In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors

Lynn Yap; Jiong Wei Wang; Aida Moreno-Moral; Li Yen Chong; Yi Sun; Nathan Harmston; Xiaoyuan Wang; Suet Yen Chong; Miina K. Öhman; Heming Wei; Ralph Bunte; Sujoy Gosh; Stuart Cook; Outi Hovatta; Dominique P.V. de Kleijn; Enrico Petretto; Karl Tryggvason

doi:10.1016/j.celrep.2019.02.083

In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors

Lynn Yap, Jiong Wei Wang, Aida Moreno-Moral, Li Yen Chong, Yi Sun, Nathan Harmston, Xiaoyuan Wang, Suet Yen Chong, Miina K. Öhman, Heming Wei, Ralph Bunte, Sujoy Gosh, Stuart Cook, Outi Hovatta, Dominique P.V. de Kleijn, Enrico Petretto, Karl Tryggvason^*

^*Corresponding author for this work

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Abstract

Yap et al. perform in vitro differentiation of pluripotent embryonic stem cells to cardiovascular progenitors using laminin-221 as a culture matrix in a fully human and chemically defined protocol. Use of these cells for in vivo cardiac regeneration and to generate human heart muscle bundles results in improved heart function.

Original language	English
Pages (from-to)	3231-3245.e9
Journal	Cell Reports
Volume	26
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2019.02.083
Publication status	Published - 19 Mar 2019

Keywords

cardiovascular progenitors
hESC-based cardiac muscle regeneration
laminin
regenerative cardiology

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10.1016/j.celrep.2019.02.083Licence: CC BY

1-s2.0-S2211124719302694-mainextFinal published version, 14.6 MBLicence: CC BY

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Yap, L., Wang, J. W., Moreno-Moral, A., Chong, L. Y., Sun, Y., Harmston, N., Wang, X., Chong, S. Y., Öhman, M. K., Wei, H., Bunte, R., Gosh, S., Cook, S., Hovatta, O., de Kleijn, D. P. V., Petretto, E., & Tryggvason, K. (2019). In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors. Cell Reports, 26(12), 3231-3245.e9. https://doi.org/10.1016/j.celrep.2019.02.083

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abstract = "Yap et al. perform in vitro differentiation of pluripotent embryonic stem cells to cardiovascular progenitors using laminin-221 as a culture matrix in a fully human and chemically defined protocol. Use of these cells for in vivo cardiac regeneration and to generate human heart muscle bundles results in improved heart function.",

keywords = "cardiovascular progenitors, hESC-based cardiac muscle regeneration, laminin, regenerative cardiology",

author = "Lynn Yap and Wang, {Jiong Wei} and Aida Moreno-Moral and Chong, {Li Yen} and Yi Sun and Nathan Harmston and Xiaoyuan Wang and Chong, {Suet Yen} and {\"O}hman, {Miina K.} and Heming Wei and Ralph Bunte and Sujoy Gosh and Stuart Cook and Outi Hovatta and {de Kleijn}, {Dominique P.V.} and Enrico Petretto and Karl Tryggvason",

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doi = "10.1016/j.celrep.2019.02.083",

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Yap, L, Wang, JW, Moreno-Moral, A, Chong, LY, Sun, Y, Harmston, N, Wang, X, Chong, SY, Öhman, MK, Wei, H, Bunte, R, Gosh, S, Cook, S, Hovatta, O, de Kleijn, DPV, Petretto, E & Tryggvason, K 2019, 'In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors', Cell Reports, vol. 26, no. 12, pp. 3231-3245.e9. https://doi.org/10.1016/j.celrep.2019.02.083

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AU - Yap, Lynn

AU - Wang, Jiong Wei

AU - Moreno-Moral, Aida

AU - Chong, Li Yen

AU - Sun, Yi

AU - Harmston, Nathan

AU - Wang, Xiaoyuan

AU - Chong, Suet Yen

AU - Öhman, Miina K.

AU - Wei, Heming

AU - Bunte, Ralph

AU - Gosh, Sujoy

AU - Cook, Stuart

AU - Hovatta, Outi

AU - de Kleijn, Dominique P.V.

AU - Petretto, Enrico

AU - Tryggvason, Karl

PY - 2019/3/19

Y1 - 2019/3/19

N2 - Yap et al. perform in vitro differentiation of pluripotent embryonic stem cells to cardiovascular progenitors using laminin-221 as a culture matrix in a fully human and chemically defined protocol. Use of these cells for in vivo cardiac regeneration and to generate human heart muscle bundles results in improved heart function.

AB - Yap et al. perform in vitro differentiation of pluripotent embryonic stem cells to cardiovascular progenitors using laminin-221 as a culture matrix in a fully human and chemically defined protocol. Use of these cells for in vivo cardiac regeneration and to generate human heart muscle bundles results in improved heart function.

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KW - hESC-based cardiac muscle regeneration

KW - laminin

KW - regenerative cardiology

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SN - 2211-1247

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SP - 3231-3245.e9

JO - Cell Reports

JF - Cell Reports

IS - 12

ER -

In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors

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Keywords

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Erratum: In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors (Cell Reports (2019) 26(12) (3231–3245.e9), (S2211124719302694), (10.1016/j.celrep.2019.02.083))

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