TY - JOUR
T1 - Immunohistochemical expression of stem cell markers in pheochromocytomas/paragangliomas is associated with SDHx mutations
AU - Oudijk, L.
AU - Neuhofer, C. M.
AU - Lichtenauer, U. D.
AU - Papathomas, T. G.
AU - Korpershoek, E.
AU - Stoop, H.
AU - Oosterhuis, J. W.
AU - Smid, M.
AU - Restuccia, D. F.
AU - Robledo, M.
AU - De Cubas, A. A.
AU - Mannelli, M.
AU - Gimenez-Roqueplo, A. P.
AU - Dinjens, W. N M
AU - Beuschlein, F.
AU - De Krijger, R. R.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Objective: Pheochromocytomas (PCCs) are neuroendocrine tumors that occur in the adrenal medulla, whereas paragangliomas (PGLs) arise from paraganglia in the head, neck, thorax, or abdomen. In a variety of tumors, cancer cells with stem cell-like properties seem to form the basis of tumor initiation because of their ability to self-renew and proliferate. Specifically targeting this small cell population wmay lay the foundation for more effective therapeutic approaches. In the present study, we intended to identify stem cells in PCCs/PGLs. Design: We examined the immunohistochemical expression of 11 stem cell markers (SOX2, LIN28, NGFR, THY1, PREF1, SOX17, NESTIN, CD117, OCT3/4, NANOG, and CD133) on tissue microarrays containing 208 PCCs/PGLs with different genetic backgrounds from five European centers. Results: SOX2, LIN28, NGFR, and THY1 were expressed in more than 10% of tumors, and PREF1, SOX17, NESTIN, and CD117 were expressed in
AB - Objective: Pheochromocytomas (PCCs) are neuroendocrine tumors that occur in the adrenal medulla, whereas paragangliomas (PGLs) arise from paraganglia in the head, neck, thorax, or abdomen. In a variety of tumors, cancer cells with stem cell-like properties seem to form the basis of tumor initiation because of their ability to self-renew and proliferate. Specifically targeting this small cell population wmay lay the foundation for more effective therapeutic approaches. In the present study, we intended to identify stem cells in PCCs/PGLs. Design: We examined the immunohistochemical expression of 11 stem cell markers (SOX2, LIN28, NGFR, THY1, PREF1, SOX17, NESTIN, CD117, OCT3/4, NANOG, and CD133) on tissue microarrays containing 208 PCCs/PGLs with different genetic backgrounds from five European centers. Results: SOX2, LIN28, NGFR, and THY1 were expressed in more than 10% of tumors, and PREF1, SOX17, NESTIN, and CD117 were expressed in
UR - https://www.scopus.com/pages/publications/84935120768
U2 - 10.1530/EJE-14-1164
DO - 10.1530/EJE-14-1164
M3 - Article
C2 - 25916394
AN - SCOPUS:84935120768
SN - 0804-4643
VL - 173
SP - 43
EP - 52
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
IS - 1
ER -