TY - JOUR
T1 - Immunological characterization of conjugated Haemophilus influenzae type b vaccine failure in infants
AU - Breukels, Mijke A.
AU - Spanjaard, Lodewijk
AU - Sanders, Lieke A.M.
AU - Rijkers, Ger T.
N1 - Funding Information:
Financial support: Netherlands Organization for Scientific Research (NWO) Medical Research Foundation (grant 920-02-091).
PY - 2001/6/15
Y1 - 2001/6/15
N2 - Infant vaccination with conjugated Haemophilus influenzae type b (Hib) vaccine is highly effective in protecting against invasive Hib infections, but vaccine failures do occur. Twenty-one vaccine failures are reported since the introduction of the Hib conjugate vaccine in The Netherlands. Of the 14 evaluable patients, 6 children showed no antibody response to Hib polysaccharide in convalescent-phase serum (immunoglobulin [Ig] G anti-Hib level <1.0 μg/mL), including 1 child with hypogammaglobulinemia and 1 child with IgG2 deficiency. After revaccination, almost all children developed anti-Hib antibodies. In case of Hib vaccine failure, case investigation should be performed, including measurement of serum Ig concentrations as well as specific anti-Hib antibodies. Invasive Hib disease after infant conjugate Hib vaccination may be the presentation of an underlying immunodeficiency, but more often, only a decreased antibody response to Hib is found; revaccination with conjugated Hib vaccine is advised.
AB - Infant vaccination with conjugated Haemophilus influenzae type b (Hib) vaccine is highly effective in protecting against invasive Hib infections, but vaccine failures do occur. Twenty-one vaccine failures are reported since the introduction of the Hib conjugate vaccine in The Netherlands. Of the 14 evaluable patients, 6 children showed no antibody response to Hib polysaccharide in convalescent-phase serum (immunoglobulin [Ig] G anti-Hib level <1.0 μg/mL), including 1 child with hypogammaglobulinemia and 1 child with IgG2 deficiency. After revaccination, almost all children developed anti-Hib antibodies. In case of Hib vaccine failure, case investigation should be performed, including measurement of serum Ig concentrations as well as specific anti-Hib antibodies. Invasive Hib disease after infant conjugate Hib vaccination may be the presentation of an underlying immunodeficiency, but more often, only a decreased antibody response to Hib is found; revaccination with conjugated Hib vaccine is advised.
UR - http://www.scopus.com/inward/record.url?scp=0035004062&partnerID=8YFLogxK
U2 - 10.1086/320755
DO - 10.1086/320755
M3 - Article
C2 - 11360210
AN - SCOPUS:0035004062
SN - 1058-4838
VL - 32
SP - 1700
EP - 1705
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 12
ER -