Induced Pluripotent Stem Cells

Alain van Mil*, Klaus Neef, Geerthe M. Balk, Jan Willem Buikema, Joost P.G. Sluijter, Pieter A.F.M. Doevendans

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

Progress in understanding and treatment of numerous human diseases has been hampered by the lack of representative human in vitro models, especially for diseases in which the affected cell types are difficult to obtain, such as heart diseases. Over the past decade, the use of disease affected cell types derived from induced pluripotent stem (iPS) cells has developed into a unique and powerful method to study the pathophysiological mechanisms of human cardiac disease and drive the development of novel targeted therapies. In this chapter, an overview is provided of the iPS-derived cardiomyocyte (iPS-CM) models for inherited cardiac disease that have been studied so far. In addition to the key findings of these individual studies and the progress that has been made since the first iPS-CM disease model, limitations and important methodological considerations are discussed. The current advances in iPS-CM disease modeling and the challenges yet to overcome show that this field holds great promise, but is still in its infancy.

Original languageEnglish
Title of host publicationClinical Cardiogenetics
Subtitle of host publicationThird Edition
PublisherSpringer International Publishing
Pages439-455
Number of pages17
ISBN (Electronic)9783030454579
ISBN (Print)9783030454562
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • Cardiac differentiation
  • Disease modeling
  • Induced pluripotent stem cells
  • Inherited cardiac disease
  • Pluripotent stem cell-derived cardiomyocytes
  • Precision medicine

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