@article{290abcace7864bc791355f631ce64a67,
title = "In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow",
abstract = "The maintenance and dynamics of memory T-cells in the bone marrow are a matter of ongoing debate. It has been suggested that memory T-cells in the bone marrow are maintained as long-lived, quiescent cells. We have recently shown that memory T-cells isolated from goat bone marrow undergo self-renewal and recirculate via the blood and lymph. Using the well-established memory T-cell markers CD44 and CD62L we here show very similar results in mice. This provides further support for the concept that memory T-cells are continuously self-renewing and recirculating between blood, bone marrow, spleen and lymph nodes.",
keywords = "Bone marrow, Deuterium, Lymphocyte turnover, Mathematical modelling, Memory T-cells, Stable isotope labelling",
author = "Mariona Baliu-Piqu{\'e} and Otto, {Sigrid A.} and Borghans, {Jos{\'e} A.M.} and Kiki Tesselaar",
note = "Funding Information: The research leading to these results has received funding from the European Union Seventh Framework Programme ( FP7/2007–2013 ) through the Marie-Curie Action “Quantitative T cell Immunology” Initial Training Network, with reference number FP7-PEOPLE-2012-ITN 317040-QuanTI. Funding Information: The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007–2013) through the Marie-Curie Action “Quantitative T cell Immunology” Initial Training Network, with reference number FP7-PEOPLE-2012-ITN 317040-QuanTI. We thank Julia Drylewicz for theoretical and technical input, Nienke Vrisekoop for help and support with the animal experiments, and Derek C. Macallan and Linda Hadcocks for measuring 2H2O enrichment in body water. Publisher Copyright: {\textcopyright} 2019 European Federation of Immunological Societies",
year = "2019",
month = jun,
doi = "10.1016/j.imlet.2019.04.004",
language = "English",
volume = "210",
pages = "29--32",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier",
}