In vitro antibacterial activity of sucralfate

D Bergmans; M. Bonten; C. Gaillard; F. van Tiel; S. de Geest; Ellen E Stobberingh

doi:10.1007/BF01971318

In vitro antibacterial activity of sucralfate

D Bergmans, M. Bonten^*, C. Gaillard, F. van Tiel, S. de Geest, Ellen E Stobberingh

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

11 Citations (Scopus)

Abstract

The effect of sucralfate (12.5 mg/ml) on the growth of Escherichia coli (ATCC 25922), Enterococcus faecalis (ATCC 29212) and two isolates of Pseudomonas aeruginosa (ATCC 27853 and a multi-resistant clinical isolate) was studied in vitro at pH values of 3.0, 4.5, 6.0 and 7.4. A bacteriostatic effect of sucralfate was demonstrated for Pseudomonas aeruginosa at a pH of 6.0 and 7.4 and for Escherichia coli and Enterococcus faecalis at a pH of 6.0. The bacteriostatic effect was most pronounced at high pH values. Sucralfate had no bactericidal effect on the bacteria tested at the concentration used. © 1994 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

Original language	English
Pages (from-to)	615-620
Number of pages	6
Journal	European Journal of Clinical Microbiology & Infectious Diseases
Volume	13
Issue number	7
DOIs	https://doi.org/10.1007/BF01971318
Publication status	Published - Jul 1994
Externally published	Yes

Keywords

Bacteria/*drug effects Enterococcus faecalis/drug effects Escherichia coli/drug effects Hydrogen-Ion Concentration Microbial Sensitivity Tests Pseudomonas aeruginosa/drug effects Sucralfate/*pharmacology

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10.1007/BF01971318

http://www.ncbi.nlm.nih.gov/pubmed/7805695

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@article{262907ad5ed9457586de6693db155e75,

title = "In vitro antibacterial activity of sucralfate",

abstract = "The effect of sucralfate (12.5 mg/ml) on the growth of Escherichia coli (ATCC 25922), Enterococcus faecalis (ATCC 29212) and two isolates of Pseudomonas aeruginosa (ATCC 27853 and a multi-resistant clinical isolate) was studied in vitro at pH values of 3.0, 4.5, 6.0 and 7.4. A bacteriostatic effect of sucralfate was demonstrated for Pseudomonas aeruginosa at a pH of 6.0 and 7.4 and for Escherichia coli and Enterococcus faecalis at a pH of 6.0. The bacteriostatic effect was most pronounced at high pH values. Sucralfate had no bactericidal effect on the bacteria tested at the concentration used. {\textcopyright} 1994 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.",

keywords = "Bacteria/*drug effects Enterococcus faecalis/drug effects Escherichia coli/drug effects Hydrogen-Ion Concentration Microbial Sensitivity Tests Pseudomonas aeruginosa/drug effects Sucralfate/*pharmacology",

author = "D Bergmans and M. Bonten and C. Gaillard and {van Tiel}, F. and {de Geest}, S. and Stobberingh, {Ellen E}",

note = "M1 - 7 Bergmans, D Bonten, M Gaillard, C van Tiel, F van der Geest, S Stobberingh, E GERMANY Eur J Clin Microbiol Infect Dis. 1994 Jul;13(7):615-20.",

year = "1994",

month = jul,

doi = "10.1007/BF01971318",

language = "English",

volume = "13",

pages = "615--620",

journal = "European Journal of Clinical Microbiology & Infectious Diseases",

issn = "0934-9723",

publisher = "Springer-Verlag",

number = "7",

}

TY - JOUR

T1 - In vitro antibacterial activity of sucralfate

AU - Bergmans, D

AU - Bonten, M.

AU - Gaillard, C.

AU - van Tiel, F.

AU - de Geest, S.

AU - Stobberingh, Ellen E

N1 - M1 - 7 Bergmans, D Bonten, M Gaillard, C van Tiel, F van der Geest, S Stobberingh, E GERMANY Eur J Clin Microbiol Infect Dis. 1994 Jul;13(7):615-20.

PY - 1994/7

Y1 - 1994/7

N2 - The effect of sucralfate (12.5 mg/ml) on the growth of Escherichia coli (ATCC 25922), Enterococcus faecalis (ATCC 29212) and two isolates of Pseudomonas aeruginosa (ATCC 27853 and a multi-resistant clinical isolate) was studied in vitro at pH values of 3.0, 4.5, 6.0 and 7.4. A bacteriostatic effect of sucralfate was demonstrated for Pseudomonas aeruginosa at a pH of 6.0 and 7.4 and for Escherichia coli and Enterococcus faecalis at a pH of 6.0. The bacteriostatic effect was most pronounced at high pH values. Sucralfate had no bactericidal effect on the bacteria tested at the concentration used. © 1994 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

AB - The effect of sucralfate (12.5 mg/ml) on the growth of Escherichia coli (ATCC 25922), Enterococcus faecalis (ATCC 29212) and two isolates of Pseudomonas aeruginosa (ATCC 27853 and a multi-resistant clinical isolate) was studied in vitro at pH values of 3.0, 4.5, 6.0 and 7.4. A bacteriostatic effect of sucralfate was demonstrated for Pseudomonas aeruginosa at a pH of 6.0 and 7.4 and for Escherichia coli and Enterococcus faecalis at a pH of 6.0. The bacteriostatic effect was most pronounced at high pH values. Sucralfate had no bactericidal effect on the bacteria tested at the concentration used. © 1994 Friedr. Vieweg & Sohn Verlagsgesellschaft mbH.

KW - Bacteria/drug effects Enterococcus faecalis/drug effects Escherichia coli/drug effects Hydrogen-Ion Concentration Microbial Sensitivity Tests Pseudomonas aeruginosa/drug effects Sucralfate/pharmacology

UR - http://www.scopus.com/inward/record.url?scp=0028129803&partnerID=8YFLogxK

U2 - 10.1007/BF01971318

DO - 10.1007/BF01971318

M3 - Article

C2 - 7805695

SN - 0934-9723

VL - 13

SP - 615

EP - 620

JO - European Journal of Clinical Microbiology & Infectious Diseases

JF - European Journal of Clinical Microbiology & Infectious Diseases

IS - 7

ER -

In vitro antibacterial activity of sucralfate

Abstract

Keywords

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