Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi

Joris Pothof; Gijs Van Haaften; Karen Thijssen; Ravi S. Kamath; Andrew G. Fraser; Julie Ahringer; Ronald H.A. Plasterk; Marcel Tijsterman

doi:10.1101/gad.1060703

Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi

Joris Pothof, Gijs Van Haaften, Karen Thijssen, Ravi S. Kamath, Andrew G. Fraser, Julie Ahringer, Ronald H.A. Plasterk, Marcel Tijsterman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

182 Citations (Scopus)

Abstract

An RNA interference (RNAi)-based genome-wide screen was performed to detect genes that contribute to genome stability in somatic cells of Caenorhabditis elegans. We identified 61 such genes; these also affect spontaneous mutagenesis in the germ line. Their sequence suggests a role in DNA repair and/or replication, in chromatin remodeling, or in cell cycle control; there are also many novel genes that are highly conserved from yeast to human. Because known mutator genes are causally involved in many hereditary and sporadic human cancers, it is likely that some of these new mutators are equally relevant in cancer etiology.

Original language	English
Pages (from-to)	443-448
Number of pages	6
Journal	Genes and Development
Volume	17
Issue number	4
DOIs	https://doi.org/10.1101/gad.1060703
Publication status	Published - 15 Feb 2003

Keywords

C. elegans
Carcinogenesis
DNA repair
Mutator genes
Spontaneous DNA damage

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AU - Fraser, Andrew G.

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AU - Plasterk, Ronald H.A.

AU - Tijsterman, Marcel

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Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi

Abstract

Keywords

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