Induction of Salivary IgA and IgG Responses by Parenteral PPV23 Vaccination in Older Adults

Maxime Visser; Irina Tcherniaeva; Lia de Rond; Mary lène de Zeeuw-Brouwer; Monique W.M. Verschuren; Susan H.S.J. Picavet; Marien I. de Jonge; Gerco den Hartog; Anne Marie Buisman

doi:10.1093/ofid/ofag273

Induction of Salivary IgA and IgG Responses by Parenteral PPV23 Vaccination in Older Adults

Maxime Visser
, Irina Tcherniaeva
, Lia de Rond
, Mary lène de Zeeuw-Brouwer
, Monique W.M. Verschuren
, Susan H.S.J. Picavet
, Marien I. de Jonge
, Gerco den Hartog
, Anne Marie Buisman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Mucosal immunity restricts Streptococcus pneumoniae colonization, thereby reducing the risk of transmission and disease. This is the first study to demonstrate that parenteral 23-valent pneumococcal polysaccharide vaccine (PPV23) vaccination induces salivary IgA and IgG responses in older adults, aged 72–79, an age group at increased risk for pneumococcal disease.

Original language	English
Article number	ofag273
Journal	Open Forum Infectious Diseases
Volume	13
Issue number	5
DOIs	https://doi.org/10.1093/ofid/ofag273
Publication status	Published - May 2026

Keywords

antibodies
mucosal immunity
older adults
PPV23
saliva

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10.1093/ofid/ofag273Licence: CC BY

ofag273Final published version, 657 KBLicence: CC BY

Cite this

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title = "Induction of Salivary IgA and IgG Responses by Parenteral PPV23 Vaccination in Older Adults",

abstract = "Mucosal immunity restricts Streptococcus pneumoniae colonization, thereby reducing the risk of transmission and disease. This is the first study to demonstrate that parenteral 23-valent pneumococcal polysaccharide vaccine (PPV23) vaccination induces salivary IgA and IgG responses in older adults, aged 72–79, an age group at increased risk for pneumococcal disease.",

keywords = "antibodies, mucosal immunity, older adults, PPV23, saliva",

author = "Maxime Visser and Irina Tcherniaeva and \{de Rond\}, Lia and \{de Zeeuw-Brouwer\}, \{Mary l{\`e}ne\} and Verschuren, \{Monique W.M.\} and Picavet, \{Susan H.S.J.\} and \{de Jonge\}, \{Marien I.\} and \{den Hartog\}, Gerco and Buisman, \{Anne Marie\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2026. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.",

year = "2026",

month = may,

doi = "10.1093/ofid/ofag273",

language = "English",

volume = "13",

journal = "Open Forum Infectious Diseases",

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AU - Visser, Maxime

AU - Tcherniaeva, Irina

AU - de Rond, Lia

AU - de Zeeuw-Brouwer, Mary lène

AU - Verschuren, Monique W.M.

AU - Picavet, Susan H.S.J.

AU - de Jonge, Marien I.

AU - den Hartog, Gerco

AU - Buisman, Anne Marie

N1 - Publisher Copyright: © The Author(s) 2026. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2026/5

Y1 - 2026/5

N2 - Mucosal immunity restricts Streptococcus pneumoniae colonization, thereby reducing the risk of transmission and disease. This is the first study to demonstrate that parenteral 23-valent pneumococcal polysaccharide vaccine (PPV23) vaccination induces salivary IgA and IgG responses in older adults, aged 72–79, an age group at increased risk for pneumococcal disease.

AB - Mucosal immunity restricts Streptococcus pneumoniae colonization, thereby reducing the risk of transmission and disease. This is the first study to demonstrate that parenteral 23-valent pneumococcal polysaccharide vaccine (PPV23) vaccination induces salivary IgA and IgG responses in older adults, aged 72–79, an age group at increased risk for pneumococcal disease.

KW - antibodies

KW - mucosal immunity

KW - older adults

KW - PPV23

KW - saliva

UR - https://www.scopus.com/pages/publications/105039689378

U2 - 10.1093/ofid/ofag273

DO - 10.1093/ofid/ofag273

M3 - Article

AN - SCOPUS:105039689378

SN - 2328-8957

VL - 13

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 5

M1 - ofag273

ER -

Induction of Salivary IgA and IgG Responses by Parenteral PPV23 Vaccination in Older Adults

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