Identification of a novel genomic island associated with vand-type vancomycin resistance in six Dutch vancomycin-resistant enterococcus faecium isolates

Janetta Top*, Jan C. Sinnige, Ellen C. Brouwer, Guido Werner, Jukka Corander, Juliëtte A. Severin, Rogier Jansen, E. Bathoorn, Marc J.M. Bonten, John W.A. Rossen, Rob J.L. Willems

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD-containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals.

Original languageEnglish
Article numbere01793-17
JournalAntimicrobial Agents and Chemotherapy
Volume62
Issue number3
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • Enterococcus faecium
  • Genomic island
  • Vancomycin resistance
  • VanD type

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