Improving ligament tissue engineering by biochemical stimulation of human Bmsc's in a 3d hybrid construct

J. M G Th Jenner; D. B F Saris; L. B. Creemers; F. Van Eijk; W. J. Willems; W. J A Dhert

Improving ligament tissue engineering by biochemical stimulation of human Bmsc's in a 3d hybrid construct

J. M G Th Jenner^*, D. B F Saris, L. B. Creemers, F. Van Eijk, W. J. Willems, W. J A Dhert

^*Corresponding author for this work

Regenerative Medicine and Stem Cells

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic › peer-review

Abstract

The behavior of human Bone Marrow derived Stromal Cells (BMSC) seeded on a 3D biodegradable scaffold and the influence of two growth factors, known for their role in ligament heating was investigated. BMSC's are known for their role in ligament healing, on final construct quality in terms of matrix production and cell differentiation. It was shown that the ligament tissue engineering model posesses stimulatory effects on proliferation and matrix production. The results demonstrate that the used model helps sto gain insight in the complex mechanisms of ligament formation and has the potential to provide a basis for clinical applications.

Original language	English
Title of host publication	Transactions - 7th World Biomaterials Congress
Number of pages	1
Publication status	Published - 1 Dec 2004
Event	Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: 17 May 2004 → 21 May 2004

Conference

Conference	Transactions - 7th World Biomaterials Congress
Country/Territory	Australia
City	Sydney
Period	17/05/04 → 21/05/04

Cite this

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title = "Improving ligament tissue engineering by biochemical stimulation of human Bmsc's in a 3d hybrid construct",

abstract = "The behavior of human Bone Marrow derived Stromal Cells (BMSC) seeded on a 3D biodegradable scaffold and the influence of two growth factors, known for their role in ligament heating was investigated. BMSC's are known for their role in ligament healing, on final construct quality in terms of matrix production and cell differentiation. It was shown that the ligament tissue engineering model posesses stimulatory effects on proliferation and matrix production. The results demonstrate that the used model helps sto gain insight in the complex mechanisms of ligament formation and has the potential to provide a basis for clinical applications.",

author = "Jenner, {J. M G Th} and Saris, {D. B F} and Creemers, {L. B.} and {Van Eijk}, F. and Willems, {W. J.} and Dhert, {W. J A}",

year = "2004",

month = dec,

day = "1",

language = "English",

isbn = "1877040193",

booktitle = "Transactions - 7th World Biomaterials Congress",

note = "Transactions - 7th World Biomaterials Congress ; Conference date: 17-05-2004 Through 21-05-2004",

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T1 - Improving ligament tissue engineering by biochemical stimulation of human Bmsc's in a 3d hybrid construct

AU - Jenner, J. M G Th

AU - Saris, D. B F

AU - Creemers, L. B.

AU - Van Eijk, F.

AU - Willems, W. J.

AU - Dhert, W. J A

PY - 2004/12/1

Y1 - 2004/12/1

N2 - The behavior of human Bone Marrow derived Stromal Cells (BMSC) seeded on a 3D biodegradable scaffold and the influence of two growth factors, known for their role in ligament heating was investigated. BMSC's are known for their role in ligament healing, on final construct quality in terms of matrix production and cell differentiation. It was shown that the ligament tissue engineering model posesses stimulatory effects on proliferation and matrix production. The results demonstrate that the used model helps sto gain insight in the complex mechanisms of ligament formation and has the potential to provide a basis for clinical applications.

AB - The behavior of human Bone Marrow derived Stromal Cells (BMSC) seeded on a 3D biodegradable scaffold and the influence of two growth factors, known for their role in ligament heating was investigated. BMSC's are known for their role in ligament healing, on final construct quality in terms of matrix production and cell differentiation. It was shown that the ligament tissue engineering model posesses stimulatory effects on proliferation and matrix production. The results demonstrate that the used model helps sto gain insight in the complex mechanisms of ligament formation and has the potential to provide a basis for clinical applications.

UR - http://www.scopus.com/inward/record.url?scp=13844271454&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:13844271454

SN - 1877040193

SN - 9781877040191

BT - Transactions - 7th World Biomaterials Congress

T2 - Transactions - 7th World Biomaterials Congress

Y2 - 17 May 2004 through 21 May 2004

ER -

Improving ligament tissue engineering by biochemical stimulation of human Bmsc's in a 3d hybrid construct

Abstract

Conference

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