TY - JOUR
T1 - Imaging markers of intracranial aneurysm development
T2 - A systematic review
AU - Kancheva, Angelina K.
AU - Velthuis, Birgitta K.
AU - Ruigrok, Ynte M.
N1 - Funding Information:
We acknowledge the support from the Netherlands Cardiovascular Research Initiative : An initiative with support of the Dutch Heart Foundation , CVON2015-08 ERASE. This project has received funding from the European Research Council ( ERC ) under the European Union's Horizon 2020 research and innovation program (grant agreement No. 852173 ).
Publisher Copyright:
© 2021 The Author(s)
PY - 2022/3
Y1 - 2022/3
N2 - BACKGROUND: Imaging markers of intracranial aneurysm (IA) development are not well established.PURPOSE: To provide an overview of imaging markers of IA development.METHODS: A systematic search of PubMed and Embase up to December 1st 2020 using predefined criteria. Thirty-six studies met our inclusion criteria. We performed a quantitative summary of the included studies.RESULTS: We found converging evidence for A1 segment asymmetry as an anatomical marker of anterior communicating artery (Acom) aneurysm development, and moderate evidence for several other markers. No hemodynamic markers yielded converging or moderate evidence. There was large heterogeneity across studies, especially in the definitions of imaging markers and study outcomes used. Due to the poor methodological quality of many studies and unavailability of effect sizes or crude data to calculate effect sizes, a formal meta-analysis was not possible.CONCLUSIONS: We only identified A1 segment asymmetry as an imaging marker of Acom aneurysm development with converging evidence. A meta-analysis was not possible due to the heterogeneity of marker definitions and outcomes used, and poor methodological quality of many studies. Future studies should use robust study designs and uniformly defined imaging markers and outcome measures.
AB - BACKGROUND: Imaging markers of intracranial aneurysm (IA) development are not well established.PURPOSE: To provide an overview of imaging markers of IA development.METHODS: A systematic search of PubMed and Embase up to December 1st 2020 using predefined criteria. Thirty-six studies met our inclusion criteria. We performed a quantitative summary of the included studies.RESULTS: We found converging evidence for A1 segment asymmetry as an anatomical marker of anterior communicating artery (Acom) aneurysm development, and moderate evidence for several other markers. No hemodynamic markers yielded converging or moderate evidence. There was large heterogeneity across studies, especially in the definitions of imaging markers and study outcomes used. Due to the poor methodological quality of many studies and unavailability of effect sizes or crude data to calculate effect sizes, a formal meta-analysis was not possible.CONCLUSIONS: We only identified A1 segment asymmetry as an imaging marker of Acom aneurysm development with converging evidence. A meta-analysis was not possible due to the heterogeneity of marker definitions and outcomes used, and poor methodological quality of many studies. Future studies should use robust study designs and uniformly defined imaging markers and outcome measures.
KW - Imaging marker
KW - Intracranial aneurysm
KW - Neuroimaging
KW - Subarachnoid hemorrhage
UR - http://www.scopus.com/inward/record.url?scp=85118770847&partnerID=8YFLogxK
U2 - 10.1016/j.neurad.2021.09.001
DO - 10.1016/j.neurad.2021.09.001
M3 - Review article
C2 - 34634299
AN - SCOPUS:85118770847
SN - 0150-9861
VL - 49
SP - 219
EP - 224
JO - Journal of neuroradiology
JF - Journal of neuroradiology
IS - 2
ER -