In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow

Mariona Baliu-Piqué; Sigrid A. Otto; José A.M. Borghans; Kiki Tesselaar

doi:10.1016/j.imlet.2019.04.004

In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow

Mariona Baliu-Piqué
, Sigrid A. Otto
, José A.M. Borghans
, Kiki Tesselaar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

1 Downloads (Pure)

Abstract

The maintenance and dynamics of memory T-cells in the bone marrow are a matter of ongoing debate. It has been suggested that memory T-cells in the bone marrow are maintained as long-lived, quiescent cells. We have recently shown that memory T-cells isolated from goat bone marrow undergo self-renewal and recirculate via the blood and lymph. Using the well-established memory T-cell markers CD44 and CD62L we here show very similar results in mice. This provides further support for the concept that memory T-cells are continuously self-renewing and recirculating between blood, bone marrow, spleen and lymph nodes.

Original language	English
Pages (from-to)	29-32
Number of pages	4
Journal	Immunology Letters
Volume	210
DOIs	https://doi.org/10.1016/j.imlet.2019.04.004
Publication status	Published - Jun 2019

Keywords

Bone marrow
Deuterium
Lymphocyte turnover
Mathematical modelling
Memory T-cells
Stable isotope labelling

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10.1016/j.imlet.2019.04.004

baliu-piqueFinal published version, 1.87 MBLicence: Taverne

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title = "In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow",

abstract = "The maintenance and dynamics of memory T-cells in the bone marrow are a matter of ongoing debate. It has been suggested that memory T-cells in the bone marrow are maintained as long-lived, quiescent cells. We have recently shown that memory T-cells isolated from goat bone marrow undergo self-renewal and recirculate via the blood and lymph. Using the well-established memory T-cell markers CD44 and CD62L we here show very similar results in mice. This provides further support for the concept that memory T-cells are continuously self-renewing and recirculating between blood, bone marrow, spleen and lymph nodes.",

keywords = "Bone marrow, Deuterium, Lymphocyte turnover, Mathematical modelling, Memory T-cells, Stable isotope labelling",

author = "Mariona Baliu-Piqu{\'e} and Otto, \{Sigrid A.\} and Borghans, \{Jos{\'e} A.M.\} and Kiki Tesselaar",

note = "Funding Information: The research leading to these results has received funding from the European Union Seventh Framework Programme ( FP7/2007–2013 ) through the Marie-Curie Action “Quantitative T cell Immunology” Initial Training Network, with reference number FP7-PEOPLE-2012-ITN 317040-QuanTI. Funding Information: The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007–2013) through the Marie-Curie Action “Quantitative T cell Immunology” Initial Training Network, with reference number FP7-PEOPLE-2012-ITN 317040-QuanTI. We thank Julia Drylewicz for theoretical and technical input, Nienke Vrisekoop for help and support with the animal experiments, and Derek C. Macallan and Linda Hadcocks for measuring 2H2O enrichment in body water. Publisher Copyright: {\textcopyright} 2019 European Federation of Immunological Societies",

year = "2019",

month = jun,

doi = "10.1016/j.imlet.2019.04.004",

language = "English",

volume = "210",

pages = "29--32",

journal = "Immunology Letters",

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AU - Baliu-Piqué, Mariona

AU - Otto, Sigrid A.

AU - Borghans, José A.M.

AU - Tesselaar, Kiki

N1 - Funding Information: The research leading to these results has received funding from the European Union Seventh Framework Programme ( FP7/2007–2013 ) through the Marie-Curie Action “Quantitative T cell Immunology” Initial Training Network, with reference number FP7-PEOPLE-2012-ITN 317040-QuanTI. Funding Information: The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007–2013) through the Marie-Curie Action “Quantitative T cell Immunology” Initial Training Network, with reference number FP7-PEOPLE-2012-ITN 317040-QuanTI. We thank Julia Drylewicz for theoretical and technical input, Nienke Vrisekoop for help and support with the animal experiments, and Derek C. Macallan and Linda Hadcocks for measuring 2H2O enrichment in body water. Publisher Copyright: © 2019 European Federation of Immunological Societies

PY - 2019/6

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N2 - The maintenance and dynamics of memory T-cells in the bone marrow are a matter of ongoing debate. It has been suggested that memory T-cells in the bone marrow are maintained as long-lived, quiescent cells. We have recently shown that memory T-cells isolated from goat bone marrow undergo self-renewal and recirculate via the blood and lymph. Using the well-established memory T-cell markers CD44 and CD62L we here show very similar results in mice. This provides further support for the concept that memory T-cells are continuously self-renewing and recirculating between blood, bone marrow, spleen and lymph nodes.

AB - The maintenance and dynamics of memory T-cells in the bone marrow are a matter of ongoing debate. It has been suggested that memory T-cells in the bone marrow are maintained as long-lived, quiescent cells. We have recently shown that memory T-cells isolated from goat bone marrow undergo self-renewal and recirculate via the blood and lymph. Using the well-established memory T-cell markers CD44 and CD62L we here show very similar results in mice. This provides further support for the concept that memory T-cells are continuously self-renewing and recirculating between blood, bone marrow, spleen and lymph nodes.

KW - Bone marrow

KW - Deuterium

KW - Lymphocyte turnover

KW - Mathematical modelling

KW - Memory T-cells

KW - Stable isotope labelling

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DO - 10.1016/j.imlet.2019.04.004

M3 - Article

C2 - 31004681

SN - 0165-2478

VL - 210

SP - 29

EP - 32

JO - Immunology Letters

JF - Immunology Letters

ER -

In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow

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Keywords

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