TY - JOUR
T1 - Impact of controlled ovarian hyperstimulation on thyroid function
AU - Fleischer, Kathrin
AU - Muller, Alex F.
AU - Hohmann, Femke P.
AU - De Jong, Frank H.
AU - Eijkemans, Marinus J C
AU - Fauser, Bart
AU - Laven, Joop S E
PY - 2014
Y1 - 2014
N2 - OBJECTIVE: To compare the effects of different protocols of controlled ovarian hyperstimulation on thyroid function with those of the natural menstrual cycle. STUDY DESIGN: Prospective controlled study. SETTING: University Medical Center. PATIENTS: A total of 97 women without a history of endocrine disease undergoing intrauterine insemination either in a natural cycle, or with mild ovarian hyperstimulation, or in vitro fertilization (IVF). MAIN OUTCOME MEASURES: estradiol (E2), thyroxine binding globulin (TBG), free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) during the midluteal phase. RESULTS: In the IVF group midluteal E2, TBG, and TT4 were significantly higher; midluteal FT4 was significantly lower (mean difference: -1.46 pmol/L; P <0.001) and midluteal TSH was significantly higher (mean difference: 0.52 mU/L; P = 0.015). CONCLUSIONS: Ovarian hyperstimulation in IVF is associated with lower midluteal FT4. and higher midluteal TSH levels compared to the natural cycle.
AB - OBJECTIVE: To compare the effects of different protocols of controlled ovarian hyperstimulation on thyroid function with those of the natural menstrual cycle. STUDY DESIGN: Prospective controlled study. SETTING: University Medical Center. PATIENTS: A total of 97 women without a history of endocrine disease undergoing intrauterine insemination either in a natural cycle, or with mild ovarian hyperstimulation, or in vitro fertilization (IVF). MAIN OUTCOME MEASURES: estradiol (E2), thyroxine binding globulin (TBG), free thyroxine (FT4), total thyroxine (TT4) and thyroid stimulating hormone (TSH) during the midluteal phase. RESULTS: In the IVF group midluteal E2, TBG, and TT4 were significantly higher; midluteal FT4 was significantly lower (mean difference: -1.46 pmol/L; P <0.001) and midluteal TSH was significantly higher (mean difference: 0.52 mU/L; P = 0.015). CONCLUSIONS: Ovarian hyperstimulation in IVF is associated with lower midluteal FT4. and higher midluteal TSH levels compared to the natural cycle.
KW - Assisted reproductive technology (ART)
KW - Neurodevelopmental delay
KW - Ovarian hyperstimulation
KW - Thyroid function
UR - http://www.scopus.com/inward/record.url?scp=84902952253&partnerID=8YFLogxK
U2 - 10.4137/RBi.s13450
DO - 10.4137/RBi.s13450
M3 - Article
AN - SCOPUS:84902952253
VL - 7
SP - 9
EP - 16
JO - Reproductive Biology Insights
JF - Reproductive Biology Insights
IS - 1
ER -