Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever

Tom Versteege; Mulya R. Karyanti; Witri Septiani; Annisa L. Widjanarko; Nikmah S. Idris; Aryono Hendarto; Diederick E. Grobbee; David Burgner; Cuno S.P.M. Uiterwaal; Patricia C.J.L. Bruijning-Verhagen

doi:10.4269/ajtmh.18-0672

Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever

Tom Versteege^*, Mulya R. Karyanti, Witri Septiani, Annisa L. Widjanarko, Nikmah S. Idris, Aryono Hendarto, Diederick E. Grobbee, David Burgner, Cuno S.P.M. Uiterwaal, Patricia C.J.L. Bruijning-Verhagen

^*Corresponding author for this work

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Abstract

We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 µm (95% confidence interval [CI]: 10.0-75.3, P = 0.01), and 61.7 µm (95% CI: 21.5-102.0, P < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity.

Original language	English
Pages (from-to)	630-634
Number of pages	5
Journal	American Journal of Tropical Medicine and Hygiene
Volume	100
Issue number	3
DOIs	https://doi.org/10.4269/ajtmh.18-0672
Publication status	Published - Mar 2019

Keywords

Adolescent
Adult
Carotid Intima-Media Thickness
Child
Child, Preschool
Female
Humans
Male
Severe Dengue/complications
Young Adult

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Versteege, T., Karyanti, M. R., Septiani, W., Widjanarko, A. L., Idris, N. S., Hendarto, A., Grobbee, D. E., Burgner, D., Uiterwaal, C. S. P. M., & Bruijning-Verhagen, P. C. J. L. (2019). Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever. American Journal of Tropical Medicine and Hygiene, 100(3), 630-634. https://doi.org/10.4269/ajtmh.18-0672

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title = "Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever",

abstract = "We assessed carotid intima-media thickness (cIMT) and arterial stiffness in 28 children and adolescents with previous dengue hemorrhagic fever (DHF) (mean interval between DHF and cardiovascular assessment, 8.4 years), and 34 controls in a low-resource setting. Participants with previous DHF had an adjusted increased cIMT of 42.6 µm (95% confidence interval [CI]: 10.0-75.3, P = 0.01), and 61.7 µm (95% CI: 21.5-102.0, P < 0.01) in a subgroup analysis on dengue shock syndrome. There were no differences in arterial stiffness. In this first exploratory study, children and adolescents with a history of DHF had an increased cIMT, which may be modulated by dengue severity. ",

keywords = "Adolescent, Adult, Carotid Intima-Media Thickness, Child, Child, Preschool, Female, Humans, Male, Severe Dengue/complications, Young Adult",

author = "Tom Versteege and Karyanti, {Mulya R.} and Witri Septiani and Widjanarko, {Annisa L.} and Idris, {Nikmah S.} and Aryono Hendarto and Grobbee, {Diederick E.} and David Burgner and Uiterwaal, {Cuno S.P.M.} and Bruijning-Verhagen, {Patricia C.J.L.}",

year = "2019",

month = mar,

doi = "10.4269/ajtmh.18-0672",

language = "English",

volume = "100",

pages = "630--634",

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Versteege, T, Karyanti, MR, Septiani, W, Widjanarko, AL, Idris, NS, Hendarto, A, Grobbee, DE, Burgner, D, Uiterwaal, CSPM & Bruijning-Verhagen, PCJL 2019, 'Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever', American Journal of Tropical Medicine and Hygiene, vol. 100, no. 3, pp. 630-634. https://doi.org/10.4269/ajtmh.18-0672

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AU - Karyanti, Mulya R.

AU - Septiani, Witri

AU - Widjanarko, Annisa L.

AU - Idris, Nikmah S.

AU - Hendarto, Aryono

AU - Grobbee, Diederick E.

AU - Burgner, David

AU - Uiterwaal, Cuno S.P.M.

AU - Bruijning-Verhagen, Patricia C.J.L.

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KW - Adult

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KW - Child, Preschool

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ER -

Increased carotid intima-media thickness in children with a history of dengue hemorrhagic fever

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Keywords

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