Impact of COVID-19 social distancing on viral infection in France: A delayed outbreak of RSV

Céline Delestrain; Kostas Danis; Isabelle Hau; Sylvie Behillil; Marie-Noëlle Billard; Leyla Krajten; Robert Cohen; Louis Bont; Ralph Epaud

doi:10.1002/ppul.25644

Impact of COVID-19 social distancing on viral infection in France: A delayed outbreak of RSV

Céline Delestrain, Kostas Danis, Isabelle Hau, Sylvie Behillil, Marie-Noëlle Billard, Leyla Krajten, Robert Cohen, Louis Bont, Ralph Epaud

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction: COVID-19 pandemic and associated lockdown measures have deeply modified the natural course of seasonal viral infections, such as respiratory syncytial virus (RSV). Methods: We analyzed French national data from three networks: emergency departments (ED) of French hospitals, general practitioners (GP), and hospital laboratories. We compared the number of ED or GP visits for bronchiolitis in children <2 years of age, and the percentage of RSV positive tests in the 2020 to 2021 season with those of the two previous seasons (2018–2019 and 2019–2020). We used time series of the previous 5 years to calculate epidemic thresholds. Results: During the 2020–2021 season, the epidemic begun in February (Week 05) in the Ile de France (Paris and suburbs) region, 12 weeks later compared with the previous seasons and progressively spread across all the French metropolitan regions. The highest number of bronchiolitis cases in 2021 (Week 12) occurred 10–12 weeks after the previous seasonal peaks of previous seasons, but the number of cases remained lower than in the previous seasonal peaks. Conclusion: We identified a delayed RSV epidemic in the period that usually corresponds at the end of the epidemic season, raising concerns for the burden of RSV in the already strained healthcare systems during the COVID-19 pandemic.

Original language	English
Pages (from-to)	3669-3673
Number of pages	5
Journal	Pediatric Pulmonology
Volume	56
Issue number	12
Early online date	2 Sept 2021
DOIs	https://doi.org/10.1002/ppul.25644
Publication status	Published - Dec 2021

Keywords

bronchiolitis
covid-19
epidemic
respiratory syncytial virus

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10.1002/ppul.25644

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@article{23718f4725f74fa985e9661f05782f3a,

title = "Impact of COVID-19 social distancing on viral infection in France: A delayed outbreak of RSV",

abstract = "Introduction: COVID-19 pandemic and associated lockdown measures have deeply modified the natural course of seasonal viral infections, such as respiratory syncytial virus (RSV). Methods: We analyzed French national data from three networks: emergency departments (ED) of French hospitals, general practitioners (GP), and hospital laboratories. We compared the number of ED or GP visits for bronchiolitis in children <2 years of age, and the percentage of RSV positive tests in the 2020 to 2021 season with those of the two previous seasons (2018–2019 and 2019–2020). We used time series of the previous 5 years to calculate epidemic thresholds. Results: During the 2020–2021 season, the epidemic begun in February (Week 05) in the Ile de France (Paris and suburbs) region, 12 weeks later compared with the previous seasons and progressively spread across all the French metropolitan regions. The highest number of bronchiolitis cases in 2021 (Week 12) occurred 10–12 weeks after the previous seasonal peaks of previous seasons, but the number of cases remained lower than in the previous seasonal peaks. Conclusion: We identified a delayed RSV epidemic in the period that usually corresponds at the end of the epidemic season, raising concerns for the burden of RSV in the already strained healthcare systems during the COVID-19 pandemic.",

keywords = "bronchiolitis, covid-19, epidemic, respiratory syncytial virus",

author = "C{\'e}line Delestrain and Kostas Danis and Isabelle Hau and Sylvie Behillil and Marie-No{\"e}lle Billard and Leyla Krajten and Robert Cohen and Louis Bont and Ralph Epaud",

note = "Funding Information: We are grateful for the French networks: All GPs, pediatricians, and their patients for providing the samples tested. For the French hospital laboratory network, hospital emergency department staff from the OSCOUR network, RENAL network laboratories: Ile de France, Ambroise Pare, Avicenne, Bichat, Bic{\^e}tre, Henri Mondor, Versailles, Necker, Paul Brousse, Pitie Salpetri{\`e}re, Robert Debr{\'e}, Saint-Louis, Cochin, Trousseau-Saint Antoine-Tenon, Pontoise, Poissy, and Foch. Other regions: Strasbourg, Dijon, Reims, Nancy, Besan{\c c}on, Lille, Amiens, Caen, Brest, Rennes, Orl{\'e}ans, Tours, Rouen, Angers, Nantes, Aix-en-Provence, Annecy, Bordeaux, Chamb{\'e}ry, Clermont-Ferrand, Grenoble, Limoges, Lyon, Marseille, Montpellier, Nice, Poitiers, Saint-Etienne, and Toulouse. Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC",

year = "2021",

month = dec,

doi = "10.1002/ppul.25644",

language = "English",

volume = "56",

pages = "3669--3673",

journal = "Pediatric Pulmonology",

issn = "8755-6863",

publisher = "Wiley-Liss Inc.",

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T1 - Impact of COVID-19 social distancing on viral infection in France

T2 - A delayed outbreak of RSV

AU - Delestrain, Céline

AU - Danis, Kostas

AU - Hau, Isabelle

AU - Behillil, Sylvie

AU - Billard, Marie-Noëlle

AU - Krajten, Leyla

AU - Cohen, Robert

AU - Bont, Louis

AU - Epaud, Ralph

N1 - Funding Information: We are grateful for the French networks: All GPs, pediatricians, and their patients for providing the samples tested. For the French hospital laboratory network, hospital emergency department staff from the OSCOUR network, RENAL network laboratories: Ile de France, Ambroise Pare, Avicenne, Bichat, Bicêtre, Henri Mondor, Versailles, Necker, Paul Brousse, Pitie Salpetrière, Robert Debré, Saint-Louis, Cochin, Trousseau-Saint Antoine-Tenon, Pontoise, Poissy, and Foch. Other regions: Strasbourg, Dijon, Reims, Nancy, Besançon, Lille, Amiens, Caen, Brest, Rennes, Orléans, Tours, Rouen, Angers, Nantes, Aix-en-Provence, Annecy, Bordeaux, Chambéry, Clermont-Ferrand, Grenoble, Limoges, Lyon, Marseille, Montpellier, Nice, Poitiers, Saint-Etienne, and Toulouse. Publisher Copyright: © 2021 Wiley Periodicals LLC

PY - 2021/12

Y1 - 2021/12

N2 - Introduction: COVID-19 pandemic and associated lockdown measures have deeply modified the natural course of seasonal viral infections, such as respiratory syncytial virus (RSV). Methods: We analyzed French national data from three networks: emergency departments (ED) of French hospitals, general practitioners (GP), and hospital laboratories. We compared the number of ED or GP visits for bronchiolitis in children <2 years of age, and the percentage of RSV positive tests in the 2020 to 2021 season with those of the two previous seasons (2018–2019 and 2019–2020). We used time series of the previous 5 years to calculate epidemic thresholds. Results: During the 2020–2021 season, the epidemic begun in February (Week 05) in the Ile de France (Paris and suburbs) region, 12 weeks later compared with the previous seasons and progressively spread across all the French metropolitan regions. The highest number of bronchiolitis cases in 2021 (Week 12) occurred 10–12 weeks after the previous seasonal peaks of previous seasons, but the number of cases remained lower than in the previous seasonal peaks. Conclusion: We identified a delayed RSV epidemic in the period that usually corresponds at the end of the epidemic season, raising concerns for the burden of RSV in the already strained healthcare systems during the COVID-19 pandemic.

AB - Introduction: COVID-19 pandemic and associated lockdown measures have deeply modified the natural course of seasonal viral infections, such as respiratory syncytial virus (RSV). Methods: We analyzed French national data from three networks: emergency departments (ED) of French hospitals, general practitioners (GP), and hospital laboratories. We compared the number of ED or GP visits for bronchiolitis in children <2 years of age, and the percentage of RSV positive tests in the 2020 to 2021 season with those of the two previous seasons (2018–2019 and 2019–2020). We used time series of the previous 5 years to calculate epidemic thresholds. Results: During the 2020–2021 season, the epidemic begun in February (Week 05) in the Ile de France (Paris and suburbs) region, 12 weeks later compared with the previous seasons and progressively spread across all the French metropolitan regions. The highest number of bronchiolitis cases in 2021 (Week 12) occurred 10–12 weeks after the previous seasonal peaks of previous seasons, but the number of cases remained lower than in the previous seasonal peaks. Conclusion: We identified a delayed RSV epidemic in the period that usually corresponds at the end of the epidemic season, raising concerns for the burden of RSV in the already strained healthcare systems during the COVID-19 pandemic.

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KW - covid-19

KW - epidemic

KW - respiratory syncytial virus

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DO - 10.1002/ppul.25644

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SN - 8755-6863

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EP - 3673

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

IS - 12

ER -

Impact of COVID-19 social distancing on viral infection in France: A delayed outbreak of RSV

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