Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults

Eline Boon, Winette T A van der Graaf, Hans Gelderblom, Margot E T Tesselaar, Robert J.J. van Es, Sjoukje F Oosting, Remco de Bree, Esther van Meerten, Ann Hoeben, Ludi E. Smeele, Stefan M. Willems, Max J H Witjes, Jan Buter, Robert J Baatenburg de Jong, Uta E. Flucke, Petronella G.M. Peer, Judith V.M.G. Bovée, Carla M L Van Herpen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: There is an ongoing debate about the value of (neo-)adjuvant chemotherapy in high- and intermediate-grade osteosarcoma of the head and neck. Methods: All records of patients older than 16 years diagnosed with osteosarcoma of the head and neck in the Netherlands between 1993 and 2013 were reviewed. Results: We identified a total of 77 patients with an osteosarcoma of the head and neck; the 5-year overall survival (OS) was 55%. In 50 patients with surgically resected high- or intermediate-grade osteosarcoma of the head and neck younger than 75 years, univariate and multivariable analysis, adjusting for age and resection margins, showed that patients who had not received chemotherapy had a significantly higher risk of local recurrence (hazard ratio [HR] = 3.78 and 3.66, respectively). Conclusion: In patients younger than 75 years of age with surgically resected high- and intermediate-grade osteosarcoma of the head and neck, treatment with (neo-)adjuvant chemotherapy resulted in a significantly smaller risk of local recurrence. Therefore, we suggest (neo-)adjuvant chemotherapy in patients amenable to chemotherapy.

Original languageEnglish
Pages (from-to)140-146
Number of pages7
JournalHead and Neck
Volume39
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • (neo-)adjuvant
  • chemotherapy
  • head and neck neoplasms
  • mandible
  • maxilla
  • osteosarcoma

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