studies on circulating inflammatory markers and epithelial invasive ovarian cancer (EOC) have predominantly investigated overall risk; data characterizing risk by tumor characteristics (histology, grade, stage, dualistic model of ovarian carcinogenesis) and anthropometric indices are sparse.Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate C-reactive protein (CRP), IL6, and EOC risk by tumor characteristics. A total of 754 eligible EOC cases were identified; two controls (n = 1,497) were matched per case. We used multivariable conditional logistic regression to assess associations.Results: CRP and IL6 were not associated with overall EOC risk. However, consistent with prior research, CRP >10 versus CRP 88: ORlog2, 1.78 (1.28-2.48), P-heterogeneityConclusions: Our data suggest that high CRP is associated with increased risk of overall EOC, and that IL6 and CRP may be associated with EOC risk among women with higher adiposity.Impact: Our data add to global evidence that ovarian carcinogenesis may be promoted by an inflammatory milieu. (C)2015 AACR.",

keywords = "C-REACTIVE PROTEIN, BREAST-CANCER, ANTHROPOMETRIC MEASURES, MOLECULAR PATHOGENESIS, PHYSICAL-ACTIVITY, CENTRAL ADIPOSITY, BODY-SIZE, WOMEN, OBESITY, SERUM",

author = "Jennifer Ose and Helena Schock and Anne Tjonneland and Louise Hansen and Kim Overvad and Laure Dossus and Francoise Clavel-Chapelon and Laura Baglietto and Heiner Boeing and Antonia Trichopolou and Vassiliki Benetou and Pagona Lagiou and Giovanna Masala and Giovanna Tagliabue and Rosario Tumino and Carlotta Sacerdote and Amalia Mattiello and Bueno-de-Mesquita, {H. B(As)} and Peeters, {Petra H. M.} and Onland-Moret, {N. Charlotte} and Elisabete Weiderpass and Gram, {Inger T.} and Soledad Sanchez and Mireia Obon-Santacana and Maria-Jose Sanchez-Perez and Nerea Larranaga and {Huerta Castano}, {Jose Mara} and Eva Ardanaz and Jenny Brandstedt and Eva Lundin and Annika Idahl and Travis, {Ruth C.} and Kay-Tee Khaw and Sabina Rinaldi and Isabelle Romieu and Merritt, {Melissa A.} and Gunter, {Marc J.} and Elio Riboli and Rudolf Kaaks and Fortner, {Renee T.}",

year = "2015",

month = jun,

doi = "10.1158/1055-9965.EPI-14-1279-T",

language = "English",

volume = "24",

pages = "951--961",

journal = "Cancer Epidemiology Biomarkers & Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

number = "6",

}

Ose, J, Schock, H, Tjonneland, A, Hansen, L, Overvad, K, Dossus, L, Clavel-Chapelon, F, Baglietto, L, Boeing, H, Trichopolou, A, Benetou, V, Lagiou, P, Masala, G, Tagliabue, G, Tumino, R, Sacerdote, C, Mattiello, A, Bueno-de-Mesquita, HBA, Peeters, PHM, Onland-Moret, NC, Weiderpass, E, Gram, IT, Sanchez, S, Obon-Santacana, M, Sanchez-Perez, M-J, Larranaga, N, Huerta Castano, JM, Ardanaz, E, Brandstedt, J, Lundin, E, Idahl, A, Travis, RC, Khaw, K-T, Rinaldi, S, Romieu, I, Merritt, MA, Gunter, MJ, Riboli, E, Kaaks, R & Fortner, RT 2015, 'Inflammatory Markers and Risk of Epithelial Ovarian Cancer by Tumor Subtypes: The EPIC Cohort', Cancer Epidemiology Biomarkers & Prevention, vol. 24, no. 6, pp. 951-961. https://doi.org/10.1158/1055-9965.EPI-14-1279-T

TY - JOUR

T1 - Inflammatory Markers and Risk of Epithelial Ovarian Cancer by Tumor Subtypes

T2 - The EPIC Cohort

AU - Ose, Jennifer

AU - Schock, Helena

AU - Tjonneland, Anne

AU - Hansen, Louise

AU - Overvad, Kim

AU - Dossus, Laure

AU - Clavel-Chapelon, Francoise

AU - Baglietto, Laura

AU - Boeing, Heiner

AU - Trichopolou, Antonia

AU - Benetou, Vassiliki

AU - Lagiou, Pagona

AU - Masala, Giovanna

AU - Tagliabue, Giovanna

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Mattiello, Amalia

AU - Bueno-de-Mesquita, H. B(As)

AU - Peeters, Petra H. M.

AU - Onland-Moret, N. Charlotte

AU - Weiderpass, Elisabete

AU - Gram, Inger T.

AU - Sanchez, Soledad

AU - Obon-Santacana, Mireia

AU - Sanchez-Perez, Maria-Jose

AU - Larranaga, Nerea

AU - Huerta Castano, Jose Mara

AU - Ardanaz, Eva

AU - Brandstedt, Jenny

AU - Lundin, Eva

AU - Idahl, Annika

AU - Travis, Ruth C.

AU - Khaw, Kay-Tee

AU - Rinaldi, Sabina

AU - Romieu, Isabelle

AU - Merritt, Melissa A.

AU - Gunter, Marc J.

AU - Riboli, Elio

AU - Kaaks, Rudolf

AU - Fortner, Renee T.

PY - 2015/6

Y1 - 2015/6

N2 - Background: Evidence suggests an etiologic role for inflammation in ovarian carcinogenesis and heterogeneity between tumor subtypes and anthropometric indices. Prospective studies on circulating inflammatory markers and epithelial invasive ovarian cancer (EOC) have predominantly investigated overall risk; data characterizing risk by tumor characteristics (histology, grade, stage, dualistic model of ovarian carcinogenesis) and anthropometric indices are sparse.Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate C-reactive protein (CRP), IL6, and EOC risk by tumor characteristics. A total of 754 eligible EOC cases were identified; two controls (n = 1,497) were matched per case. We used multivariable conditional logistic regression to assess associations.Results: CRP and IL6 were not associated with overall EOC risk. However, consistent with prior research, CRP >10 versus CRP 88: ORlog2, 1.78 (1.28-2.48), P-heterogeneityConclusions: Our data suggest that high CRP is associated with increased risk of overall EOC, and that IL6 and CRP may be associated with EOC risk among women with higher adiposity.Impact: Our data add to global evidence that ovarian carcinogenesis may be promoted by an inflammatory milieu. (C)2015 AACR.

AB - Background: Evidence suggests an etiologic role for inflammation in ovarian carcinogenesis and heterogeneity between tumor subtypes and anthropometric indices. Prospective studies on circulating inflammatory markers and epithelial invasive ovarian cancer (EOC) have predominantly investigated overall risk; data characterizing risk by tumor characteristics (histology, grade, stage, dualistic model of ovarian carcinogenesis) and anthropometric indices are sparse.Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate C-reactive protein (CRP), IL6, and EOC risk by tumor characteristics. A total of 754 eligible EOC cases were identified; two controls (n = 1,497) were matched per case. We used multivariable conditional logistic regression to assess associations.Results: CRP and IL6 were not associated with overall EOC risk. However, consistent with prior research, CRP >10 versus CRP 88: ORlog2, 1.78 (1.28-2.48), P-heterogeneityConclusions: Our data suggest that high CRP is associated with increased risk of overall EOC, and that IL6 and CRP may be associated with EOC risk among women with higher adiposity.Impact: Our data add to global evidence that ovarian carcinogenesis may be promoted by an inflammatory milieu. (C)2015 AACR.

KW - C-REACTIVE PROTEIN

KW - BREAST-CANCER

KW - ANTHROPOMETRIC MEASURES

KW - MOLECULAR PATHOGENESIS

KW - PHYSICAL-ACTIVITY

KW - CENTRAL ADIPOSITY

KW - BODY-SIZE

KW - WOMEN

KW - OBESITY

KW - SERUM

U2 - 10.1158/1055-9965.EPI-14-1279-T

DO - 10.1158/1055-9965.EPI-14-1279-T

M3 - Article

C2 - 25855626

SN - 1055-9965

VL - 24

SP - 951

EP - 961

JO - Cancer Epidemiology Biomarkers & Prevention

JF - Cancer Epidemiology Biomarkers & Prevention

IS - 6

ER -

Inflammatory Markers and Risk of Epithelial Ovarian Cancer by Tumor Subtypes: The EPIC Cohort

Abstract

Keywords

Access to Document

Fingerprint

Cite this