Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates

Janetta Top; Jan C. Sinnige; Ellen C. Brouwer; Guido Werner; Jukka Corander; Juliëtte A. Severin; Rogier Jansen; E. Bathoorn; Marc J.M. Bonten; John W.A. Rossen; Rob J.L. Willems

doi:10.1128/AAC.01793-17

Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates

Janetta Top^*, Jan C. Sinnige, Ellen C. Brouwer, Guido Werner, Jukka Corander, Juliëtte A. Severin, Rogier Jansen, E. Bathoorn, Marc J.M. Bonten, John W.A. Rossen, Rob J.L. Willems

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.

Original language	English
Article number	e01793-17
Journal	Antimicrobial Agents and Chemotherapy
Volume	62
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01793-17
Publication status	Published - 1 Mar 2018

Keywords

Enterococcus faecium
Genomic island
Vancomycin resistance
VanD type

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10.1128/AAC.01793-17

Antimicrob. Agents Chemother.-2018-Top-Final published version, 1.54 MB

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Top, J., Sinnige, J. C., Brouwer, E. C., Werner, G., Corander, J., Severin, J. A., Jansen, R., Bathoorn, E., Bonten, M. J. M., Rossen, J. W. A., & Willems, R. J. L. (2018). Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates. Antimicrobial Agents and Chemotherapy, 62(3), Article e01793-17. https://doi.org/10.1128/AAC.01793-17

@article{54270883f7144e219f904cec0d8e016c,

title = "Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates",

abstract = "Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.",

keywords = "Enterococcus faecium, Genomic island, Vancomycin resistance, VanD type",

author = "Janetta Top and Sinnige, {Jan C.} and Brouwer, {Ellen C.} and Guido Werner and Jukka Corander and Severin, {Juli{\"e}tte A.} and Rogier Jansen and E. Bathoorn and Bonten, {Marc J.M.} and Rossen, {John W.A.} and Willems, {Rob J.L.}",

year = "2018",

month = mar,

day = "1",

doi = "10.1128/AAC.01793-17",

language = "English",

volume = "62",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "3",

}

Top, J, Sinnige, JC, Brouwer, EC, Werner, G, Corander, J, Severin, JA, Jansen, R, Bathoorn, E, Bonten, MJM, Rossen, JWA & Willems, RJL 2018, 'Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates', Antimicrobial Agents and Chemotherapy, vol. 62, no. 3, e01793-17. https://doi.org/10.1128/AAC.01793-17

Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates. / Top, Janetta; Sinnige, Jan C.; Brouwer, Ellen C. et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 62, No. 3, e01793-17, 01.03.2018.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates

AU - Top, Janetta

AU - Sinnige, Jan C.

AU - Brouwer, Ellen C.

AU - Werner, Guido

AU - Corander, Jukka

AU - Severin, Juliëtte A.

AU - Jansen, Rogier

AU - Bathoorn, E.

AU - Bonten, Marc J.M.

AU - Rossen, John W.A.

AU - Willems, Rob J.L.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.

AB - Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.

KW - Enterococcus faecium

KW - Genomic island

KW - Vancomycin resistance

KW - VanD type

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U2 - 10.1128/AAC.01793-17

DO - 10.1128/AAC.01793-17

M3 - Article

C2 - 29311068

SN - 0066-4804

VL - 62

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

M1 - e01793-17

ER -

Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates

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