Impact of controlled ovarian hyperstimulation on thyroid function

Kathrin Fleischer; Alex F. Muller; Femke P. Hohmann; Frank H. De Jong; Marinus J C Eijkemans; Bart Fauser; Joop S E Laven

doi:10.4137/RBi.s13450

Impact of controlled ovarian hyperstimulation on thyroid function

Kathrin Fleischer^*
, Alex F. Muller
, Femke P. Hohmann
, Frank H. De Jong
, Marinus J C Eijkemans
, Bart Fauser
, Joop S E Laven

^*Corresponding author for this work

Child Health

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To compare the effects of different protocols of controlled ovarian hyperstimulation on thyroid function with those of the natural menstrual cycle. STUDY DESIGN: Prospective controlled study. SETTING: University Medical Center. PATIENTS: A total of 97 women without a history of endocrine disease undergoing intrauterine insemination either in a natural cycle, or with mild ovarian hyperstimulation, or in vitro fertilization (IVF). MAIN OUTCOME MEASURES: estradiol (E₂), thyroxine binding globulin (TBG), free thyroxine (FT₄), total thyroxine (TT₄) and thyroid stimulating hormone (TSH) during the midluteal phase. RESULTS: In the IVF group midluteal E₂, TBG, and TT₄ were significantly higher; midluteal FT₄ was significantly lower (mean difference: -1.46 pmol/L; P <0.001) and midluteal TSH was significantly higher (mean difference: 0.52 mU/L; P = 0.015). CONCLUSIONS: Ovarian hyperstimulation in IVF is associated with lower midluteal FT₄. and higher midluteal TSH levels compared to the natural cycle.

Original language	English
Pages (from-to)	9-16
Number of pages	8
Journal	Reproductive Biology Insights
Volume	7
Issue number	1
DOIs	https://doi.org/10.4137/RBi.s13450
Publication status	Published - 2014

Keywords

Assisted reproductive technology (ART)
Neurodevelopmental delay
Ovarian hyperstimulation
Thyroid function

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title = "Impact of controlled ovarian hyperstimulation on thyroid function",

abstract = "OBJECTIVE: To compare the effects of different protocols of controlled ovarian hyperstimulation on thyroid function with those of the natural menstrual cycle. STUDY DESIGN: Prospective controlled study. SETTING: University Medical Center. PATIENTS: A total of 97 women without a history of endocrine disease undergoing intrauterine insemination either in a natural cycle, or with mild ovarian hyperstimulation, or in vitro fertilization (IVF). MAIN OUTCOME MEASURES: estradiol (E2), thyroxine binding globulin (TBG), free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) during the midluteal phase. RESULTS: In the IVF group midluteal E2, TBG, and TT4 were significantly higher; midluteal FT4 was significantly lower (mean difference: -1.46 pmol/L; P <0.001) and midluteal TSH was significantly higher (mean difference: 0.52 mU/L; P = 0.015). CONCLUSIONS: Ovarian hyperstimulation in IVF is associated with lower midluteal FT4. and higher midluteal TSH levels compared to the natural cycle.",

keywords = "Assisted reproductive technology (ART), Neurodevelopmental delay, Ovarian hyperstimulation, Thyroid function",

author = "Kathrin Fleischer and Muller, \{Alex F.\} and Hohmann, \{Femke P.\} and \{De Jong\}, \{Frank H.\} and Eijkemans, \{Marinus J C\} and Bart Fauser and Laven, \{Joop S E\}",

year = "2014",

doi = "10.4137/RBi.s13450",

language = "English",

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pages = "9--16",

journal = "Reproductive Biology Insights",

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T1 - Impact of controlled ovarian hyperstimulation on thyroid function

AU - Fleischer, Kathrin

AU - Muller, Alex F.

AU - Hohmann, Femke P.

AU - De Jong, Frank H.

AU - Eijkemans, Marinus J C

AU - Fauser, Bart

AU - Laven, Joop S E

PY - 2014

Y1 - 2014

N2 - OBJECTIVE: To compare the effects of different protocols of controlled ovarian hyperstimulation on thyroid function with those of the natural menstrual cycle. STUDY DESIGN: Prospective controlled study. SETTING: University Medical Center. PATIENTS: A total of 97 women without a history of endocrine disease undergoing intrauterine insemination either in a natural cycle, or with mild ovarian hyperstimulation, or in vitro fertilization (IVF). MAIN OUTCOME MEASURES: estradiol (E2), thyroxine binding globulin (TBG), free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) during the midluteal phase. RESULTS: In the IVF group midluteal E2, TBG, and TT4 were significantly higher; midluteal FT4 was significantly lower (mean difference: -1.46 pmol/L; P <0.001) and midluteal TSH was significantly higher (mean difference: 0.52 mU/L; P = 0.015). CONCLUSIONS: Ovarian hyperstimulation in IVF is associated with lower midluteal FT4. and higher midluteal TSH levels compared to the natural cycle.

AB - OBJECTIVE: To compare the effects of different protocols of controlled ovarian hyperstimulation on thyroid function with those of the natural menstrual cycle. STUDY DESIGN: Prospective controlled study. SETTING: University Medical Center. PATIENTS: A total of 97 women without a history of endocrine disease undergoing intrauterine insemination either in a natural cycle, or with mild ovarian hyperstimulation, or in vitro fertilization (IVF). MAIN OUTCOME MEASURES: estradiol (E2), thyroxine binding globulin (TBG), free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) during the midluteal phase. RESULTS: In the IVF group midluteal E2, TBG, and TT4 were significantly higher; midluteal FT4 was significantly lower (mean difference: -1.46 pmol/L; P <0.001) and midluteal TSH was significantly higher (mean difference: 0.52 mU/L; P = 0.015). CONCLUSIONS: Ovarian hyperstimulation in IVF is associated with lower midluteal FT4. and higher midluteal TSH levels compared to the natural cycle.

KW - Assisted reproductive technology (ART)

KW - Neurodevelopmental delay

KW - Ovarian hyperstimulation

KW - Thyroid function

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DO - 10.4137/RBi.s13450

M3 - Article

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EP - 16

JO - Reproductive Biology Insights

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ER -

Impact of controlled ovarian hyperstimulation on thyroid function

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