TY - JOUR
T1 - Identifying treatment response to antihypertensives in patients with obesity-related hypertension
AU - Schrover, Ilse M
AU - Dorresteijn, Jannick A N
AU - Smits, Jodine E
AU - Danser, A H Jan
AU - Visseren, Frank L J
AU - Spiering, Wilko
N1 - Publisher Copyright:
© 2017 The Author(s).
PY - 2017/10
Y1 - 2017/10
N2 - Background: In patients with obesity-related hypertension (ORH), reaction to antihypertensive medication is likely influenced by patientcharacteristics. Methods: Effects of aliskiren, moxonidine and hydrochlorothiazide on 24-h blood pressure (BP) were compared to placebo. Linear mixed effect models were used to analyze the effect of patient characteristics on BP levels and treatment response. Results: Systolic BP response to aliskiren was higher in patients with a BMI > 30.7 kg/m2 compared to patients with a BMI ≤ 30.7 kg/m2 (-21 mmHg versus -4 mmHg). In patients with a hsCRP > 1.8 mg/L the systolic BP response to aliskiren was higher than in patients with a low hsCRP (-15 mmHg versus -7 mmHg). Hydrochlorothiazide (HCTZ) treatment effect on systolic BP was -13 mmHg when heart rate > 71 beats/min compared to -3 mmHg when heart rate was ≤ 71 beats/min. Conclusion: In patients with ORH, BP response to aliskiren is positively related to BMI and hsCRP. Systolic BP response to HCTZ is positively related to heart rate and negatively to renin levels. Trial registration: NCT01138423. Registered June 4th, 2010.
AB - Background: In patients with obesity-related hypertension (ORH), reaction to antihypertensive medication is likely influenced by patientcharacteristics. Methods: Effects of aliskiren, moxonidine and hydrochlorothiazide on 24-h blood pressure (BP) were compared to placebo. Linear mixed effect models were used to analyze the effect of patient characteristics on BP levels and treatment response. Results: Systolic BP response to aliskiren was higher in patients with a BMI > 30.7 kg/m2 compared to patients with a BMI ≤ 30.7 kg/m2 (-21 mmHg versus -4 mmHg). In patients with a hsCRP > 1.8 mg/L the systolic BP response to aliskiren was higher than in patients with a low hsCRP (-15 mmHg versus -7 mmHg). Hydrochlorothiazide (HCTZ) treatment effect on systolic BP was -13 mmHg when heart rate > 71 beats/min compared to -3 mmHg when heart rate was ≤ 71 beats/min. Conclusion: In patients with ORH, BP response to aliskiren is positively related to BMI and hsCRP. Systolic BP response to HCTZ is positively related to heart rate and negatively to renin levels. Trial registration: NCT01138423. Registered June 4th, 2010.
KW - Hypertension
KW - Interaction
KW - Obesity
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=85070899579&partnerID=8YFLogxK
U2 - 10.1186/s40885-017-0077-x
DO - 10.1186/s40885-017-0077-x
M3 - Article
C2 - 29085669
SN - 2056-5909
VL - 23
JO - Clinical and experimental hypertension. Part A, Theory and practice
JF - Clinical and experimental hypertension. Part A, Theory and practice
IS - 1
M1 - 20
ER -