Immunologie in de medische praktijk. XXXII. Transplantatie van autologe hematopoetische stamcellen voor de behandeling van therapieresistente auto-immuunziekten; eerste gunstige ervaringen bij 35 patienten

A. M. Vlieger; F. H J Van Den Hoogen; D. M C Brinkman; J. M. Van Laar; M. Schipperus; A. A. Kruize; N. M. Wulffraat

Immunologie in de medische praktijk. XXXII. Transplantatie van autologe hematopoetische stamcellen voor de behandeling van therapieresistente auto-immuunziekten; eerste gunstige ervaringen bij 35 patienten

Translated title of the contribution: Immunology in medical practice. XXXII. Autologous haematopoietic stem cell transplantation for therapy-resistant autoimmune diseases; first favourable results in 35 patients

A. M. Vlieger, F. H J Van Den Hoogen, D. M C Brinkman, J. M. Van Laar, M. Schipperus, A. A. Kruize, N. M. Wulffraat^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The objective of this study was to document the experiences in the first Dutch pilot studies of the effect of transplantation of autologous haematopoietic stem cells in patients with therapy-resistant autoimmune disease. The first results in 21 adults and 14 children are promising: remission of the disease was achieved in 13 patients, while in the others a significant reduction of disease activity was seen with a corresponding improvement of the quality of life. Infectious complications were frequently observed. Two children with systemic juvenile idiopathic arthritis developed a fatal infection-associated macrophage activation syndrome. Multicentre randomised studies are necessary to study the effects of autologous stem cell transplantation and modifications such as T-cell depletion.

Translated title of the contribution	Immunology in medical practice. XXXII. Autologous haematopoietic stem cell transplantation for therapy-resistant autoimmune diseases; first favourable results in 35 patients
Original language	Dutch
Pages (from-to)	1588-1592
Number of pages	5
Journal	Nederlands Tijdschrift voor Geneeskunde
Volume	144
Issue number	33
Publication status	Published - 12 Aug 2000

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Vlieger, A. M., Van Den Hoogen, F. H. J., Brinkman, D. M. C., Van Laar, J. M., Schipperus, M., Kruize, A. A., & Wulffraat, N. M. (2000). Immunologie in de medische praktijk. XXXII. Transplantatie van autologe hematopoetische stamcellen voor de behandeling van therapieresistente auto-immuunziekten; eerste gunstige ervaringen bij 35 patienten. Nederlands Tijdschrift voor Geneeskunde, 144(33), 1588-1592.

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title = "Immunologie in de medische praktijk. XXXII. Transplantatie van autologe hematopoetische stamcellen voor de behandeling van therapieresistente auto-immuunziekten; eerste gunstige ervaringen bij 35 patienten",

abstract = "The objective of this study was to document the experiences in the first Dutch pilot studies of the effect of transplantation of autologous haematopoietic stem cells in patients with therapy-resistant autoimmune disease. The first results in 21 adults and 14 children are promising: remission of the disease was achieved in 13 patients, while in the others a significant reduction of disease activity was seen with a corresponding improvement of the quality of life. Infectious complications were frequently observed. Two children with systemic juvenile idiopathic arthritis developed a fatal infection-associated macrophage activation syndrome. Multicentre randomised studies are necessary to study the effects of autologous stem cell transplantation and modifications such as T-cell depletion.",

author = "Vlieger, {A. M.} and {Van Den Hoogen}, {F. H J} and Brinkman, {D. M C} and {Van Laar}, {J. M.} and M. Schipperus and Kruize, {A. A.} and Wulffraat, {N. M.}",

year = "2000",

month = aug,

day = "12",

language = "Dutch",

volume = "144",

pages = "1588--1592",

journal = "Nederlands Tijdschrift voor Geneeskunde",

issn = "0028-2162",

publisher = "Bohn Stafleu van Loghum",

number = "33",

}

Vlieger, AM, Van Den Hoogen, FHJ, Brinkman, DMC, Van Laar, JM, Schipperus, M, Kruize, AA & Wulffraat, NM 2000, 'Immunologie in de medische praktijk. XXXII. Transplantatie van autologe hematopoetische stamcellen voor de behandeling van therapieresistente auto-immuunziekten; eerste gunstige ervaringen bij 35 patienten', Nederlands Tijdschrift voor Geneeskunde, vol. 144, no. 33, pp. 1588-1592.

Immunologie in de medische praktijk. XXXII. Transplantatie van autologe hematopoetische stamcellen voor de behandeling van therapieresistente auto-immuunziekten; eerste gunstige ervaringen bij 35 patienten. / Vlieger, A. M.; Van Den Hoogen, F. H J; Brinkman, D. M C et al.
In: Nederlands Tijdschrift voor Geneeskunde, Vol. 144, No. 33, 12.08.2000, p. 1588-1592.

Research output: Contribution to journal › Article › Academic › peer-review

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AU - Wulffraat, N. M.

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AB - The objective of this study was to document the experiences in the first Dutch pilot studies of the effect of transplantation of autologous haematopoietic stem cells in patients with therapy-resistant autoimmune disease. The first results in 21 adults and 14 children are promising: remission of the disease was achieved in 13 patients, while in the others a significant reduction of disease activity was seen with a corresponding improvement of the quality of life. Infectious complications were frequently observed. Two children with systemic juvenile idiopathic arthritis developed a fatal infection-associated macrophage activation syndrome. Multicentre randomised studies are necessary to study the effects of autologous stem cell transplantation and modifications such as T-cell depletion.

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Immunologie in de medische praktijk. XXXII. Transplantatie van autologe hematopoetische stamcellen voor de behandeling van therapieresistente auto-immuunziekten; eerste gunstige ervaringen bij 35 patienten

Abstract

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