Increased frequency of HLA-DRB1*15 in patients with multifocal motor neuropathy

N.A. Sutedja; H.G. Otten; E.A. Cats; S. Piepers; J.H. Veldink; W.L. van der Pol; L.H. van den Berg

doi:10.1212/WNL.0b013e3181d3e2f6

Increased frequency of HLA-DRB1*15 in patients with multifocal motor neuropathy

N.A. Sutedja, H.G. Otten, E.A. Cats, S. Piepers, J.H. Veldink, W.L. van der Pol, L.H. van den Berg

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVES: The favorable response to treatment with IV immunoglobulins and the presence of IgM antibodies to the glycolipid GM1 are indications that inflammation underlies multifocal motor neuropathy (MMN) pathogenesis. We investigated the association of MMN with human leukocyte antigen (HLA) class I and II antigens.

METHODS: HLA class I and II antigens of 74 Dutch patients with MMN and 700 controls were determined in a case-control study. Associations of HLA types with MMN disease characteristics were investigated.

RESULTS: Compared with controls, patients with MMN had higher frequencies of HLA-DRB1*15 (41 vs 24%, p = 0.0017). Disease characteristics were not associated with specific HLA types.

CONCLUSIONS: Similar associations were found in patients with multiple sclerosis and women with chronic immune-mediated demyelinating neuropathy, which may suggest that these demyelinating disorders share pathogenic mechanisms.

Original language	English
Pages (from-to)	828-832
Number of pages	5
Journal	Neurology
Volume	74
Issue number	10
DOIs	https://doi.org/10.1212/WNL.0b013e3181d3e2f6
Publication status	Published - 2010

Keywords

Adult
Age Factors
Aged
Brachial Plexus
Case-Control Studies
Chi-Square Distribution
Female
G(M1) Ganglioside
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DR Antigens
HLA-DRB1 Chains
Humans
Immunoglobulin M
Magnetic Resonance Imaging
Male
Membrane Glycoproteins
Middle Aged
Multiple Sclerosis
Neural Conduction
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Retrospective Studies
Journal Article
Research Support, Non-U.S. Gov't

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10.1212/WNL.0b013e3181d3e2f6

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@article{1784c8bb78b44633813380d66ff4b600,

title = "Increased frequency of HLA-DRB1*15 in patients with multifocal motor neuropathy",

abstract = "OBJECTIVES: The favorable response to treatment with IV immunoglobulins and the presence of IgM antibodies to the glycolipid GM1 are indications that inflammation underlies multifocal motor neuropathy (MMN) pathogenesis. We investigated the association of MMN with human leukocyte antigen (HLA) class I and II antigens.METHODS: HLA class I and II antigens of 74 Dutch patients with MMN and 700 controls were determined in a case-control study. Associations of HLA types with MMN disease characteristics were investigated.RESULTS: Compared with controls, patients with MMN had higher frequencies of HLA-DRB1*15 (41 vs 24%, p = 0.0017). Disease characteristics were not associated with specific HLA types.CONCLUSIONS: Similar associations were found in patients with multiple sclerosis and women with chronic immune-mediated demyelinating neuropathy, which may suggest that these demyelinating disorders share pathogenic mechanisms.",

keywords = "Adult, Age Factors, Aged, Brachial Plexus, Case-Control Studies, Chi-Square Distribution, Female, G(M1) Ganglioside, HLA-DQ Antigens, HLA-DQ beta-Chains, HLA-DR Antigens, HLA-DRB1 Chains, Humans, Immunoglobulin M, Magnetic Resonance Imaging, Male, Membrane Glycoproteins, Middle Aged, Multiple Sclerosis, Neural Conduction, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Retrospective Studies, Journal Article, Research Support, Non-U.S. Gov't",

author = "N.A. Sutedja and H.G. Otten and E.A. Cats and S. Piepers and J.H. Veldink and {van der Pol}, W.L. and {van den Berg}, L.H.",

year = "2010",

doi = "10.1212/WNL.0b013e3181d3e2f6",

language = "English",

volume = "74",

pages = "828--832",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams & Wilkins",

number = "10",

}

TY - JOUR

T1 - Increased frequency of HLA-DRB1*15 in patients with multifocal motor neuropathy

AU - Sutedja, N.A.

AU - Otten, H.G.

AU - Cats, E.A.

AU - Piepers, S.

AU - Veldink, J.H.

AU - van der Pol, W.L.

AU - van den Berg, L.H.

PY - 2010

Y1 - 2010

N2 - OBJECTIVES: The favorable response to treatment with IV immunoglobulins and the presence of IgM antibodies to the glycolipid GM1 are indications that inflammation underlies multifocal motor neuropathy (MMN) pathogenesis. We investigated the association of MMN with human leukocyte antigen (HLA) class I and II antigens.METHODS: HLA class I and II antigens of 74 Dutch patients with MMN and 700 controls were determined in a case-control study. Associations of HLA types with MMN disease characteristics were investigated.RESULTS: Compared with controls, patients with MMN had higher frequencies of HLA-DRB1*15 (41 vs 24%, p = 0.0017). Disease characteristics were not associated with specific HLA types.CONCLUSIONS: Similar associations were found in patients with multiple sclerosis and women with chronic immune-mediated demyelinating neuropathy, which may suggest that these demyelinating disorders share pathogenic mechanisms.

AB - OBJECTIVES: The favorable response to treatment with IV immunoglobulins and the presence of IgM antibodies to the glycolipid GM1 are indications that inflammation underlies multifocal motor neuropathy (MMN) pathogenesis. We investigated the association of MMN with human leukocyte antigen (HLA) class I and II antigens.METHODS: HLA class I and II antigens of 74 Dutch patients with MMN and 700 controls were determined in a case-control study. Associations of HLA types with MMN disease characteristics were investigated.RESULTS: Compared with controls, patients with MMN had higher frequencies of HLA-DRB1*15 (41 vs 24%, p = 0.0017). Disease characteristics were not associated with specific HLA types.CONCLUSIONS: Similar associations were found in patients with multiple sclerosis and women with chronic immune-mediated demyelinating neuropathy, which may suggest that these demyelinating disorders share pathogenic mechanisms.

KW - Adult

KW - Age Factors

KW - Aged

KW - Brachial Plexus

KW - Case-Control Studies

KW - Chi-Square Distribution

KW - Female

KW - G(M1) Ganglioside

KW - HLA-DQ Antigens

KW - HLA-DQ beta-Chains

KW - HLA-DR Antigens

KW - HLA-DRB1 Chains

KW - Humans

KW - Immunoglobulin M

KW - Magnetic Resonance Imaging

KW - Male

KW - Membrane Glycoproteins

KW - Middle Aged

KW - Multiple Sclerosis

KW - Neural Conduction

KW - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

KW - Retrospective Studies

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1212/WNL.0b013e3181d3e2f6

DO - 10.1212/WNL.0b013e3181d3e2f6

M3 - Article

C2 - 20211906

SN - 0028-3878

VL - 74

SP - 828

EP - 832

JO - Neurology

JF - Neurology

IS - 10

ER -

Increased frequency of HLA-DRB1*15 in patients with multifocal motor neuropathy

Abstract

Keywords

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