In-vitro activity of a new quinolone (CP-99, 219) compared with ciprofloxacin, pefloxacin, azithromycin and penicillin against neisseria gonorrhoeae

The in-vitro activities of CP-99, 219, ciprofloxacin, pefloxacin, azithromycin and penicillin was tested against 114 Neisseria gonorrhoeae strains. The MIG₉₀s were: 0.008 mg/L (MIC range 0.001-0.06 mg/L) for CP-99, 219, 0.008 mg/L (MIC range 0.001-0.25 mg/L) for ciprofloxacin, 0.12 mg/L (MIC range 0.008-4 mg/L) for pefloxacin, 0.25 mg/L (MIC range 0.03-1 mg/L) for azithromycin and 16mg/L (MIC range 0.015-16 mg/L) for penicillin. The activity of CP-99, 219 against various N. gonorrhoeae isolates was comparable to ciprofloxacin.