Increased MR-guided high intensity focused ultrasound (MR-HIFU) sonication efficiency of uterine fibroids after carbetocin administration

Kimberley J Anneveldt; Heleen J van 't Oever; Inez M Verpalen; Ingrid M Nijholt; Wilbert Bartels; Jeroen R Dijkstra; Rolf D van den Hoed; Miranda van 't Veer-Ten Kate; Erwin de Boer; Sebastiaan Veersema; Judith A F Huirne; Joke M Schutte; Martijn F Boomsma

doi:10.1016/j.ejro.2022.100413

Increased MR-guided high intensity focused ultrasound (MR-HIFU) sonication efficiency of uterine fibroids after carbetocin administration

Kimberley J Anneveldt
, Heleen J van 't Oever
, Inez M Verpalen
, Ingrid M Nijholt
, Wilbert Bartels
, Jeroen R Dijkstra
, Rolf D van den Hoed
, Miranda van 't Veer-Ten Kate
, Erwin de Boer
, Sebastiaan Veersema
, Judith A F Huirne
, Joke M Schutte
, Martijn F Boomsma

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Purpose: We investigated whether administration of the long-acting uterus stimulant carbetocin increased intra-subject sonication efficiency during Magnetic Resonance image guided High Intensity Focused Ultrasound (MR-HIFU) treatment of uterine fibroids.

Method: In this prospective cohort study, thirty women with symptomatic uterine fibroids undergoing MR-HIFU treatment were included between January 2018 and January 2019. Treatment started with three sonications on one side of the uterine fibroid. Subsequently, one ampoule of 1 mL carbetocin (100 µg/mL) was administered intravenously and treatment continued with three sonications on the other side of the uterine fibroid. We compared the intra-subject sonication efficiency, in terms of Energy Efficiency Factor (EEF), thermal dose volume and sonication time to ablate one cm 3 of fibroid tissue, before and after carbetocin administration. Adverse events that occurred within 30 min after carbetocin administration were recorded.

Results: Sonication efficiency improved after carbetocin administration as indicated by a significant decrease in EEF and sonication time (p = 0.006 and p = 0.001 respectively), and a significant increase in thermal dose volume reached (p = <0.001). Five women (16.7%) experienced temporary tachycardia, one women in combination with headache, within 30 min after carbetocin administration.

Conclusion: Administration of the long-acting uterus stimulant carbetocin improved the MR-HIFU treatment intra-subject sonication efficiency in women with symptomatic uterine fibroids.

Original language	English
Article number	100413
Pages (from-to)	1-8
Journal	European journal of radiology open
Volume	9
DOIs	https://doi.org/10.1016/j.ejro.2022.100413
Publication status	Published - 1 Jan 2022

Keywords

Efficiency
High-intensity focused ultrasound ablation
MR guided interventional procedures
Myoma
Uterine fibroids
Uterus stimulant

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1-s2.0-S235204772200020XFinal published version, 1.94 MBLicence: CC BY-NC-ND

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Anneveldt, K. J., van 't Oever, H. J., Verpalen, I. M., Nijholt, I. M., Bartels, W., Dijkstra, J. R., van den Hoed, R. D., van 't Veer-Ten Kate, M., de Boer, E., Veersema, S., Huirne, J. A. F., Schutte, J. M., & Boomsma, M. F. (2022). Increased MR-guided high intensity focused ultrasound (MR-HIFU) sonication efficiency of uterine fibroids after carbetocin administration. European journal of radiology open, 9, 1-8. Article 100413. https://doi.org/10.1016/j.ejro.2022.100413

@article{1aa223cc16b343679e848c5d7219dea1,

title = "Increased MR-guided high intensity focused ultrasound (MR-HIFU) sonication efficiency of uterine fibroids after carbetocin administration",

abstract = "Purpose: We investigated whether administration of the long-acting uterus stimulant carbetocin increased intra-subject sonication efficiency during Magnetic Resonance image guided High Intensity Focused Ultrasound (MR-HIFU) treatment of uterine fibroids.Method: In this prospective cohort study, thirty women with symptomatic uterine fibroids undergoing MR-HIFU treatment were included between January 2018 and January 2019. Treatment started with three sonications on one side of the uterine fibroid. Subsequently, one ampoule of 1 mL carbetocin (100 µg/mL) was administered intravenously and treatment continued with three sonications on the other side of the uterine fibroid. We compared the intra-subject sonication efficiency, in terms of Energy Efficiency Factor (EEF), thermal dose volume and sonication time to ablate one cm 3 of fibroid tissue, before and after carbetocin administration. Adverse events that occurred within 30 min after carbetocin administration were recorded. Results: Sonication efficiency improved after carbetocin administration as indicated by a significant decrease in EEF and sonication time (p = 0.006 and p = 0.001 respectively), and a significant increase in thermal dose volume reached (p = <0.001). Five women (16.7\%) experienced temporary tachycardia, one women in combination with headache, within 30 min after carbetocin administration.Conclusion: Administration of the long-acting uterus stimulant carbetocin improved the MR-HIFU treatment intra-subject sonication efficiency in women with symptomatic uterine fibroids.",

keywords = "Efficiency, High-intensity focused ultrasound ablation, MR guided interventional procedures, Myoma, Uterine fibroids, Uterus stimulant",

author = "Anneveldt, \{Kimberley J\} and \{van 't Oever\}, \{Heleen J\} and Verpalen, \{Inez M\} and Nijholt, \{Ingrid M\} and Wilbert Bartels and Dijkstra, \{Jeroen R\} and \{van den Hoed\}, \{Rolf D\} and \{van 't Veer-Ten Kate\}, Miranda and \{de Boer\}, Erwin and Sebastiaan Veersema and Huirne, \{Judith A F\} and Schutte, \{Joke M\} and Boomsma, \{Martijn F\}",

note = "Funding Information: This research was made possible with financial support from the Innovation and Science fund of Isala Hospital Zwolle , the Netherlands. Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = jan,

day = "1",

doi = "10.1016/j.ejro.2022.100413",

language = "English",

volume = "9",

pages = "1--8",

journal = "European journal of radiology open",

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publisher = "Elsevier",

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Anneveldt, KJ, van 't Oever, HJ, Verpalen, IM, Nijholt, IM, Bartels, W, Dijkstra, JR, van den Hoed, RD, van 't Veer-Ten Kate, M, de Boer, E, Veersema, S, Huirne, JAF, Schutte, JM & Boomsma, MF 2022, 'Increased MR-guided high intensity focused ultrasound (MR-HIFU) sonication efficiency of uterine fibroids after carbetocin administration', European journal of radiology open, vol. 9, 100413, pp. 1-8. https://doi.org/10.1016/j.ejro.2022.100413

TY - JOUR

T1 - Increased MR-guided high intensity focused ultrasound (MR-HIFU) sonication efficiency of uterine fibroids after carbetocin administration

AU - Anneveldt, Kimberley J

AU - van 't Oever, Heleen J

AU - Verpalen, Inez M

AU - Nijholt, Ingrid M

AU - Bartels, Wilbert

AU - Dijkstra, Jeroen R

AU - van den Hoed, Rolf D

AU - van 't Veer-Ten Kate, Miranda

AU - de Boer, Erwin

AU - Veersema, Sebastiaan

AU - Huirne, Judith A F

AU - Schutte, Joke M

AU - Boomsma, Martijn F

N1 - Funding Information: This research was made possible with financial support from the Innovation and Science fund of Isala Hospital Zwolle , the Netherlands. Publisher Copyright: © 2022 The Authors

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Purpose: We investigated whether administration of the long-acting uterus stimulant carbetocin increased intra-subject sonication efficiency during Magnetic Resonance image guided High Intensity Focused Ultrasound (MR-HIFU) treatment of uterine fibroids.Method: In this prospective cohort study, thirty women with symptomatic uterine fibroids undergoing MR-HIFU treatment were included between January 2018 and January 2019. Treatment started with three sonications on one side of the uterine fibroid. Subsequently, one ampoule of 1 mL carbetocin (100 µg/mL) was administered intravenously and treatment continued with three sonications on the other side of the uterine fibroid. We compared the intra-subject sonication efficiency, in terms of Energy Efficiency Factor (EEF), thermal dose volume and sonication time to ablate one cm 3 of fibroid tissue, before and after carbetocin administration. Adverse events that occurred within 30 min after carbetocin administration were recorded. Results: Sonication efficiency improved after carbetocin administration as indicated by a significant decrease in EEF and sonication time (p = 0.006 and p = 0.001 respectively), and a significant increase in thermal dose volume reached (p = <0.001). Five women (16.7%) experienced temporary tachycardia, one women in combination with headache, within 30 min after carbetocin administration.Conclusion: Administration of the long-acting uterus stimulant carbetocin improved the MR-HIFU treatment intra-subject sonication efficiency in women with symptomatic uterine fibroids.

AB - Purpose: We investigated whether administration of the long-acting uterus stimulant carbetocin increased intra-subject sonication efficiency during Magnetic Resonance image guided High Intensity Focused Ultrasound (MR-HIFU) treatment of uterine fibroids.Method: In this prospective cohort study, thirty women with symptomatic uterine fibroids undergoing MR-HIFU treatment were included between January 2018 and January 2019. Treatment started with three sonications on one side of the uterine fibroid. Subsequently, one ampoule of 1 mL carbetocin (100 µg/mL) was administered intravenously and treatment continued with three sonications on the other side of the uterine fibroid. We compared the intra-subject sonication efficiency, in terms of Energy Efficiency Factor (EEF), thermal dose volume and sonication time to ablate one cm 3 of fibroid tissue, before and after carbetocin administration. Adverse events that occurred within 30 min after carbetocin administration were recorded. Results: Sonication efficiency improved after carbetocin administration as indicated by a significant decrease in EEF and sonication time (p = 0.006 and p = 0.001 respectively), and a significant increase in thermal dose volume reached (p = <0.001). Five women (16.7%) experienced temporary tachycardia, one women in combination with headache, within 30 min after carbetocin administration.Conclusion: Administration of the long-acting uterus stimulant carbetocin improved the MR-HIFU treatment intra-subject sonication efficiency in women with symptomatic uterine fibroids.

KW - Efficiency

KW - High-intensity focused ultrasound ablation

KW - MR guided interventional procedures

KW - Myoma

KW - Uterine fibroids

KW - Uterus stimulant

UR - https://www.scopus.com/pages/publications/85126648561

U2 - 10.1016/j.ejro.2022.100413

DO - 10.1016/j.ejro.2022.100413

M3 - Article

C2 - 35340827

SN - 2352-0477

VL - 9

SP - 1

EP - 8

JO - European journal of radiology open

JF - European journal of radiology open

M1 - 100413

ER -

Increased MR-guided high intensity focused ultrasound (MR-HIFU) sonication efficiency of uterine fibroids after carbetocin administration

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