TY - JOUR
T1 - Improving the Quality of Cerebral Perfusion Maps With Monoenergetic Dual-Energy Computed Tomography Reconstructions
AU - van Ommen, Fasco
AU - Bennink, E
AU - Dankbaar, Jan Willem
AU - Kauw, Frans
AU - de Jong, H.W.A.M.
N1 - Funding Information:
From the *Departments of Radiology and Nuclear Medicine and †Image Sciences Institute, UMC Utrecht, Utrecht, the Netherlands. Received for publication August 30, 2019; accepted November 12, 2019. Correspondence to: Fasco van Ommen, UMC Utrecht, Mail E01.132, PO Box 85500, 3508GA Utrecht, the Netherlands (e‐mail: [email protected]). This research has been made possible by the Dutch Heart Foundation and Technology Foundation STW, as part of their joint strategic research program (project no. 14732): “Earlier Recognition of Cardiovascular Diseases.” The authors declare no conflict of interest. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/RCT.0000000000000981
Publisher Copyright:
© 2020 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - OBJECTIVE: We compared 40- to 70-keV virtual monoenergetic to conventional computed tomography (CT) perfusion reconstructions with respect to quality of perfusion maps. METHODS: Conventional CT perfusion (CTP) images were acquired at 80 kVp in 25 patients, and 40- to 70-keV images were acquired with a dual-layer CT at 120 kVp in 25 patients. First, time-attenuation-curve contrast-to-noise ratio was assessed. Second, the perfusion maps of both groups were qualitatively analyzed by observers. Last, the monoenergetic reconstruction with the highest quality was compared with the clinical standard 80-kVp CTP acquisitions. RESULTS: Contrast-to-noise ratio was significantly better for 40 to 60 keV as compared with 70 keV and conventional images (P < 0.001). Visually, the difference between the blood volume maps among reconstructions was minimal. The 50-keV perfusion maps had the highest quality compared with the other monoenergetic and conventional maps (P < 0.002). CONCLUSIONS: The quality of 50-keV CTP images is superior to the quality of conventional 80- and 120-kVp images.
AB - OBJECTIVE: We compared 40- to 70-keV virtual monoenergetic to conventional computed tomography (CT) perfusion reconstructions with respect to quality of perfusion maps. METHODS: Conventional CT perfusion (CTP) images were acquired at 80 kVp in 25 patients, and 40- to 70-keV images were acquired with a dual-layer CT at 120 kVp in 25 patients. First, time-attenuation-curve contrast-to-noise ratio was assessed. Second, the perfusion maps of both groups were qualitatively analyzed by observers. Last, the monoenergetic reconstruction with the highest quality was compared with the clinical standard 80-kVp CTP acquisitions. RESULTS: Contrast-to-noise ratio was significantly better for 40 to 60 keV as compared with 70 keV and conventional images (P < 0.001). Visually, the difference between the blood volume maps among reconstructions was minimal. The 50-keV perfusion maps had the highest quality compared with the other monoenergetic and conventional maps (P < 0.002). CONCLUSIONS: The quality of 50-keV CTP images is superior to the quality of conventional 80- and 120-kVp images.
KW - CT perfusion
KW - Dual-energy CT
KW - Dual-layer detector CT
KW - Virtual monoenergetic images
UR - http://www.scopus.com/inward/record.url?scp=85100280622&partnerID=8YFLogxK
U2 - 10.1097/RCT.0000000000000981
DO - 10.1097/RCT.0000000000000981
M3 - Article
SN - 0363-8715
VL - 45
SP - 103
EP - 109
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
IS - 1
ER -