TY - JOUR
T1 - Improved repeatability of dynamic contrastenhanced MRI using the complex MRI signal to derive arterial input functions: a test-retest study in prostate cancer patients (vol 81, pg 3358, 2019)
T2 - Improved repeatability of dynamic contrast-enhanced MRI using the complex MRI signal to derive arterial input functions: a test-retest study in prostate cancer patients (Magn Reson Med., (2019), 81, (3358–3369), 10.1002/mrm.27646)
AU - Klawer, Edzo M E
AU - van Houdt, Petra J
AU - Simonis, Frank F J
AU - van den Berg, Cornelis A T
AU - Pos, Floris J
AU - Heijmink, Stijn W T P J
AU - Isebaert, Sofie
AU - Haustermans, Karin
AU - van der Heide, Uulke A
N1 - Publisher Copyright:
© 2020 International Society for Magnetic Resonance in Medicine
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - The antilog for the within-subject coefficient of variation (wCV) of log-transformed data was performed incorrectly. This leads to an increase by a factor of about 2 in the numbers in abstract, results section, Figure 4, Tables 2 and 3. Although this affected all wCV values reported in the manuscript, the conclusion remains the same. The authors regret this mistake and apologize for any inconvenience this may have caused. 4 FIGURE (Figure presented.) Bar plot of wCV values for Ktrans and kep for the three AIF methods including 95% CI bars 2 TABLE Median, range and wCV with 95% confidence interval of the AIF curve characteristics between the two consecutive exams (Table presented.) 3 TABLE The wCV between left and right AIFs, per method (magnitude, phase and complex signal), with 95% confidence interval for all curve characteristics (Table presented.) Abstract (changes in wCV values): Results: The wCV for peak height and full-width at half maximum for AIF
COMPLEX (15% and 17%) indicated an improved repeatability compared to AIF
MAGN (28% and 26%) and AIF
PHASE (27% and 16%). This translated in lower wCV values for K
trans (24%) with AIF
COMPLEX in comparison to AIF
MAGN (52%) and AIF
PHASE (32%). For k
ep the wCV was 35% with AIF
MAGN, 29% with AIF
PHASE, and 29% with AIF
COMPLEX. Results section, “3.2 AIF curve characteristics per method”, P6 (changes in numbers): Without a B
1 correction, the peak height ratio for AIF
MAGN increased to 1.5, whereas the wCV increased from 33 to 43%. Results section, “3. Tracer kinetic analysis”, P6 (changes in p-values): The wCV for K
trans obtained with AIF
MAGN was significantly larger than for the other two methods (p = 0.0026 and < 0.001 for AIF
PHASE and AIF
COMPLEX respectively), however, for k
ep the wCV were not significantly larger (p = 0.59 and 0.63 for AIF
PHASE and AIF
COMPLEX respectively). Discussion, P9 (the word “higher” becomes “similar”): However, in general the reported wCV of K
trans in ROIs is similar than what we observe for K
trans obtained with AIF
COMPLEX: range between 12.5% to 57%.
46-50.
AB - The antilog for the within-subject coefficient of variation (wCV) of log-transformed data was performed incorrectly. This leads to an increase by a factor of about 2 in the numbers in abstract, results section, Figure 4, Tables 2 and 3. Although this affected all wCV values reported in the manuscript, the conclusion remains the same. The authors regret this mistake and apologize for any inconvenience this may have caused. 4 FIGURE (Figure presented.) Bar plot of wCV values for Ktrans and kep for the three AIF methods including 95% CI bars 2 TABLE Median, range and wCV with 95% confidence interval of the AIF curve characteristics between the two consecutive exams (Table presented.) 3 TABLE The wCV between left and right AIFs, per method (magnitude, phase and complex signal), with 95% confidence interval for all curve characteristics (Table presented.) Abstract (changes in wCV values): Results: The wCV for peak height and full-width at half maximum for AIF
COMPLEX (15% and 17%) indicated an improved repeatability compared to AIF
MAGN (28% and 26%) and AIF
PHASE (27% and 16%). This translated in lower wCV values for K
trans (24%) with AIF
COMPLEX in comparison to AIF
MAGN (52%) and AIF
PHASE (32%). For k
ep the wCV was 35% with AIF
MAGN, 29% with AIF
PHASE, and 29% with AIF
COMPLEX. Results section, “3.2 AIF curve characteristics per method”, P6 (changes in numbers): Without a B
1 correction, the peak height ratio for AIF
MAGN increased to 1.5, whereas the wCV increased from 33 to 43%. Results section, “3. Tracer kinetic analysis”, P6 (changes in p-values): The wCV for K
trans obtained with AIF
MAGN was significantly larger than for the other two methods (p = 0.0026 and < 0.001 for AIF
PHASE and AIF
COMPLEX respectively), however, for k
ep the wCV were not significantly larger (p = 0.59 and 0.63 for AIF
PHASE and AIF
COMPLEX respectively). Discussion, P9 (the word “higher” becomes “similar”): However, in general the reported wCV of K
trans in ROIs is similar than what we observe for K
trans obtained with AIF
COMPLEX: range between 12.5% to 57%.
46-50.
UR - http://www.scopus.com/inward/record.url?scp=85096924586&partnerID=8YFLogxK
U2 - 10.1002/mrm.28606
DO - 10.1002/mrm.28606
M3 - Comment/Letter to the editor
C2 - 33349974
SN - 0740-3194
VL - 85
SP - 2334
EP - 2336
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 4
ER -