TY - JOUR
T1 - Impacts on prenatal development of the human cerebellum: a systematic review
AU - Koning, Irene V
AU - Tielemans, Myrte J
AU - Hoebeek, Freek E
AU - Ecury-Goossen, Ginette M
AU - Reiss, Irwin K M
AU - Steegers-Theunissen, Regine P M
AU - Dudink, Jeroen
N1 - Publisher Copyright:
© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017
Y1 - 2017
N2 - PURPOSE: The cerebellum is essential for normal neurodevelopment and is particularly susceptible for intra-uterine disruptions. Although some causal prenatal exposures have been identified, the origin of neurodevelopmental disorders remains mostly unclear. Therefore, a systematic literature search was conducted to provide an overview of parental environmental exposures and intrinsic factors influencing prenatal cerebellar growth and development in humans.MATERIALS AND METHODS: The literature search was limited to human studies in the English language and was conducted in Embase, Medline, Cochrane, Web of Science, Pubmed and GoogleScholar. Eligible studies were selected by three independent reviewers and study quality was scored by two independent reviewers.RESULTS: The search yielded 3872 articles. We found 15 eligible studies reporting associations between cerebellar development and maternal smoking (4), use of alcohol (3), in vitro fertilization mediums (1), mercury (1), mifepristone (2), aminopropionitriles (1), ethnicity (2) and cortisol levels (1). No studies reported on paternal factors.CONCLUSIONS: Current literature on associations between parental environmental exposures, intrinsic factors and human cerebellar development is scarce. Yet, this systematic review provided an essential overview of human studies demonstrating the vulnerability of the cerebellum to the intra-uterine environment.
AB - PURPOSE: The cerebellum is essential for normal neurodevelopment and is particularly susceptible for intra-uterine disruptions. Although some causal prenatal exposures have been identified, the origin of neurodevelopmental disorders remains mostly unclear. Therefore, a systematic literature search was conducted to provide an overview of parental environmental exposures and intrinsic factors influencing prenatal cerebellar growth and development in humans.MATERIALS AND METHODS: The literature search was limited to human studies in the English language and was conducted in Embase, Medline, Cochrane, Web of Science, Pubmed and GoogleScholar. Eligible studies were selected by three independent reviewers and study quality was scored by two independent reviewers.RESULTS: The search yielded 3872 articles. We found 15 eligible studies reporting associations between cerebellar development and maternal smoking (4), use of alcohol (3), in vitro fertilization mediums (1), mercury (1), mifepristone (2), aminopropionitriles (1), ethnicity (2) and cortisol levels (1). No studies reported on paternal factors.CONCLUSIONS: Current literature on associations between parental environmental exposures, intrinsic factors and human cerebellar development is scarce. Yet, this systematic review provided an essential overview of human studies demonstrating the vulnerability of the cerebellum to the intra-uterine environment.
U2 - 10.1080/14767058.2016.1253060
DO - 10.1080/14767058.2016.1253060
M3 - Article
C2 - 27806674
SN - 1476-7058
VL - 80
SP - 2461
EP - 2468
JO - Journal of Maternal-fetal & Neonatal Medicine
JF - Journal of Maternal-fetal & Neonatal Medicine
IS - 20
ER -