Identification and typing of the emerging pathogen Candida auris by matrix-assisted laser desorption ionisation time of flight mass spectrometry

Victoria Girard; Sandrine Mailler; Marion Chetry; Céline Vidal; Géraldine Durand; Alex van Belkum; Arnaldo L Colombo; Ferry Hagen; Jacques F Meis; Anuradha Chowdhary

doi:10.1111/myc.12519

Identification and typing of the emerging pathogen Candida auris by matrix-assisted laser desorption ionisation time of flight mass spectrometry

Victoria Girard
, Sandrine Mailler
, Marion Chetry
, Céline Vidal
, Géraldine Durand
, Alex van Belkum
, Arnaldo L Colombo
, Ferry Hagen
, Jacques F Meis
, Anuradha Chowdhary

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Candida auris is an emerging antifungal resistant yeast species causing nosocomial and invasive infections, emphasising the need of improved diagnostics and epidemiological typing methods. We show that MALDI-TOF VITEK-MS followed by amplified length polymorphisms allows for accurate species identification and subsequent epidemiological characterisation of strains encountered during potential outbreaks.

Original language	English
Pages (from-to)	535-8
Number of pages	4
Journal	Mycoses
Volume	59
Issue number	8
DOIs	https://doi.org/10.1111/myc.12519
Publication status	Published - Aug 2016
Externally published	Yes

Keywords

Antifungal Agents/pharmacology
Candida/classification
Candidiasis/diagnosis
Disease Outbreaks
Humans
Microbial Sensitivity Tests
Polymorphism, Genetic
Sequence Analysis, DNA
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods

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10.1111/myc.12519

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title = "Identification and typing of the emerging pathogen Candida auris by matrix-assisted laser desorption ionisation time of flight mass spectrometry",

abstract = "Candida auris is an emerging antifungal resistant yeast species causing nosocomial and invasive infections, emphasising the need of improved diagnostics and epidemiological typing methods. We show that MALDI-TOF VITEK-MS followed by amplified length polymorphisms allows for accurate species identification and subsequent epidemiological characterisation of strains encountered during potential outbreaks.",

keywords = "Antifungal Agents/pharmacology, Candida/classification, Candidiasis/diagnosis, Disease Outbreaks, Humans, Microbial Sensitivity Tests, Polymorphism, Genetic, Sequence Analysis, DNA, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods",

author = "Victoria Girard and Sandrine Mailler and Marion Chetry and C{\'e}line Vidal and G{\'e}raldine Durand and \{van Belkum\}, Alex and Colombo, \{Arnaldo L\} and Ferry Hagen and Meis, \{Jacques F\} and Anuradha Chowdhary",

note = "{\textcopyright} 2016 Blackwell Verlag GmbH.",

year = "2016",

month = aug,

doi = "10.1111/myc.12519",

language = "English",

volume = "59",

pages = "535--8",

journal = "Mycoses",

issn = "0933-7407",

publisher = "Wiley-Blackwell Publishing Ltd",

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T1 - Identification and typing of the emerging pathogen Candida auris by matrix-assisted laser desorption ionisation time of flight mass spectrometry

AU - Girard, Victoria

AU - Mailler, Sandrine

AU - Chetry, Marion

AU - Vidal, Céline

AU - Durand, Géraldine

AU - van Belkum, Alex

AU - Colombo, Arnaldo L

AU - Hagen, Ferry

AU - Meis, Jacques F

AU - Chowdhary, Anuradha

PY - 2016/8

Y1 - 2016/8

N2 - Candida auris is an emerging antifungal resistant yeast species causing nosocomial and invasive infections, emphasising the need of improved diagnostics and epidemiological typing methods. We show that MALDI-TOF VITEK-MS followed by amplified length polymorphisms allows for accurate species identification and subsequent epidemiological characterisation of strains encountered during potential outbreaks.

AB - Candida auris is an emerging antifungal resistant yeast species causing nosocomial and invasive infections, emphasising the need of improved diagnostics and epidemiological typing methods. We show that MALDI-TOF VITEK-MS followed by amplified length polymorphisms allows for accurate species identification and subsequent epidemiological characterisation of strains encountered during potential outbreaks.

KW - Antifungal Agents/pharmacology

KW - Candida/classification

KW - Candidiasis/diagnosis

KW - Disease Outbreaks

KW - Humans

KW - Microbial Sensitivity Tests

KW - Polymorphism, Genetic

KW - Sequence Analysis, DNA

KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods

U2 - 10.1111/myc.12519

DO - 10.1111/myc.12519

M3 - Article

C2 - 27292939

SN - 0933-7407

VL - 59

SP - 535

EP - 538

JO - Mycoses

JF - Mycoses

IS - 8

ER -

Identification and typing of the emerging pathogen Candida auris by matrix-assisted laser desorption ionisation time of flight mass spectrometry

Abstract

Keywords

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