Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren's syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?

Sofie L M Blokland; Maarten R Hillen; Catharina G K Wichers; Maili Zimmermann; Aike A Kruize; Timothy R D J Radstake; Jasper C A Broen; Joel A G van Roon

doi:10.1136/rmdopen-2018-000701

Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren's syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?

Sofie L M Blokland
, Maarten R Hillen
, Catharina G K Wichers
, Maili Zimmermann
, Aike A Kruize
, Timothy R D J Radstake
, Jasper C A Broen
, Joel A G van Roon

Research output: Contribution to journal › Article › Academic › peer-review

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Original language	English
Article number	e000701
Journal	RMD Open
Volume	5
Issue number	1
DOIs	https://doi.org/10.1136/rmdopen-2018-000701
Publication status	Published - 2019

Keywords

B cells
Sjögren's syndrome
T cells
mTOR
rapamycin

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10.1136/rmdopen-2018-000701

bloklandFinal published version, 2.65 MB

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Blokland, S. L. M., Hillen, M. R., Wichers, C. G. K., Zimmermann, M., Kruize, A. A., Radstake, T. R. D. J., Broen, J. C. A., & van Roon, J. A. G. (2019). Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren's syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology? RMD Open, 5(1), Article e000701. https://doi.org/10.1136/rmdopen-2018-000701

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title = "Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sj{\"o}gren's syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?",

keywords = "B cells, Sj{\"o}gren's syndrome, T cells, mTOR, rapamycin",

author = "Blokland, \{Sofie L M\} and Hillen, \{Maarten R\} and Wichers, \{Catharina G K\} and Maili Zimmermann and Kruize, \{Aike A\} and Radstake, \{Timothy R D J\} and Broen, \{Jasper C A\} and \{van Roon\}, \{Joel A G\}",

year = "2019",

doi = "10.1136/rmdopen-2018-000701",

language = "English",

volume = "5",

journal = "RMD Open",

issn = "2056-5933",

publisher = "BMJ Publishing Group",

number = "1",

}

Blokland, SLM, Hillen, MR, Wichers, CGK, Zimmermann, M, Kruize, AA, Radstake, TRDJ, Broen, JCA & van Roon, JAG 2019, 'Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren's syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?', RMD Open, vol. 5, no. 1, e000701. https://doi.org/10.1136/rmdopen-2018-000701

Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren's syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology? / Blokland, Sofie L M; Hillen, Maarten R; Wichers, Catharina G K et al.
In: RMD Open, Vol. 5, No. 1, e000701, 2019.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren's syndrome

T2 - mTOR inhibition as a novel therapeutic strategy to halt immunopathology?

AU - Blokland, Sofie L M

AU - Hillen, Maarten R

AU - Wichers, Catharina G K

AU - Zimmermann, Maili

AU - Kruize, Aike A

AU - Radstake, Timothy R D J

AU - Broen, Jasper C A

AU - van Roon, Joel A G

PY - 2019

Y1 - 2019

KW - B cells

KW - Sjögren's syndrome

KW - T cells

KW - mTOR

KW - rapamycin

UR - https://www.scopus.com/pages/publications/85059896037

U2 - 10.1136/rmdopen-2018-000701

DO - 10.1136/rmdopen-2018-000701

M3 - Article

C2 - 30713717

SN - 2056-5933

VL - 5

JO - RMD Open

JF - RMD Open

IS - 1

M1 - e000701

ER -

Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren's syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?

Keywords

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