Imaging markers of intracranial aneurysm development: A systematic review

Angelina K. Kancheva*, Birgitta K. Velthuis, Ynte M. Ruigrok

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Downloads (Pure)


BACKGROUND: Imaging markers of intracranial aneurysm (IA) development are not well established.

PURPOSE: To provide an overview of imaging markers of IA development.

METHODS: A systematic search of PubMed and Embase up to December 1st 2020 using predefined criteria. Thirty-six studies met our inclusion criteria. We performed a quantitative summary of the included studies.

RESULTS: We found converging evidence for A1 segment asymmetry as an anatomical marker of anterior communicating artery (Acom) aneurysm development, and moderate evidence for several other markers. No hemodynamic markers yielded converging or moderate evidence. There was large heterogeneity across studies, especially in the definitions of imaging markers and study outcomes used. Due to the poor methodological quality of many studies and unavailability of effect sizes or crude data to calculate effect sizes, a formal meta-analysis was not possible.

CONCLUSIONS: We only identified A1 segment asymmetry as an imaging marker of Acom aneurysm development with converging evidence. A meta-analysis was not possible due to the heterogeneity of marker definitions and outcomes used, and poor methodological quality of many studies. Future studies should use robust study designs and uniformly defined imaging markers and outcome measures.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalJournal of neuroradiology
Issue number2
Early online date8 Oct 2021
Publication statusPublished - Mar 2022


  • Imaging marker
  • Intracranial aneurysm
  • Neuroimaging
  • Subarachnoid hemorrhage


Dive into the research topics of 'Imaging markers of intracranial aneurysm development: A systematic review'. Together they form a unique fingerprint.

Cite this