Incidence of retinoblastoma in children born after in-vitro fertilisation

Annette C. Moll; Saskia M. Imhof; Johannes R.M. Cruysberg; Antoinette Y.N. Schouten-van Meeteren; Maarten Boers; Flora E. Van Leeuwen

doi:10.1016/S0140-6736(03)12332-X

Incidence of retinoblastoma in children born after in-vitro fertilisation

Annette C. Moll^*, Saskia M. Imhof, Johannes R.M. Cruysberg, Antoinette Y.N. Schouten-van Meeteren, Maarten Boers, Flora E. Van Leeuwen

^*Corresponding author for this work

Infection & Immunity

Research output: Contribution to journal › Article › Academic › peer-review

250 Citations (Scopus)

Abstract

Every year, 3000 women in the Netherlands are treated with in-vitro fertilisation (IVF), and results from studies suggest that the offspring of these women do not have a heightened risk of cancer. Between November, 2000, and February, 2002, we diagnosed retinoblastoma in five patients born after IVF. To calculate the relative risk of the disease, we assumed that the proportion of children conceived by IVF in the Netherlands is between 1·0 and 1·5%, and that the five patients who we diagnosed with the disease represent all new cases in the Netherlands during that period. Relative risks for retinoblastoma were significantly raised (7·2 [95% CI 2·4-17·0], and 4·9 [1·6-11·3], for 1% and 1·5% rates, respectively). This possible association of an increased risk of retinoblastoma in a population-based study needs to be established.

Original language	English
Pages (from-to)	309-310
Number of pages	2
Journal	Lancet
Volume	361
Issue number	9354
DOIs	https://doi.org/10.1016/S0140-6736(03)12332-X
Publication status	Published - 25 Jan 2003

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title = "Incidence of retinoblastoma in children born after in-vitro fertilisation",

abstract = "Every year, 3000 women in the Netherlands are treated with in-vitro fertilisation (IVF), and results from studies suggest that the offspring of these women do not have a heightened risk of cancer. Between November, 2000, and February, 2002, we diagnosed retinoblastoma in five patients born after IVF. To calculate the relative risk of the disease, we assumed that the proportion of children conceived by IVF in the Netherlands is between 1·0 and 1·5%, and that the five patients who we diagnosed with the disease represent all new cases in the Netherlands during that period. Relative risks for retinoblastoma were significantly raised (7·2 [95% CI 2·4-17·0], and 4·9 [1·6-11·3], for 1% and 1·5% rates, respectively). This possible association of an increased risk of retinoblastoma in a population-based study needs to be established.",

author = "Moll, {Annette C.} and Imhof, {Saskia M.} and Cruysberg, {Johannes R.M.} and {Schouten-van Meeteren}, {Antoinette Y.N.} and Maarten Boers and {Van Leeuwen}, {Flora E.}",

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TY - JOUR

T1 - Incidence of retinoblastoma in children born after in-vitro fertilisation

AU - Moll, Annette C.

AU - Imhof, Saskia M.

AU - Cruysberg, Johannes R.M.

AU - Schouten-van Meeteren, Antoinette Y.N.

AU - Boers, Maarten

AU - Van Leeuwen, Flora E.

PY - 2003/1/25

Y1 - 2003/1/25

N2 - Every year, 3000 women in the Netherlands are treated with in-vitro fertilisation (IVF), and results from studies suggest that the offspring of these women do not have a heightened risk of cancer. Between November, 2000, and February, 2002, we diagnosed retinoblastoma in five patients born after IVF. To calculate the relative risk of the disease, we assumed that the proportion of children conceived by IVF in the Netherlands is between 1·0 and 1·5%, and that the five patients who we diagnosed with the disease represent all new cases in the Netherlands during that period. Relative risks for retinoblastoma were significantly raised (7·2 [95% CI 2·4-17·0], and 4·9 [1·6-11·3], for 1% and 1·5% rates, respectively). This possible association of an increased risk of retinoblastoma in a population-based study needs to be established.

AB - Every year, 3000 women in the Netherlands are treated with in-vitro fertilisation (IVF), and results from studies suggest that the offspring of these women do not have a heightened risk of cancer. Between November, 2000, and February, 2002, we diagnosed retinoblastoma in five patients born after IVF. To calculate the relative risk of the disease, we assumed that the proportion of children conceived by IVF in the Netherlands is between 1·0 and 1·5%, and that the five patients who we diagnosed with the disease represent all new cases in the Netherlands during that period. Relative risks for retinoblastoma were significantly raised (7·2 [95% CI 2·4-17·0], and 4·9 [1·6-11·3], for 1% and 1·5% rates, respectively). This possible association of an increased risk of retinoblastoma in a population-based study needs to be established.

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U2 - 10.1016/S0140-6736(03)12332-X

DO - 10.1016/S0140-6736(03)12332-X

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SN - 0140-6736

VL - 361

SP - 309

EP - 310

JO - Lancet

JF - Lancet

IS - 9354

ER -

Incidence of retinoblastoma in children born after in-vitro fertilisation

Abstract

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