Imaging hallmarks of cancer in living mice

Translated title of the contribution: Imaging hallmarks of cancer in living mice

S.I. Ellenbroek, J. van Rheenen

Research output: Contribution to journalArticleAcademicpeer-review


To comprehend the complexity of cancer, the biological characteristics acquired during the initiation and progression of tumours were classified as the 'hallmarks of cancer'. Intravital microscopy techniques have been developed to study individual cells that acquire these crucial traits, by visualizing tissues with cellular or subcellular resolution in living animals. In this Review, we highlight the latest intravital microscopy techniques that have been used in living animals (predominantly mice) to unravel fundamental and dynamic aspects of various hallmarks of cancer. In addition, we discuss the application of intravital microscopy techniques to cancer therapy, as well as limitations and future perspectives for these techniques
Translated title of the contributionImaging hallmarks of cancer in living mice
Original languageUndefined/Unknown
Pages (from-to)406-418
Number of pages13
JournalNature Reviews Cancer
Issue number6
Publication statusPublished - 2014


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