Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

M.D. Hazenberg; S.A. Otto; J.W.T. Cohen Stuart; M.C. Verschuren; J.C.C. Borleffs; C.A.B. Boucher; R.A. Coutinho; T.F. Rinke de Wit; A. Tsegaye; J.M. van Dongen; D. Hamann; R.J. de Boer; F. Miedema

doi:10.1038/79549

Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

M.D. Hazenberg, S.A. Otto, J.W.T. Cohen Stuart, M.C. Verschuren, J.C.C. Borleffs, C.A.B. Boucher, R.A. Coutinho, T.F. Rinke de Wit, A. Tsegaye, J.M. van Dongen, D. Hamann, R.J. de Boer, F. Miedema

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show that in healthy individuals, declining thymic output will affect the TREC content only when accompanied by naive T-cell division. The rapid decline in TRECs observed during HIV-1 infection and the increase following HAART are better explained not by thymic impairment, but by changes in peripheral T-cell division rates. Our data indicate that TREC content in healthy individuals is only indirectly related to thymic output, and in HIV-1 infection is mainly affected by immune activation.

Original language	English
Pages (from-to)	1036-1042
Number of pages	7
Journal	Nature Medicine
Volume	6
Issue number	9
DOIs	https://doi.org/10.1038/79549
Publication status	Published - Sept 2000

Keywords

Life sciences
Biologie/Milieukunde (BIOL)
Biomathematics and biometrics

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10.1038/79549

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Hazenberg, M. D., Otto, S. A., Cohen Stuart, J. W. T., Verschuren, M. C., Borleffs, J. C. C., Boucher, C. A. B., Coutinho, R. A., Rinke de Wit, T. F., Tsegaye, A., van Dongen, J. M., Hamann, D., de Boer, R. J., & Miedema, F. (2000). Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nature Medicine, 6(9), 1036-1042. https://doi.org/10.1038/79549

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title = "Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection",

abstract = "Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show that in healthy individuals, declining thymic output will affect the TREC content only when accompanied by naive T-cell division. The rapid decline in TRECs observed during HIV-1 infection and the increase following HAART are better explained not by thymic impairment, but by changes in peripheral T-cell division rates. Our data indicate that TREC content in healthy individuals is only indirectly related to thymic output, and in HIV-1 infection is mainly affected by immune activation.",

keywords = "Life sciences, Biologie/Milieukunde (BIOL), Biomathematics and biometrics",

author = "M.D. Hazenberg and S.A. Otto and {Cohen Stuart}, J.W.T. and M.C. Verschuren and J.C.C. Borleffs and C.A.B. Boucher and R.A. Coutinho and {Rinke de Wit}, T.F. and A. Tsegaye and {van Dongen}, J.M. and D. Hamann and {de Boer}, R.J. and F. Miedema",

year = "2000",

month = sep,

doi = "10.1038/79549",

language = "English",

volume = "6",

pages = "1036--1042",

journal = "Nature Medicine",

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Hazenberg, MD, Otto, SA, Cohen Stuart, JWT, Verschuren, MC, Borleffs, JCC, Boucher, CAB, Coutinho, RA, Rinke de Wit, TF, Tsegaye, A, van Dongen, JM, Hamann, D, de Boer, RJ & Miedema, F 2000, 'Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection', Nature Medicine, vol. 6, no. 9, pp. 1036-1042. https://doi.org/10.1038/79549

TY - JOUR

T1 - Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

AU - Hazenberg, M.D.

AU - Otto, S.A.

AU - Cohen Stuart, J.W.T.

AU - Verschuren, M.C.

AU - Borleffs, J.C.C.

AU - Boucher, C.A.B.

AU - Coutinho, R.A.

AU - Rinke de Wit, T.F.

AU - Tsegaye, A.

AU - van Dongen, J.M.

AU - Hamann, D.

AU - de Boer, R.J.

AU - Miedema, F.

PY - 2000/9

Y1 - 2000/9

N2 - Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show that in healthy individuals, declining thymic output will affect the TREC content only when accompanied by naive T-cell division. The rapid decline in TRECs observed during HIV-1 infection and the increase following HAART are better explained not by thymic impairment, but by changes in peripheral T-cell division rates. Our data indicate that TREC content in healthy individuals is only indirectly related to thymic output, and in HIV-1 infection is mainly affected by immune activation.

AB - Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show that in healthy individuals, declining thymic output will affect the TREC content only when accompanied by naive T-cell division. The rapid decline in TRECs observed during HIV-1 infection and the increase following HAART are better explained not by thymic impairment, but by changes in peripheral T-cell division rates. Our data indicate that TREC content in healthy individuals is only indirectly related to thymic output, and in HIV-1 infection is mainly affected by immune activation.

KW - Life sciences

KW - Biologie/Milieukunde (BIOL)

KW - Biomathematics and biometrics

U2 - 10.1038/79549

DO - 10.1038/79549

M3 - Article

C2 - 10973325

SN - 1078-8956

VL - 6

SP - 1036

EP - 1042

JO - Nature Medicine

JF - Nature Medicine

IS - 9

ER -

Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

Abstract

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