Immune-microbiota interactions in health and disease

Noah W Palm, Marcel R de Zoete, Richard A Flavell

Research output: Contribution to journalReview articlepeer-review


Recent studies have revealed that the intestinal microbiota plays an important role in host physiology and pathophysiology in health and disease. One of the major mechanisms by which the gut microbiota influences the host is through its interactions with and effects on the host immune system. In this review, we discuss the reciprocal interactions between the host immune system and the gut microbiota, with a particular focus on individual microbes that impact the host through dramatic and specific interactions with the adaptive immune system. We highlight the idea that the presence or absence of specific immunologically important members of the microbiota can determine disease susceptibility and propose that the identification and characterization of these bacteria in humans will eventually allow us to elucidate the role of microbiota composition in human disease.

Original languageEnglish
Pages (from-to)122-127
Number of pages6
JournalClinical Immunology
Issue number2
Publication statusPublished - Aug 2015
Externally publishedYes


  • Adaptive Immunity/immunology
  • B-Lymphocytes/immunology
  • Gastrointestinal Microbiome/immunology
  • Humans
  • Immune System/immunology
  • Immunity, Innate/immunology
  • Immunoglobulin A/immunology
  • Inflammation
  • Intestines/immunology
  • Symbiosis
  • T-Lymphocytes/immunology


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