Imaging of High-Risk Neuroblastoma: Recommendations From SIOPEN Radiology and Nuclear Medicine Specialty Committees

Annemieke Littooij; Catia Olianti; Herve Brisse; Pier Luigi Di Paolo; Maria Garganese; Tepas Kapadia; Jurgen Schaefer; Hugh Wallace; Simon Wan; Bart de Keizer; Irmina Sefic Pasic; Julian Rogasch

doi:10.1002/1545-5017.70180

Imaging of High-Risk Neuroblastoma: Recommendations From SIOPEN Radiology and Nuclear Medicine Specialty Committees

Annemieke Littooij^*
, Catia Olianti
, Herve Brisse
, Pier Luigi Di Paolo
, Maria Garganese
, Tepas Kapadia
, Jurgen Schaefer
, Hugh Wallace
, Simon Wan
, Bart de Keizer
, Irmina Sefic Pasic
, Julian Rogasch

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees developed consensus-based imaging recommendations for high-risk neuroblastoma at first presentation and throughout follow-up. These expert opinions aim to improve reproducibility and enhance diagnostic performance in order to advance the current standard of care and assist in the development of future trials.

Original language	English
Article number	e70180
Journal	Pediatric Blood and Cancer
Volume	73
Issue number	5
Early online date	13 Mar 2026
DOIs	https://doi.org/10.1002/1545-5017.70180
Publication status	Published - May 2026

Keywords

computed tomography
high-risk neuroblastoma
imaging
magnetic resonance imaging
neuroblastoma response assessment
nuclear medicine
pediatric neuroblastoma diagnosis

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Pediatric Blood Cancer - 2026 - Littooij - Imaging of High‐Risk Neuroblastoma Recommendations From SIOPEN Radiology andFinal published version, 2.72 MBLicence: CC BY-NC

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Littooij, A., Olianti, C., Brisse, H., Di Paolo, P. L., Garganese, M., Kapadia, T., Schaefer, J., Wallace, H., Wan, S., de Keizer, B., Sefic Pasic, I., & Rogasch, J. (2026). Imaging of High-Risk Neuroblastoma: Recommendations From SIOPEN Radiology and Nuclear Medicine Specialty Committees. Pediatric Blood and Cancer, 73(5), Article e70180. https://doi.org/10.1002/1545-5017.70180

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title = "Imaging of High-Risk Neuroblastoma: Recommendations From SIOPEN Radiology and Nuclear Medicine Specialty Committees",

abstract = "Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees developed consensus-based imaging recommendations for high-risk neuroblastoma at first presentation and throughout follow-up. These expert opinions aim to improve reproducibility and enhance diagnostic performance in order to advance the current standard of care and assist in the development of future trials.",

keywords = "computed tomography, high-risk neuroblastoma, imaging, magnetic resonance imaging, neuroblastoma response assessment, nuclear medicine, pediatric neuroblastoma diagnosis",

author = "Annemieke Littooij and Catia Olianti and Herve Brisse and \{Di Paolo\}, \{Pier Luigi\} and Maria Garganese and Tepas Kapadia and Jurgen Schaefer and Hugh Wallace and Simon Wan and \{de Keizer\}, Bart and \{Sefic Pasic\}, Irmina and Julian Rogasch",

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AU - Littooij, Annemieke

AU - Olianti, Catia

AU - Brisse, Herve

AU - Di Paolo, Pier Luigi

AU - Garganese, Maria

AU - Kapadia, Tepas

AU - Schaefer, Jurgen

AU - Wallace, Hugh

AU - Wan, Simon

AU - de Keizer, Bart

AU - Sefic Pasic, Irmina

AU - Rogasch, Julian

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AB - Neuroblastoma is the most common extracranial solid tumor in early childhood. Its clinical behavior is highly variable, ranging from spontaneous regression to fatal outcome despite intensive treatment. The International Society of Pediatric Oncology Europe Neuroblastoma Group (SIOPEN) Radiology and Nuclear Medicine Specialty Committees developed consensus-based imaging recommendations for high-risk neuroblastoma at first presentation and throughout follow-up. These expert opinions aim to improve reproducibility and enhance diagnostic performance in order to advance the current standard of care and assist in the development of future trials.

KW - computed tomography

KW - high-risk neuroblastoma

KW - imaging

KW - magnetic resonance imaging

KW - neuroblastoma response assessment

KW - nuclear medicine

KW - pediatric neuroblastoma diagnosis

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DO - 10.1002/1545-5017.70180

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ER -

Imaging of High-Risk Neuroblastoma: Recommendations From SIOPEN Radiology and Nuclear Medicine Specialty Committees

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Keywords

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