TY - JOUR
T1 - Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life
AU - Reyman, Marta
AU - van Houten, Marlies A.
AU - van Baarle, Debbie
AU - Bosch, Astrid A.T.M.
AU - Man, Wing Ho
AU - Chu, Mei Ling J.N.
AU - Arp, Kayleigh
AU - Watson, Rebecca L.
AU - Sanders, Elisabeth A.M.
AU - Fuentes, Susana
AU - Bogaert, Debby
N1 - Funding Information:
The authors are most grateful for the participation of all the children and their families. We would like to acknowledge all the members of the research team of the Spaarne Gasthuis Academy, the Department of Obstetrics and Gynecology of the Spaarne Gas-thuis (Hoofddorp and Haarlem, the Netherlands) and participating midwifery clinics. We would also like to acknowledge Edinburgh Genomics for executing the WGS sequencing and Katherine Emelianova for the bioinformatic analysis of the shotgun sequences. This work was supported in part by the Netherlands Organisation for Scientific Research (NWO-VIDI; grant 91715359) and CSO/NRS Scottish Senior Clinical Fellowship award (SCAF/16/03). The study was co-sponsored by the Spaarne Hospital Hoofdorp and Haarlem and the University Medical Centre Utrecht, The Netherlands.
Funding Information:
E.A.M.S. declares to have received unrestricted research support from Pfizer, grant support for vaccine studies from Pfizer and GSK, and fees paid to the institution for advisory boards or participation in independent data-monitoring committees for Pfizer and GSK. D.B. declares to have received unrestricted fees paid to the institution for advisory work for Friesland Campina and well as research support from Nutricia. None of the fees or grants listed here were received for the research described in this paper. No other authors reported financial disclosures. None of the other authors report competing interests.
Publisher Copyright:
© 2019, The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - The early-life microbiome appears to be affected by mode of delivery, but this effect may depend on intrapartum antibiotic exposure. Here, we assess the effect of delivery mode on gut microbiota, independent of intrapartum antibiotics, by postponing routine antibiotic administration to mothers until after cord clamping in 74 vaginally delivered and 46 caesarean section born infants. The microbiota differs between caesarean section born and vaginally delivered infants over the first year of life, showing enrichment of Bifidobacterium spp., and reduction of Enterococcus and Klebsiella spp. in vaginally delivered infants. The microbiota composition at one week of life is associated with the number of respiratory infections over the first year. The taxa driving this association are more abundant in caesarean section born children, providing a possible link between mode of delivery and susceptibility to infectious outcomes.
AB - The early-life microbiome appears to be affected by mode of delivery, but this effect may depend on intrapartum antibiotic exposure. Here, we assess the effect of delivery mode on gut microbiota, independent of intrapartum antibiotics, by postponing routine antibiotic administration to mothers until after cord clamping in 74 vaginally delivered and 46 caesarean section born infants. The microbiota differs between caesarean section born and vaginally delivered infants over the first year of life, showing enrichment of Bifidobacterium spp., and reduction of Enterococcus and Klebsiella spp. in vaginally delivered infants. The microbiota composition at one week of life is associated with the number of respiratory infections over the first year. The taxa driving this association are more abundant in caesarean section born children, providing a possible link between mode of delivery and susceptibility to infectious outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85074322398&partnerID=8YFLogxK
U2 - 10.1038/s41467-019-13014-7
DO - 10.1038/s41467-019-13014-7
M3 - Article
C2 - 31676793
AN - SCOPUS:85074322398
SN - 2041-1723
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 4997
ER -