TY - JOUR
T1 - Impact of increased diagnosis of early HIV infection and immediate antiretroviral treatment initiation on HIV transmission among men who have sex with men in the Netherlands
AU - Teslya, Alexandra
AU - Heijne, Janneke Cornelia Maria
AU - van der Loeff, Maarten Franciscus Schim
AU - van Sighem, Ard
AU - Roberts, Jacob Aiden
AU - Dijkstra, Maartje
AU - de Bree, Godelieve J.
AU - Schmidt, Axel Jeremias
AU - Jonas, Kai J.
AU - Kretzschmar, Mirjam E.
AU - Rozhnova, Ganna
N1 - Publisher Copyright:
© 2025 Teslya et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2025/2
Y1 - 2025/2
N2 - The number of new HIV infections among men who have sex with men (MSM) in the Netherlands has been decreasing, but additional efforts are required to bring it further down. This study aims to assess the impact of increased diagnosis of early HIV infection combined with immediate antiretroviral treatment (ART) initiation on reducing HIV transmission among MSM. We developed an agent-based model calibrated to HIV surveillance and sexual behavior data for MSM in the Netherlands in 2017-2022. Starting in 2023, we simulated a 10-year intervention that accelerates HIV diagnosis during the first 3 or 6 months after HIV acquisition across five levels of increased diagnosis rates (2, 4, 8, 16, and 32-fold), followed by immediate ART initiation. The upper limit of the intervention’s impact over 10 years is projected to result in the cumulative 298 (95-th QI: 162–451) HIV infections averted. A 32-fold increase in the diagnosis rate within 3 months after HIV acquisition (corresponding to 100% of all new HIV infections diagnosed within 3 months of acquisition) results in 269 (95-th QI: 147–400) infections averted, approaching closely maximum impact. By extending the scope of the intervention to individuals who acquired HIV infection within the previous 6 months, a smaller 8-fold increase in the diagnosis rate (corresponding to 97% of new HIV infections diagnosed within 6 months of acquisition) approaches closely the maximum impact of the intervention by averting 256 (95-th QI: 122–411) HIV infections. Our sensitivity analyses showed, that in an epidemiological context similar to the modern-day the Netherlands, immediate initiation of ART accompanying accelerated diagnosis of individuals with early HIV infection does not significantly affect HIV transmission dynamics. Accelerating early HIV diagnosis through increased awareness, screening, and testing can further reduce transmission among MSM. Meeting this goal necessitates a stakeholder needs assessment.
AB - The number of new HIV infections among men who have sex with men (MSM) in the Netherlands has been decreasing, but additional efforts are required to bring it further down. This study aims to assess the impact of increased diagnosis of early HIV infection combined with immediate antiretroviral treatment (ART) initiation on reducing HIV transmission among MSM. We developed an agent-based model calibrated to HIV surveillance and sexual behavior data for MSM in the Netherlands in 2017-2022. Starting in 2023, we simulated a 10-year intervention that accelerates HIV diagnosis during the first 3 or 6 months after HIV acquisition across five levels of increased diagnosis rates (2, 4, 8, 16, and 32-fold), followed by immediate ART initiation. The upper limit of the intervention’s impact over 10 years is projected to result in the cumulative 298 (95-th QI: 162–451) HIV infections averted. A 32-fold increase in the diagnosis rate within 3 months after HIV acquisition (corresponding to 100% of all new HIV infections diagnosed within 3 months of acquisition) results in 269 (95-th QI: 147–400) infections averted, approaching closely maximum impact. By extending the scope of the intervention to individuals who acquired HIV infection within the previous 6 months, a smaller 8-fold increase in the diagnosis rate (corresponding to 97% of new HIV infections diagnosed within 6 months of acquisition) approaches closely the maximum impact of the intervention by averting 256 (95-th QI: 122–411) HIV infections. Our sensitivity analyses showed, that in an epidemiological context similar to the modern-day the Netherlands, immediate initiation of ART accompanying accelerated diagnosis of individuals with early HIV infection does not significantly affect HIV transmission dynamics. Accelerating early HIV diagnosis through increased awareness, screening, and testing can further reduce transmission among MSM. Meeting this goal necessitates a stakeholder needs assessment.
KW - Humans
KW - Male
KW - HIV Infections/drug therapy
KW - Netherlands/epidemiology
KW - Homosexuality, Male/statistics & numerical data
KW - Adult
KW - Early Diagnosis
KW - Anti-Retroviral Agents/therapeutic use
KW - Sexual Behavior/statistics & numerical data
KW - Anti-HIV Agents/therapeutic use
KW - Computational Biology
UR - http://www.scopus.com/inward/record.url?scp=85219148790&partnerID=8YFLogxK
U2 - 10.1371/journal.pcbi.1012055
DO - 10.1371/journal.pcbi.1012055
M3 - Article
C2 - 40014624
AN - SCOPUS:85219148790
SN - 1553-734X
VL - 21
JO - PLoS Computational Biology
JF - PLoS Computational Biology
IS - 2
M1 - e1012055
ER -