Abstract
Cryptococcus neoformans is the leading cause of cryptococcosis in HIV-infected subjects worldwide. Treatment of cryptococcosis is based on amphotericin B, flucytosine, and fluconazole. In Zimbabwe, little is known about antifungal susceptibility of Cryptococcus. Sixty-eight genotyped Cryptococcus isolates were tested for antifungal profiles. Amphotericin B, isavuconazole, and voriconazole showed higher activity than other triazoles. Fluconazole and flucytosine were less effective, with geometric mean MICs of 2.24 and 2.67mg/L for C. neoformans AFLP1/VNI, 1.38 and 1.53mg/L for C. neoformans AFLP1A/VNB/VNII and AFLP1B/VNII, and 1.85 and 0.68mg/L for Cryptococcus tetragattii, respectively. A significant difference between flucytosine geometric mean MICs of C. neoformans and C. tetragattii was observed (P=0.0002). The majority of isolates (n=66/68; 97.1%) had a wild-type MIC phenotype of all antifungal agents. This study demonstrates a favorable situation with respect to the tested antifungals agents. Continued surveillance of antifungal susceptibility profiles is important due to the high burden of cryptococcosis in Africa.
| Original language | English |
|---|---|
| Pages (from-to) | 289-292 |
| Number of pages | 4 |
| Journal | Diagnostic Microbiology and Infectious Disease |
| Volume | 86 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Nov 2016 |
| Externally published | Yes |
Keywords
- Adolescent
- Adult
- Antifungal Agents/pharmacology
- Cohort Studies
- Cryptococcus neoformans/drug effects
- Female
- HIV Infections/complications
- Humans
- Male
- Meningitis, Cryptococcal/microbiology
- Microbial Sensitivity Tests
- Middle Aged
- Young Adult
- Zimbabwe
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