In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains

E. J.M. Verkade; C. J.M.M. Verhulst; X. W. Huijsdens; J. A.J.W. Kluytmans

doi:10.1007/s10096-010-0886-2

In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains

E. J.M. Verkade, C. J.M.M. Verhulst, X. W. Huijsdens, J. A.J.W. Kluytmans

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

The in vitro activity of tigecycline was determined using a well-defined collection of methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 202), including 33 livestock-associated strains. Susceptibility testing was performed using the Etest system. Among the 202 MRSA strains, three (1.5%) had a minimum inhibitory concentration (MIC) value for tigecycline greater than 0.5 mg/l, which are considered to be resistant. When these strains were tested using Iso-Sensitest medium, the MICs were substantially lower and no resistance was found. This discrepancy warrants further investigations into the preferred test conditions for tigecycline. In conclusion, tigecycline showed good activity against MRSA strains in vitro.

Original language	English
Pages (from-to)	503-507
Number of pages	5
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	29
Issue number	5
DOIs	https://doi.org/10.1007/s10096-010-0886-2
Publication status	Published - May 2010
Externally published	Yes

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title = "In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains",

abstract = "The in vitro activity of tigecycline was determined using a well-defined collection of methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 202), including 33 livestock-associated strains. Susceptibility testing was performed using the Etest system. Among the 202 MRSA strains, three (1.5%) had a minimum inhibitory concentration (MIC) value for tigecycline greater than 0.5 mg/l, which are considered to be resistant. When these strains were tested using Iso-Sensitest medium, the MICs were substantially lower and no resistance was found. This discrepancy warrants further investigations into the preferred test conditions for tigecycline. In conclusion, tigecycline showed good activity against MRSA strains in vitro.",

author = "Verkade, {E. J.M.} and Verhulst, {C. J.M.M.} and Huijsdens, {X. W.} and Kluytmans, {J. A.J.W.}",

note = "Funding Information: This study was financially supported by Wyeth",

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language = "English",

volume = "29",

pages = "503--507",

journal = "European Journal of Clinical Microbiology and Infectious Diseases",

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In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains. / Verkade, E. J.M.; Verhulst, C. J.M.M.; Huijsdens, X. W. et al.
In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 29, No. 5, 05.2010, p. 503-507.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains

AU - Verkade, E. J.M.

AU - Verhulst, C. J.M.M.

AU - Huijsdens, X. W.

AU - Kluytmans, J. A.J.W.

N1 - Funding Information: This study was financially supported by Wyeth

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AB - The in vitro activity of tigecycline was determined using a well-defined collection of methicillin-resistant Staphylococcus aureus (MRSA) isolates (n = 202), including 33 livestock-associated strains. Susceptibility testing was performed using the Etest system. Among the 202 MRSA strains, three (1.5%) had a minimum inhibitory concentration (MIC) value for tigecycline greater than 0.5 mg/l, which are considered to be resistant. When these strains were tested using Iso-Sensitest medium, the MICs were substantially lower and no resistance was found. This discrepancy warrants further investigations into the preferred test conditions for tigecycline. In conclusion, tigecycline showed good activity against MRSA strains in vitro.

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ER -

In vitro activity of tigecycline against methicillin-resistant Staphylococcus aureus, including livestock-associated strains

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