Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery

Martina A. Broglie; Sandro J. Stoeckli; Rafael Sauter; Philippe Pasche; Antoine Reinhard; Laurence de Leval; Gerhard F. Huber; Thomas F. Pezier; Alex Soltermann; Roland Giger; Andreas Arnold; Matthias Dettmer; Andre Arnoux; Martin Müller; Stefan Spreitzer; Florian Lang; Mathieu Lutchmaya; Edouard Stauffer; Vittoria Espeli; Francesco Martucci; Massimo Bongiovanni; Diana Foerbs; Wolfram Jochum

doi:10.1002/hed.24865

Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery

Martina A. Broglie^*, Sandro J. Stoeckli, Rafael Sauter, Philippe Pasche, Antoine Reinhard, Laurence de Leval, Gerhard F. Huber, Thomas F. Pezier, Alex Soltermann, Roland Giger, Andreas Arnold, Matthias Dettmer, Andre Arnoux, Martin Müller, Stefan Spreitzer, Florian Lang, Mathieu Lutchmaya, Edouard Stauffer, Vittoria Espeli, Francesco MartucciMassimo Bongiovanni, Diana Foerbs, Wolfram Jochum

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

Background: Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC. Methods: Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors. Results: The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P =.01; DSS 92% vs 76%; P =.03). Patients in the low-risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate-risk group (OS 63%; DSS 83%), and high-risk group (OS 61%; DSS 75%). Conclusion: Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.

Original language	English
Pages (from-to)	2004-2015
Number of pages	12
Journal	Head and Neck
Volume	39
Issue number	10
DOIs	https://doi.org/10.1002/hed.24865
Publication status	Published - 1 Oct 2017
Externally published	Yes

Keywords

human papillomavirus
oropharynx
squamous cell cancer
surgery
survival
Oropharyngeal Neoplasms/mortality
Head and Neck Neoplasms/mortality
Prognosis
Papillomaviridae/genetics
Tissue Array Analysis
Humans
Middle Aged
Risk Factors
Male
Survival Rate
Papillomavirus Infections/complications
Chemoradiotherapy/methods
Squamous Cell Carcinoma of Head and Neck
Aged, 80 and over
Adult
Carcinoma, Squamous Cell/mortality
Female
Aged
Retrospective Studies

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10.1002/hed.24865

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Broglie, M. A., Stoeckli, S. J., Sauter, R., Pasche, P., Reinhard, A., de Leval, L., Huber, G. F., Pezier, T. F., Soltermann, A., Giger, R., Arnold, A., Dettmer, M., Arnoux, A., Müller, M., Spreitzer, S., Lang, F., Lutchmaya, M., Stauffer, E., Espeli, V., ... Jochum, W. (2017). Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery. Head and Neck, 39(10), 2004-2015. https://doi.org/10.1002/hed.24865

@article{ddd39315f0a84c429968302cb77b5307,

title = "Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery",

abstract = "Background: Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC. Methods: Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors. Results: The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P =.01; DSS 92% vs 76%; P =.03). Patients in the low-risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate-risk group (OS 63%; DSS 83%), and high-risk group (OS 61%; DSS 75%). Conclusion: Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.",

keywords = "human papillomavirus, oropharynx, squamous cell cancer, surgery, survival, Oropharyngeal Neoplasms/mortality, Head and Neck Neoplasms/mortality, Prognosis, Papillomaviridae/genetics, Tissue Array Analysis, Humans, Middle Aged, Risk Factors, Male, Survival Rate, Papillomavirus Infections/complications, Chemoradiotherapy/methods, Squamous Cell Carcinoma of Head and Neck, Aged, 80 and over, Adult, Carcinoma, Squamous Cell/mortality, Female, Aged, Retrospective Studies",

author = "Broglie, {Martina A.} and Stoeckli, {Sandro J.} and Rafael Sauter and Philippe Pasche and Antoine Reinhard and {de Leval}, Laurence and Huber, {Gerhard F.} and Pezier, {Thomas F.} and Alex Soltermann and Roland Giger and Andreas Arnold and Matthias Dettmer and Andre Arnoux and Martin M{\"u}ller and Stefan Spreitzer and Florian Lang and Mathieu Lutchmaya and Edouard Stauffer and Vittoria Espeli and Francesco Martucci and Massimo Bongiovanni and Diana Foerbs and Wolfram Jochum",

note = "{\textcopyright} 2017 Wiley Periodicals, Inc.",

year = "2017",

month = oct,

day = "1",

doi = "10.1002/hed.24865",

language = "English",

volume = "39",

pages = "2004--2015",

journal = "Head and Neck",

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Broglie, MA, Stoeckli, SJ, Sauter, R, Pasche, P, Reinhard, A, de Leval, L, Huber, GF, Pezier, TF, Soltermann, A, Giger, R, Arnold, A, Dettmer, M, Arnoux, A, Müller, M, Spreitzer, S, Lang, F, Lutchmaya, M, Stauffer, E, Espeli, V, Martucci, F, Bongiovanni, M, Foerbs, D & Jochum, W 2017, 'Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery', Head and Neck, vol. 39, no. 10, pp. 2004-2015. https://doi.org/10.1002/hed.24865

TY - JOUR

T1 - Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery

AU - Broglie, Martina A.

AU - Stoeckli, Sandro J.

AU - Sauter, Rafael

AU - Pasche, Philippe

AU - Reinhard, Antoine

AU - de Leval, Laurence

AU - Huber, Gerhard F.

AU - Pezier, Thomas F.

AU - Soltermann, Alex

AU - Giger, Roland

AU - Arnold, Andreas

AU - Dettmer, Matthias

AU - Arnoux, Andre

AU - Müller, Martin

AU - Spreitzer, Stefan

AU - Lang, Florian

AU - Lutchmaya, Mathieu

AU - Stauffer, Edouard

AU - Espeli, Vittoria

AU - Martucci, Francesco

AU - Bongiovanni, Massimo

AU - Foerbs, Diana

AU - Jochum, Wolfram

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background: Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC. Methods: Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors. Results: The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P =.01; DSS 92% vs 76%; P =.03). Patients in the low-risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate-risk group (OS 63%; DSS 83%), and high-risk group (OS 61%; DSS 75%). Conclusion: Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.

AB - Background: Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC. Methods: Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors. Results: The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P =.01; DSS 92% vs 76%; P =.03). Patients in the low-risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate-risk group (OS 63%; DSS 83%), and high-risk group (OS 61%; DSS 75%). Conclusion: Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.

KW - human papillomavirus

KW - oropharynx

KW - squamous cell cancer

KW - surgery

KW - survival

KW - Oropharyngeal Neoplasms/mortality

KW - Head and Neck Neoplasms/mortality

KW - Prognosis

KW - Papillomaviridae/genetics

KW - Tissue Array Analysis

KW - Humans

KW - Middle Aged

KW - Risk Factors

KW - Male

KW - Survival Rate

KW - Papillomavirus Infections/complications

KW - Chemoradiotherapy/methods

KW - Squamous Cell Carcinoma of Head and Neck

KW - Aged, 80 and over

KW - Adult

KW - Carcinoma, Squamous Cell/mortality

KW - Female

KW - Aged

KW - Retrospective Studies

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U2 - 10.1002/hed.24865

DO - 10.1002/hed.24865

M3 - Article

C2 - 28691255

AN - SCOPUS:85022341941

SN - 1043-3074

VL - 39

SP - 2004

EP - 2015

JO - Head and Neck

JF - Head and Neck

IS - 10

ER -

Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery

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Keywords

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