Increased sensitivity of the chemoattractant-induced chemiluminescence in eosinophils isolated from atopic individuals

L. Koenderman; P. L B Bruijnzeel

Increased sensitivity of the chemoattractant-induced chemiluminescence in eosinophils isolated from atopic individuals

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15 Citations (Scopus)

Abstract

Eosinophilia in peripheral blood is a common phenomenon associated with atopic condition. The present study illustrates the enhanced sensitivity of these eosinophils for formyl-methionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF) (measured as luminol-enhanced chemiluminescence) compared with eosinophils located from the peripheral blood of normal individuals. The PAF-induced chemiluminescence, which is peroxidase dependent and of extracellular origin, is inhibited by the PAF antagonist BN52021. The enhanced sensitivity of eosinophils isolated from atopic patients for FMLP and PAF might reflect a 'primed' state of these cells, relevant for the pathogenesis of atopic disease.

Original language	English
Pages (from-to)	534-536
Number of pages	3
Journal	Immunology
Volume	67
Issue number	4
Publication status	Published - 1 Jan 1989

Cite this

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abstract = "Eosinophilia in peripheral blood is a common phenomenon associated with atopic condition. The present study illustrates the enhanced sensitivity of these eosinophils for formyl-methionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF) (measured as luminol-enhanced chemiluminescence) compared with eosinophils located from the peripheral blood of normal individuals. The PAF-induced chemiluminescence, which is peroxidase dependent and of extracellular origin, is inhibited by the PAF antagonist BN52021. The enhanced sensitivity of eosinophils isolated from atopic patients for FMLP and PAF might reflect a 'primed' state of these cells, relevant for the pathogenesis of atopic disease.",

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AU - Koenderman, L.

AU - Bruijnzeel, P. L B

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N2 - Eosinophilia in peripheral blood is a common phenomenon associated with atopic condition. The present study illustrates the enhanced sensitivity of these eosinophils for formyl-methionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF) (measured as luminol-enhanced chemiluminescence) compared with eosinophils located from the peripheral blood of normal individuals. The PAF-induced chemiluminescence, which is peroxidase dependent and of extracellular origin, is inhibited by the PAF antagonist BN52021. The enhanced sensitivity of eosinophils isolated from atopic patients for FMLP and PAF might reflect a 'primed' state of these cells, relevant for the pathogenesis of atopic disease.

AB - Eosinophilia in peripheral blood is a common phenomenon associated with atopic condition. The present study illustrates the enhanced sensitivity of these eosinophils for formyl-methionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF) (measured as luminol-enhanced chemiluminescence) compared with eosinophils located from the peripheral blood of normal individuals. The PAF-induced chemiluminescence, which is peroxidase dependent and of extracellular origin, is inhibited by the PAF antagonist BN52021. The enhanced sensitivity of eosinophils isolated from atopic patients for FMLP and PAF might reflect a 'primed' state of these cells, relevant for the pathogenesis of atopic disease.

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M3 - Article

C2 - 2767711

AN - SCOPUS:0024397506

SN - 0019-2805

VL - 67

SP - 534

EP - 536

JO - Immunology

JF - Immunology

IS - 4

ER -

Increased sensitivity of the chemoattractant-induced chemiluminescence in eosinophils isolated from atopic individuals

Abstract

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